SHC1 information

SHC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1MIL, 1N3H, 1OY2, 1QG1, 1SHC, 1TCE, 2L1C, 4JMH, 4XWX, 5CZI
Identifiers
Aliases	SHC1, SHC, SHCA, SHC adaptor protein 1
External IDs	OMIM: 600560; MGI: 98296; HomoloGene: 7934; GeneCards: SHC1; OMA:SHC1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	154,974,395 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	89,337,334 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; gallbladder; ; smooth muscle tissue; ; Descending thoracic aorta; ; gastric mucosa; ; anterior pituitary; ; left uterine tube; ; cartilage tissue; ; right lobe of thyroid gland; ; canal of the cervix;
	Top expressed in
	lens; ; tail of embryo; ; granulocyte; ; uterus; ; genital tubercle; ; lung; ; yolk sac; ; islet of Langerhans; ; epiblast; ; stomach;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	insulin-like growth factor receptor binding; transmembrane receptor protein tyrosine kinase adaptor activity; insulin receptor binding; neurotrophin TRKA receptor binding; ephrin receptor binding; epidermal growth factor receptor binding; receptor tyrosine kinase binding; protein binding; phospholipid binding; epidermal growth factor binding; phosphotyrosine residue binding;
Cellular component	cytoplasm; cytosol; mitochondrial matrix; mitochondrion; Shc-EGFR complex; plasma membrane;
Biological process	actin cytoskeleton reorganization; insulin receptor signaling pathway; intracellular signal transduction; epidermal growth factor receptor signaling pathway; cellular response to growth factor stimulus; MAPK cascade; Fc-epsilon receptor signaling pathway; heart development; IRE1-mediated unfolded protein response; regulation of cell population proliferation; angiogenesis; regulation of epidermal growth factor-activated receptor activity; regulation of growth; Ras protein signal transduction; viral process; leukocyte migration; signal transduction; ERBB2 signaling pathway; axon guidance; defense response to bacterium; negative regulation of apoptotic process; positive regulation of MAPK cascade; negative regulation of transcription, DNA-templated; positive regulation of transcription, DNA-templated; positive regulation of ERK1 and ERK2 cascade; cell-cell adhesion; interleukin-15-mediated signaling pathway; negative regulation of angiogenesis; cytokine-mediated signaling pathway; interleukin-2-mediated signaling pathway; positive regulation of cell proliferation in bone marrow; regulation of superoxide metabolic process; positive regulation of cell population proliferation; positive regulation of Ras protein signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	6464
	20416
	ENSG00000160691
	ENSMUSG00000042626
	P29353
	P98083
	NM_001130040; NM_001130041; NM_001202859; NM_003029; NM_183001
	NM_001113331; NM_011368
	NP_001123512; NP_001123513; NP_001189788; NP_003020; NP_892113
	NP_001106802; NP_035498
	Wikidata
View/Edit Human	View/Edit Mouse

SHC-transforming protein 1 is a protein that in humans is encoded by the SHC1 gene.^[5] SHC has been found to be important in the regulation of apoptosis and drug resistance in mammalian cells.

SCOP classifies the 3D structure as belonging to the SH2 domain family.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160691 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042626 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pelicci G, Lanfrancone L, Grignani F, McGlade J, Cavallo F, Forni G, Nicoletti I, Grignani F, Pawson T, Pelicci PG (Jul 1992). "A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction". Cell. 70 (1): 93–104. doi:10.1016/0092-8674(92)90536-L. PMID 1623525. S2CID 20390181.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000160691 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042626 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1623525-5] Pelicci G, Lanfrancone L, Grignani F, McGlade J, Cavallo F, Forni G, Nicoletti I, Grignani F, Pawson T, Pelicci PG (Jul 1992). "A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction". Cell. 70 (1): 93–104. doi:10.1016/0092-8674(92)90536-L. PMID 1623525. S2CID 20390181.

SHC1 information

and 23 Related for: SHC1 information

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SH2 domain

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Chromosome 1

Epidermal growth factor receptor

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GRB2

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