GRB2 information

GRB2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AZE, 1BM2, 1BMB, 1CJ1, 1FHS, 1FYR, 1GCQ, 1GFC, 1GFD, 1GHU, 1GRI, 1IO6, 1JYQ, 1JYR, 1JYU, 1QG1, 1TZE, 1X0N, 1ZFP, 2AOA, 2AOB, 2H5K, 2HUW, 2VVK, 2VWF, 2W0Z, 3C7I, 3IMD, 3IMJ, 3IN7, 3IN8, 3KFJ, 3MXC, 3MXY, 3N7Y, 3N84, 3N8M, 3OV1, 3OVE, 3S8L, 3S8N, 3S8O, 2H46, 3WA4, 4P9V, 4P9Z, 5CDW
Identifiers
Aliases	GRB2, ASH, EGFRBP-Grb3-3, MST084, MSTP084, NCKAP2, growth factor receptor bound protein 2
External IDs	OMIM: 108355 MGI: 95805 HomoloGene: 1576 GeneCards: GRB2
Gene location (Human)
Chr.	Chromosome 17 (human)
End	75,405,709 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	115,599,423 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; superficial temporal artery; ; lymph node; ; lower lobe of lung; ; ganglionic eminence; ; spleen; ; thymus; ; prefrontal cortex; ; stromal cell of endometrium;
	Top expressed in
	superior frontal gyrus; ; cerebellar cortex; ; blood; ; lip; ; thymus; ; dorsomedial hypothalamic nucleus; ; piriform cortex; ; yolk sac; ; morula; ; entorhinal cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein domain specific binding; SH3 domain binding; protein kinase binding; identical protein binding; neurotrophin TRKA receptor binding; protein phosphatase binding; protein binding; ephrin receptor binding; insulin receptor substrate binding; epidermal growth factor receptor binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; 1-phosphatidylinositol-3-kinase activity; phosphoprotein binding; enzyme binding; RNA binding; non-membrane spanning protein tyrosine kinase activity; phosphotyrosine residue binding;
Cellular component	extracellular exosome; nucleolus; cytoplasm; nucleoplasm; COP9 signalosome; Golgi apparatus; cytosol; nucleus; cell-cell junction; membrane; Grb2-EGFR complex; endosome; vesicle membrane; plasma membrane; extrinsic component of cytoplasmic side of plasma membrane; protein-containing complex; intracellular anatomical structure;
Biological process	T cell costimulation; Fc-gamma receptor signaling pathway involved in phagocytosis; branching involved in labyrinthine layer morphogenesis; MAPK cascade; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; insulin receptor signaling pathway; receptor internalization; cell-cell signaling; axon guidance; positive regulation of reactive oxygen species metabolic process; cellular response to ionizing radiation; Fc-epsilon receptor signaling pathway; viral process; positive regulation of actin filament polymerization; signal transduction in response to DNA damage; negative regulation of epidermal growth factor receptor signaling pathway; leukocyte migration; regulation of MAPK cascade; anatomical structure formation involved in morphogenesis; human ageing; ERBB2 signaling pathway; phosphatidylinositol phosphate biosynthetic process; phosphatidylinositol-3-phosphate biosynthetic process; protein heterooligomerization; entry of bacterium into host cell; membrane organization; cell migration; cell differentiation; peptidyl-tyrosine autophosphorylation; regulation of cell population proliferation; innate immune response; Ras protein signal transduction; interleukin-15-mediated signaling pathway; positive regulation of protein kinase B signaling; regulation of molecular function; cytokine-mediated signaling pathway; positive regulation of Ras protein signal transduction; neurotrophin TRK receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2885
	14784
	ENSG00000177885
	ENSMUSG00000059923
	P62993
	Q60631
	NM_203506; NM_002086
	NM_008163; NM_001313936; NM_001313937
	NP_002077; NP_987102
	NP_001300865; NP_001300866; NP_032189
	Wikidata
View/Edit Human	View/Edit Mouse

Growth factor receptor-bound protein 2, also known as Grb2, is an adaptor protein involved in signal transduction/cell communication. In humans, the GRB2 protein is encoded by the GRB2 gene.^[5]^[6]

The protein encoded by this gene binds receptors such as the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the sem-5 gene of Caenorhabditis elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000177885 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000059923 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Matuoka K, Shibata M, Yamakawa A, Takenawa T (October 1992). "Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries". Proceedings of the National Academy of Sciences of the United States of America. 89 (19): 9015–9. Bibcode:1992PNAS...89.9015M. doi:10.1073/pnas.89.19.9015. PMC 50055. PMID 1384039.
^ Lowenstein EJ, Daly RJ, Batzer AG, Li W, Margolis B, Lammers R, Ullrich A, Skolnik EY, Bar-Sagi D, Schlessinger J (August 1992). "The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling". Cell. 70 (3): 431–42. doi:10.1016/0092-8674(92)90167-B. PMID 1322798.
^ "Entrez Gene: GRB2 growth factor receptor-bound protein 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000177885 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000059923 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1384039-5] Matuoka K, Shibata M, Yamakawa A, Takenawa T (October 1992). "Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries". Proceedings of the National Academy of Sciences of the United States of America. 89 (19): 9015–9. Bibcode:1992PNAS...89.9015M. doi:10.1073/pnas.89.19.9015. PMC 50055. PMID 1384039.

[pmid1322798-6] Lowenstein EJ, Daly RJ, Batzer AG, Li W, Margolis B, Lammers R, Ullrich A, Skolnik EY, Bar-Sagi D, Schlessinger J (August 1992). "The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling". Cell. 70 (3): 431–42. doi:10.1016/0092-8674(92)90167-B. PMID 1322798.

[7] "Entrez Gene: GRB2 growth factor receptor-bound protein 2".

GRB2 information

and 20 Related for: GRB2 information

GRB2

GAB2

Signal transducing adaptor protein

Grb2 associated binding protein 3

Src homology domain

Second messenger system

Cell signaling

SOS1

CD28

GRAP

Nerve growth factor

HER2

Epidermal growth factor receptor

Huntingtin

Guanine nucleotide exchange factor

GRAP2

Amide ring

SGIP1

Mast cell

Janus kinase 2