Self-stable region of a protein's chain that folds independently from the rest
Pyruvate kinase, a protein with three domains (PDB: 1PKN).
In molecular biology, a protein domain is a region of a protein's polypeptide chain that is self-stabilizing and that folds independently from the rest. Each domain forms a compact folded three-dimensional structure. Many proteins consist of several domains, and a domain may appear in a variety of different proteins. Molecular evolution uses domains as building blocks and these may be recombined in different arrangements to create proteins with different functions. In general, domains vary in length from between about 50 amino acids up to 250 amino acids in length.[1] The shortest domains, such as zinc fingers, are stabilized by metal ions or disulfide bridges. Domains often form functional units, such as the calcium-binding EF hand domain of calmodulin. Because they are independently stable, domains can be "swapped" by genetic engineering between one protein and another to make chimeric proteins.
^Xu D, Nussinov R (1 February 1998). "Favorable domain size in proteins". Folding & Design. 3 (1): 11–7. doi:10.1016/S1359-0278(98)00004-2. PMID 9502316.
biology, a proteindomain is a region of a protein's polypeptide chain that is self-stabilizing and that folds independently from the rest. Each domain forms...
Protein structure is the three-dimensional arrangement of atoms in an amino acid-chain molecule. Proteins are polymers – specifically polypeptides – formed...
This may use either whole proteins or proteindomains, especially in multi-domainproteins. Proteindomains allow protein classification by a combination...
The protein kinase domain is a structurally conserved proteindomain containing the catalytic function of protein kinases. Protein kinases are a group...
The SRC Homology 3 Domain (or SH3 domain) is a small proteindomain of about 60 amino acid residues. Initially, SH3 was described as a conserved sequence...
2) domain is a structurally conserved proteindomain contained within the Src oncoprotein and in many other intracellular signal-transducing proteins. SH2...
protein followed soon thereafter by the Krüppel factor in Drosophila. It often appears as a metal-binding domain in multi-domainproteins. Proteins that...
Protein structure prediction is the inference of the three-dimensional structure of a protein from its amino acid sequence—that is, the prediction of...
Magnetic domain (physics), a region within a magnetic material which has uniform magnetization Proteindomain (biology), a part of a protein that can...
Solenoid proteindomains are a highly modular type of proteindomain. They consist of a chain of nearly identical folds, often simply called tandem repeats...
single polypeptide chain "backbone" with one or more protein secondary structures, the proteindomains. Amino acid side chains and the backbone may interact...
domain is a common structural domain of 80-90 amino-acids found in the signaling proteins of bacteria, yeast, plants, viruses and animals. Proteins containing...
and hydrolysis takes place in the highly conserved P-loop "G domain", a proteindomain common to many GTPases. GTPases function as molecular switches...
(UBA) domains are proteindomains that non-covalently interact with ubiquitin through protein-protein interactions. Ubiquitin is a small protein that is...
In molecular biology, the proteindomain SAICAR synthase is an enzyme which catalyses a reaction to create SAICAR. In enzymology, this enzyme is also known...
The WWE domains occur in two functional classes of proteins, namely those associated with ubiquitination and those associated with poly-ADP ribosylation...
Pleckstrin homology domain (PH domain) or (PHIP) is a proteindomain of approximately 120 amino acids that occurs in a wide range of proteins involved in intracellular...
A protein family is a group of evolutionarily related proteins. In many cases, a protein family has a corresponding gene family, in which each gene encodes...
within many protein structural domains, resulting in an activation of their biological activity. Additionally, the positioning of many proteins are localized...
In molecular biology, the WAC domain is a proteindomain found on the N-terminus of WSTF protein. Its function is still unknown, but putatively thought...
processes could not occur. This proteindomain is thought to be part of a much larger protein complex which includes other proteins such as SeqB. DNA replication...
In molecular biology, YadA is a proteindomain which is short for Yersinia adhesin A. These proteins have strong sequence and structural homology, particularly...
domains refers to two evolutionally-conserved proteindomains found in saposin and related proteins (SAPLIP). Saposins are small lysosomal proteins that...
intracellular heterotrimeric G protein complex by proteindomain dynamics. The Gs alpha subunit of the stimulated G protein complex exchanges GDP for GTP...
A transmembrane domain (TMD) is a membrane-spanning proteindomain. TMDs may consist of one or several alpha-helices or a transmembrane beta barrel. Because...
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