positive regulation of vascular endothelial cell proliferation
positive regulation of endothelial cell apoptotic process
signal transduction
activation of phospholipase C activity
positive regulation of phospholipase C activity
modulation of chemical synaptic transmission
calcium ion transport
inositol trisphosphate biosynthetic process
phosphatidylinositol-mediated signaling
release of sequestered calcium ion into cytosol
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
5335
18803
Ensembl
ENSG00000124181
ENSMUSG00000016933
UniProt
P19174
Q62077
RefSeq (mRNA)
NM_002660 NM_182811
NM_021280
RefSeq (protein)
NP_002651 NP_877963
NP_067255
Location (UCSC)
Chr 20: 41.14 – 41.2 Mb
Chr 2: 160.57 – 160.62 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Phospholipase C, gamma 1, also known as PLCG1 and PLCgamma1, is a protein that in humans involved in cell growth, migration, apoptosis, and proliferation. It is encoded by the PLCG1 gene[5][6] and is part of the PLC superfamily.
^ abcGRCh38: Ensembl release 89: ENSG00000124181 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000016933 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Bristol A, Hall SM, Kriz RW, Stahl ML, Fan YS, Byers MG, Eddy RL, Shows TB, Knopf JL (1988). "Phospholipase C-148: chromosomal location and deletion mapping of functional domains". Cold Spring Harbor Symposia on Quantitative Biology. 53 (2): 915–20. doi:10.1101/sqb.1988.053.01.105. PMID 3254788.
^Burgess WH, Dionne CA, Kaplow J, Mudd R, Friesel R, Zilberstein A, Schlessinger J, Jaye M (September 1990). "Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase". Molecular and Cellular Biology. 10 (9): 4770–7. doi:10.1128/mcb.10.9.4770. PMC 361079. PMID 2167438.
as PLCG1 and PLCgamma1, is a protein that in humans involved in cell growth, migration, apoptosis, and proliferation. It is encoded by the PLCG1 gene...
role in the regulation of immunoreceptor signaling, including PLC-gamma (PLCG1; MIM 172420)-mediated B cell antigen receptor (BCR) signaling and FC-epsilon...
non-small cell lung cancer survival. FLT1 has been shown to interact with PLCG1 and vascular endothelial growth factor B (VEGF-B). VEGF receptors GRCh38:...
stimulation Activation of the gamma isoforms of phospholipase C (PLCγ) (see PLCG1 and PLCG2 illustrates one mechanism by which FGFR1 activates cell stimulating...
TrkA has been shown to interact with: Abl gene, FRS2, Grb2, MATK, NGFB, PLCG1, RICS, SQSTM1, SH2B1, SH2B2, and SHC1. Small molecules such as amitriptyline...
proteins that trigger downstream signaling cascades. Signaling through PLCG1, PI3K and RAAS, downstream of activated NTRK3, regulates cell survival,...
as a 40% reduction in brain mass. IRS2 has been shown to interact with: PLCG1, SOCS1, and PIK3R1, GRCh38: Ensembl release 89: ENSG00000185950 – Ensembl...
phospholipase C (PLC) through different receptors like the T-cell receptor (TCR) (PLCG1[citation needed]) or B-cell receptor (BCR) (PLCG2[citation needed]). This...
through interfering with the phosphorylation of Phospholipase C Gamma 1 (PLCG1) and Linker for Activation of T Cells (LAT). This PTP was also found to...
translation elongation factor 1 alpha 1 has been shown to interact with: PLCG1, actin, muscarinic acetylcholine receptor, α2 subunit of GlyR, and SAMHD1...
heterotrimeric G protein-coupled receptors, while the closely related C-gamma-1 (PLCG1; MIM 172420) and C-gamma-2 enzymes are controlled by receptor tyrosine kinases...