ZAP70, SRK, STCD, STD, TZK, ZAP-70, zeta chain of T cell receptor associated protein kinase 70kDa, zeta chain of T cell receptor associated protein kinase 70, zeta chain of T-cell receptor associated protein kinase 70, IMD48, ADMIO2
non-membrane spanning protein tyrosine kinase activity
kinase activity
protein binding
protein tyrosine kinase activity
signaling receptor binding
ATP binding
phosphotyrosine residue binding
Cellular component
cytoplasm
cytosol
membrane
cell-cell junction
extrinsic component of cytoplasmic side of plasma membrane
plasma membrane
T cell receptor complex
immunological synapse
membrane raft
Biological process
positive regulation of T cell differentiation
T cell migration
positive regulation of calcium-mediated signaling
intracellular signal transduction
adaptive immune response
phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
immune system process
T cell aggregation
beta selection
negative thymic T cell selection
protein phosphorylation
B cell activation
T cell differentiation
immune response
positive thymic T cell selection
peptidyl-tyrosine autophosphorylation
protein autophosphorylation
peptidyl-tyrosine phosphorylation
innate immune response
T cell receptor signaling pathway
thymic T cell selection
positive regulation of alpha-beta T cell differentiation
T cell activation
regulation of cell population proliferation
positive regulation of alpha-beta T cell proliferation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
7535
22637
Ensembl
ENSG00000115085
ENSMUSG00000026117
UniProt
P43403
P43404
RefSeq (mRNA)
NM_001079 NM_207519 NM_001378594
NM_009539 NM_001289612 NM_001289765 NM_001289766
RefSeq (protein)
NP_001070 NP_997402 NP_001365523
NP_001276541 NP_001276694 NP_001276695 NP_033565
Location (UCSC)
Chr 2: 97.71 – 97.74 Mb
Chr 1: 36.8 – 36.82 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
ZAP-70 (Zeta-chain-associated protein kinase 70) is a protein normally expressed near the surface membrane of lymphocytes (T cells, natural killer cells, and a subset of B cells).[5] It is most prominently known to be recruited upon antigen binding to the T cell receptor (TCR), and it plays a critical role in T cell signaling.
ZAP-70 was initially discovered in TCR-stimulated Jurkat cells, an immortal line of human T lymphocytes, in 1991.[6] Its molecular weight is 70 kDa, and it is a member of the protein-tyrosine kinase family and is a close homolog of SYK. SYK and ZAP70 share a common evolutionary origin and split from a common ancestor in the jawed vertebrates. [7]
The importance of ZAP-70 in T cell activation was determined when comparing ZAP-70 expression in patients with SCID (severe combined immunodeficiency).[6] ZAP-70 deficient individuals were found to have no functioning T cells in their peripheral blood, suggesting that ZAP-70 is a critical component of T cell activation and development.[6]
ZAP-70 expression in B cells is correlated with the development of chronic lymphocytic leukemia (CLL).
^ abcGRCh38: Ensembl release 89: ENSG00000115085 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000026117 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Chen J, Moore A, Ringshausen I (2020). "ZAP-70 Shapes the Immune Microenvironment in B Cell Malignancies". Frontiers in Oncology. 10: 595832. doi:10.3389/fonc.2020.595832. PMC 7653097. PMID 33194762.
^ abcWang H, Kadlecek TA, Au-Yeung BB, Goodfellow HE, Hsu LY, Freedman TS, Weiss A (May 2010). "ZAP-70: an essential kinase in T-cell signaling". Cold Spring Harbor Perspectives in Biology. 2 (5): a002279. doi:10.1101/cshperspect.a002279. PMC 2857167. PMID 20452964.
the protein-tyrosine kinase family and is a close homolog of SYK. SYK and ZAP70 share a common evolutionary origin and split from a common ancestor in the...
ZAP70 deficiency, or ZAP70 deficient SCID, is a rare autosomal recessive form of severe combined immunodeficiency (SCID) resulting in a lack of CD8+ T...
TCR and to recruit and activate the ζ-chain- associated protein Zap70 activated Zap70 in turn phosphorylates the membrane adaptor Lat, which subsequently...
activate SH2 domain-containing protein tyrosine kinases (PTK), such as ZAP70, to further mediate downstream signalling through tyrosine phosphorylation...
for the SH2 domain of the SYK family kinase ZAP70, which is there phosphorylated too. The Phosphorylated ZAP70 then propagate a signal from a TCR, phosphorylating...
with hypereosinophilia. The list of such disorders includes ZAP70 deficiency (defective ZAP70 gene), CD3gamma chain deficiency (defective CD3G gene), MCHII...
ISSN 1860-7179. Zhao, Hongtao; Caflisch, Amedeo (2013-10-15). "Discovery of ZAP70 inhibitors by high-throughput docking into a conformation of its kinase...
PLC-gamma-2 Defective BCR signaling PI3K Impaired B and T cell homeostasis ZAP70 Impaired T cell function TLR7 and TLR9 Defects in B cells activation in...
(2017-07-07). "Differential Requirements for Src-Family Kinases in SYK or ZAP70-Mediated SLP-76 Phosphorylation in Lymphocytes". Frontiers in Immunology...
ζ-chain of the T-cell receptor (TCR) to CBL, WASP, p38, LCK, VAV1, and ZAP70. This data suggests that DLG1 plays a role in linking TCR signaling machinery...
DAP12 bears ITAM motif and activates protein tyrosine kinases Syk and Zap70 signalling. NKG2D ligands are induced-self proteins which are completely...
responsiveness to the antigen pigeon cytochrome c peptide, as determined by ZAP70 phosphorylation, proliferation, and interleukin 2 production. Thus Stefanova...
Global Information
