positive regulation of erythrocyte differentiation
negative regulation of osteoclast differentiation
negative regulation of granulocyte differentiation
immune system process
positive regulation of B cell differentiation
negative regulation of B cell activation
inositol phosphate metabolic process
negative regulation of neutrophil differentiation
negative regulation of immune response
phosphatidylinositol dephosphorylation
positive regulation of lymphocyte differentiation
immunoglobulin mediated immune response
positive regulation of apoptotic process
phosphate-containing compound metabolic process
phosphatidylinositol biosynthetic process
negative regulation of signal transduction
negative regulation of B cell proliferation
T cell receptor signaling pathway
leukocyte migration
signal transduction
negative regulation of bone resorption
negative regulation of cell population proliferation
apoptotic process
cytokine-mediated signaling pathway
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
3635
16331
Ensembl
ENSG00000168918 ENSG00000281614
ENSMUSG00000026288
UniProt
Q92835
Q9ES52
RefSeq (mRNA)
NM_001017915 NM_005541
NM_001110192 NM_001110193 NM_010566
RefSeq (protein)
NP_001017915 NP_005532
NP_001103662 NP_001103663 NP_034696
Location (UCSC)
Chr 2: 233.06 – 233.21 Mb
Chr 1: 87.55 – 87.65 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Src homology 2 (SH2) domain containing inositol polyphosphate 5-phosphatase 1(SHIP1) is an enzyme with phosphatase activity. SHIP1 is structured by multiple domain and is encoded by the INPP5D gene in humans.[5][6][7] SHIP1 is expressed predominantly by hematopoietic cells[8] but also, for example, by osteoblasts[9] and endothelial cells.[10] This phosphatase is important for the regulation of cellular activation. Not only catalytic but also adaptor activities of this protein are involved in this process. Its movement from the cytosol to the cytoplasmic membrane, where predominantly performs its function, is mediated by tyrosine phosphorylation of the intracellular chains of cell surface receptors that SHIP1 binds. Insufficient regulation of SHIP1 leads to different pathologies.[11]
^ abcGRCm38: Ensembl release 89: ENSMUSG00000026288 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Damen JE, Liu L, Rosten P, Humphries RK, Jefferson AB, Majerus PW, Krystal G (February 1996). "The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase". Proceedings of the National Academy of Sciences of the United States of America. 93 (4): 1689–93. Bibcode:1996PNAS...93.1689D. doi:10.1073/pnas.93.4.1689. PMC 40003. PMID 8643691.
^Ware MD, Rosten P, Damen JE, Liu L, Humphries RK, Krystal G (October 1996). "Cloning and characterization of human SHIP, the 145-kD inositol 5-phosphatase that associates with SHC after cytokine stimulation". Blood. 88 (8): 2833–40. doi:10.1182/blood.V88.8.2833.bloodjournal8882833. PMID 8874179.
^Geier SJ, Algate PA, Carlberg K, Flowers D, Friedman C, Trask B, Rohrschneider LR (March 1997). "The human SHIP gene is differentially expressed in cell lineages of the bone marrow and blood". Blood. 89 (6): 1876–85. doi:10.1182/blood.V89.6.1876. PMID 9058707.
^Hazen AL, Smith MJ, Desponts C, Winter O, Moser K, Kerr WG (March 2009). "SHIP is required for a functional hematopoietic stem cell niche". Blood. 113 (13): 2924–33. doi:10.1182/blood-2008-02-138008. PMC 2662639. PMID 19074735.
^Zippo A, De Robertis A, Bardelli M, Galvagni F, Oliviero S (June 2004). "Identification of Flk-1 target genes in vasculogenesis: Pim-1 is required for endothelial and mural cell differentiation in vitro". Blood. 103 (12): 4536–44. doi:10.1182/blood-2003-11-3827. PMID 14982870. S2CID 41934928.
^Kerr WG (January 2011). "Inhibitor and activator: dual functions for SHIP in immunity and cancer". Annals of the New York Academy of Sciences. 1217 (1): 1–17. Bibcode:2011NYASA1217....1K. doi:10.1111/j.1749-6632.2010.05869.x. PMC 4515353. PMID 21155837.
activity. SHIP1 is structured by multiple domain and is encoded by the INPP5D gene in humans. SHIP1 is expressed predominantly by hematopoietic cells...
inhibition. CD22 has been shown to interact with Grb2, PTPN6, LYN, SHC1 and INPP5D. GRCm38: Ensembl release 89: ENSMUSG00000030577 – Ensembl, May 2017 "Human...
been found for this gene. LILRB4 has been shown to interact with PTPN6 and INPP5D (SHIP-1). Cluster of differentiation Immunoglobulin superfamily ENSG00000186818...
mitogenic signaling. DOK1 has been shown to interact with: ABL1 and CD117, INPP5D, LYN, RASA1, RET, SH2D1A, SHC1, and TEC. GRCh38: Ensembl release 89: ENSG00000115325...
binds p120 (RasGAP) from CML cells. DOK2 has been shown to interact with INPP5D and TEK tyrosine kinase. GRCh38: Ensembl release 89: ENSG00000147443 – Ensembl...
Global Information
