Rottlerin information

Rottlerin
Clinical data
Other names	Mallotoxin
Identifiers
	IUPAC name (E)-1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethylchromen-8-yl]-3-phenylprop-2-en-1-one;
CAS Number	82-08-6;
PubChem CID	5281847;
IUPHAR/BPS	2611;
ChemSpider	4445144;
UNII	E29LP3ZMUH;
KEGG	C10721;
ChEBI	CHEBI:8899;
ChEMBL	ChEMBL34241;
CompTox Dashboard (EPA)	DTXSID30231502 ;
ECHA InfoCard	100.001.270
Chemical and physical data
Formula	C30H28O8
Molar mass	516.546 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(c1c(O)c(c(O)c(c1O)C)Cc3c(O)c(C(=O)\C=C\c2ccccc2)c4OC(/C=C\c4c3O)(C)C)C;
	InChI InChI=1S/C30H28O8/c1-15-24(33)19(27(36)22(16(2)31)25(15)34)14-20-26(35)18-12-13-30(3,4)38-29(18)23(28(20)37)21(32)11-10-17-8-6-5-7-9-17/h5-13,33-37H,14H2,1-4H3/b11-10+; Key:DEZFNHCVIZBHBI-ZHACJKMWSA-N;

Rottlerin (mallotoxin) is a polyphenol natural product isolated from the Asian tree Mallotus philippensis. Rottlerin displays a complex spectrum of pharmacology.^[1]

^ Soltoff SP (September 2007). "Rottlerin: an inappropriate and ineffective inhibitor of PKCdelta". Trends in Pharmacological Sciences. 28 (9): 453–458. doi:10.1016/j.tips.2007.07.003. PMID 17692392.

[Soltoff_2007-1] Soltoff SP (September 2007). "Rottlerin: an inappropriate and ineffective inhibitor of PKCdelta". Trends in Pharmacological Sciences. 28 (9): 453–458. doi:10.1016/j.tips.2007.07.003. PMID 17692392.

Rottlerin information

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Rottlerin

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