Rivastigmine (sold under the trade name Exelon among others) is a cholinesterase inhibitor used for the treatment of mild to moderate Alzheimer's disease.[4] The drug can be administered orally or via a transdermal patch; the latter form reduces the prevalence of side effects,[5] which typically include nausea and vomiting.[6]
The drug is eliminated through the urine, and appears to have relatively few drug-drug interactions.[6]
It was patented in 1985 and came into medical use in 1997.[7]
^"Prescription medicines: registration of new generic medicines and biosimilar medicines, 2017". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 30 March 2024.
^Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
^"Product monograph brand safety updates". Health Canada. 7 July 2016. Retrieved 1 April 2024.
^Khoury R, Rajamanickam J, Grossberg GT (March 2018). "An update on the safety of current therapies for Alzheimer's disease: focus on rivastigmine". Therapeutic Advances in Drug Safety. 9 (3). SAGE Publications: 171–178. doi:10.1177/2042098617750555. PMC 5810854. PMID 29492246.
^Cite error: The named reference Winblad was invoked but never defined (see the help page).
^ abCite error: The named reference Inglis was invoked but never defined (see the help page).
^Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 540. ISBN 9783527607495.
Rivastigmine (sold under the trade name Exelon among others) is a cholinesterase inhibitor used for the treatment of mild to moderate Alzheimer's disease...
only three of these are available commercially. The three available are rivastigmine, donepezil, and galantamine, while tacrine is not. They are generally...
the central nervous system to alleviate neurological symptoms, such as rivastigmine in Alzheimer's disease, all cholinesterase inhibitors require doses to...
disturbances such as apathy. The effects of donepezil, galantamine and rivastigmine have all been assessed but, overall, the findings have been inconsistent...
auditory hallucinations as a side effect. She was subsequently prescribed rivastigmine instead which reduced the auditory hallucinations and reduced her visual...
the United States by the FDA to treat Alzheimer's include donepezil, rivastigmine, and galantamine. These drugs work to increase the levels of acetylcholine...
blepharospasm, but this can aggravate dysphagia. Two studies have suggested that rivastigmine may help with cognitive aspects, but the authors of both studies have...
transdermal patch, which was launched in the United Kingdom in early 2014. Rivastigmine, an Alzheimer's treatment medication, was released in patch form in 2007...
ability to treat MCI or prevent progression to full Alzheimer's disease. Rivastigmine failed to stop or slow progression to Alzheimer's disease or to improve...
inhibitors, three of which are currently in use: donepezil, galantamine, and rivastigmine. Recently, it has begun to be used in the treatment of orthostatic hypotension...
and reduce the burden on caregivers. Medicines such as donepezil and rivastigmine can temporarily improve cognition and overall functioning, and melatonin...
treat myasthenia gravis, and to treat symptoms of Alzheimer's disease (rivastigmine, which increases cholinergic activity in the brain). Organic mercurial...
who develop dementia there is no evidence for memantine, donepezil, rivastigmine, or galantamine. Between 5-15% of children with Down syndrome in Sweden...
Douglas S, Swann A, Thomas A, et al. (April 2005). "Quetiapine and rivastigmine and cognitive decline in Alzheimer's disease: randomised double blind...
minority of people side effects include a slow heart rate and fainting. Rivastigmine is recommended for treating symptoms in Parkinson's disease dementia...
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