Substance that mimics stimulation of cholinergic receptors
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A parasympathomimetic drug, sometimes called a cholinomimetic drug[1] or cholinergic receptor stimulating agent,[2] is a substance that stimulates the parasympathetic nervous system (PSNS).[3][2] These chemicals are also called cholinergic drugs because acetylcholine (ACh) is the neurotransmitter used by the PSNS.[1][4] Chemicals in this family can act either directly by stimulating the nicotinic or muscarinic receptors (thus mimicking acetylcholine), or indirectly by inhibiting cholinesterase, promoting acetylcholine release, or other mechanisms.[5] Common uses of parasympathomimetics include glaucoma, Sjögren syndrome and underactive bladder.[6]
Some chemical weapons such as sarin or VX, non-lethal riot control agents such as tear gas, and insecticides such as diazinon fall into this category.
^ abDowd, Frank (2017). Pharmacology and therapeutics for dentistry: Chapter 6 - Cholinergic Agonists and Muscarinic Receptor Antagonists. St. Louis, Missouri: Elsevier. pp. 82–97. ISBN 978-0-323-39307-2. OCLC 958121223.
^ abForrester, John V.; Dick, Andrew D.; McMenamin, Paul G.; Roberts, Fiona; Pearlman, Eric (2016). "General and ocular pharmacology". The Eye. Elsevier. pp. 338–369.e1. doi:10.1016/b978-0-7020-5554-6.00006-x. ISBN 978-0-7020-5554-6. Parasympathomimetics are a group of drugs that act either by directly stimulating the muscarinic receptor, for example pilocarpine, or by inhibiting the enzyme acetylcholinesterase, which hydrolyses the acetylcholine in the synapse.
^"Dorlands Medical Dictionary:parasympathomimetic". Archived from the original on 2009-07-26.
^Parasympathomimetics
^Brenner, G. M. (2000). Pharmacology. Philadelphia, PA: W.B. Saunders Company. ISBN 0-7216-7757-6
^Moro, Christian; Phelps, Charlotte; Veer, Vineesha; Clark, Justin; Glasziou, Paul; Tikkinen, Kari A. O.; Scott, Anna M. (2021-11-24). "The effectiveness of parasympathomimetics for treating underactive bladder: A systematic review and meta-analysis". Neurourology and Urodynamics. 41 (1): 127–139. doi:10.1002/nau.24839. ISSN 1520-6777. PMID 34816481. S2CID 244530010.
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A parasympathomimeticdrug, sometimes called a cholinomimetic drug or cholinergic receptor stimulating agent, is a substance that stimulates the parasympathetic...
receptor types ("direct-acting"). Such mimics are called parasympathomimeticdrugs or cholinomimetic drugs. A receptor is cholinergic if it uses acetylcholine...
Demecarium bromide, trade name Humorsol, is a carbamate parasympathomimeticdrug that acts as an acetylcholinesterase inhibitor, and is used as a glaucoma...
airways and reduce mucous production in patients with asthma. Parasympathomimeticdrug "Dorlands Medical Dictionary:parasympatholytic".[permanent dead...
muscle cramps, and fasciculations. ChEIs are indirect-acting parasympathomimeticdrugs. ChEls are widely used as chemical weapons. Since November 2019...
in Gulf War syndrome. With pyridostigmine classified as a type of parasympathomimetic, it can be used to treat underactive bladder. Pyridostigmine sometimes...
hydrolysis when subjected to moisture. Diisopropyl fluorophosphate is a parasympathomimeticdrug irreversible anti-cholinesterase and has been used in ophthalmology...
Bethanechol is a parasympathomimetic choline carbamate that selectively stimulates muscarinic receptors without any effect on nicotinic receptors. Unlike...
gastroduodenal ulcers, and incontinence.[citation needed] The parasympathomimetic action of this drug will exacerbate the symptoms of these disorders.[citation...
demineralisation. The following are used in dentistry to treat xerostomia: Parasympathomimeticdrugs act on parasympathetic muscarinic receptors to induce an increased...
PMID 35593746. Davies, Andrew N; Thompson, Jo (2015-10-05). "Parasympathomimeticdrugs for the treatment of salivary gland dysfunction due to radiotherapy"...
medicine, pharmaceutical drug, medicinal drug or simply drug) is a drug used to diagnose, cure, treat, or prevent disease. Drug therapy (pharmacotherapy)...
is a natural choline compound found in the brain. It is also a parasympathomimetic acetylcholine precursor which has been investigated for its potential...
directly as a serotonin 5-HT4 receptor agonist and indirectly as a parasympathomimetic. Stimulation of the serotonin receptors increases acetylcholine release...
Pilocarpine — a similar parasympathomimetic medication for dry mouth (xerostomia) Bethanechol — a similar muscarinic parasympathomimetic with longer-lasting...
amination of furfural with ammonia. The pharmaceutical drug furtrethonium, a parasympathomimetic cholinergic, is a trimethyl ammonium derivative of furfurylamine...
éséré, the West African name for the Calabar bean) is a highly toxic parasympathomimetic alkaloid, specifically, a reversible cholinesterase inhibitor. It...
progression of visual field loss. Fotil is a combination drug consisting of: Pilocarpine, a parasympathomimetic Timolol, a beta-adrenergic receptor antagonist Basic...
(NaSSA) Some MAO inhibitors Pilocarpine eye drops and all other parasympathomimetics In some rare cases, when exposed to mustard gas Organophosphates...
anticholinergic Pyridostigmine – an acetylcholinesterase inhibitor and parasympathomimetic Serotonin – a serotonin receptor agonist Sotalol – a beta blocker...
Distigmine (as distigmine bromide) is a parasympathomimetic. Distigmine is similar to pyridostigmine and neostigmine but has a longer duration of action...
refer to: Aceclidine, a parasympathomimetic miotic agent used in the treatment of narrow angle glaucoma Piperidione, a sedative drug This set index page lists...
acetylcholinesterase inhibitor and indirect cholinergic agonist (parasympathomimetic). It was the first centrally acting cholinesterase inhibitor approved...
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