negative regulation of cell population proliferation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
590
12038
Ensembl
ENSG00000114200
ENSMUSG00000027792
UniProt
P06276
Q03311
RefSeq (mRNA)
NM_000055
NM_009738
RefSeq (protein)
NP_000046
NP_033868
Location (UCSC)
Chr 3: 165.77 – 165.84 Mb
Chr 3: 73.54 – 73.62 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Butyrylcholinesterase (HGNC symbol BCHE; EC 3.1.1.8), also known as BChE, BuChE, BuChase, pseudocholinesterase, or plasma (cholin)esterase,[5] is a nonspecific cholinesterase enzyme that hydrolyses many different choline-based esters. In humans, it is made in the liver, found mainly in blood plasma, and encoded by the BCHE gene.[6]
It is very similar to the neuronal acetylcholinesterase, which is also known as RBC or erythrocyte cholinesterase.[5] The term "serum cholinesterase" is generally used in reference to a clinical test that reflects levels of both of these enzymes in the blood.[5] Assay of butyrylcholinesterase activity in plasma can be used as a liver function test as both hypercholinesterasemia and hypocholinesterasemia indicate pathological processes. The half-life of BCHE is approximately 10 to 14 days.[7]
Butyrylcholine is a synthetic compound that does not occur in the body naturally. It is used as a tool to distinguish between acetylcholinesterase and butyrylcholinesterase.
^ abcGRCh38: Ensembl release 89: ENSG00000114200 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000027792 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abcJasmin L (2013-05-28). "Cholinesterase - blood". University of Maryland Medical Center. Archived from the original on 2012-10-30. Retrieved 2011-09-07.
^Allderdice PW, Gardner HA, Galutira D, Lockridge O, LaDu BN, McAlpine PJ (October 1991). "The cloned butyrylcholinesterase (BCHE) gene maps to a single chromosome site, 3q26". Genomics. 11 (2): 452–454. doi:10.1016/0888-7543(91)90154-7. hdl:2027.42/29109. PMID 1769657.
^Whittaker M (February 1980). "Plasma cholinesterase variants and the anaesthetist". Anaesthesia. 35 (2): 174–197. doi:10.1111/j.1365-2044.1980.tb03800.x. PMID 6992635. S2CID 32806785.
and 30 Related for: Butyrylcholinesterase information
Butyrylcholinesterase (HGNC symbol BCHE; EC 3.1.1.8), also known as BChE, BuChE, BuChase, pseudocholinesterase, or plasma (cholin)esterase, is a nonspecific...
blood plasma enzyme abnormality in which the body's production of butyrylcholinesterase (BCHE; pseudocholinesterase aka PCE) is impaired. People who have...
into two subgroups, acetylcholinesterase inhibitors (AChEIs) and butyrylcholinesterase inhibitors (BChEIs). ChEIs may be used as drugs for Alzheimer's...
chemical synapses and red blood cell membranes. The other type is butyrylcholinesterase (also called choline esterase II or plasma cholinesterase); it is...
a potent regulator of plant growth and ripeness. It is also a butyrylcholinesterase inhibitor. Ethephon often used on wheat, coffee, tobacco, cotton...
intravenously, it is capable of inhibiting the plasma cholinesterase (butyrylcholinesterase) enzyme. The dibucaine number is used to differentiate individuals...
distinguish between the cholinesterases; acetylcholinesterase and butyrylcholinesterase preferentially lyse acetylcholine and butyrylcholine, respectively...
patients. These effects might reflect the additional inhibition of butyrylcholinesterase, which is implicated in symptom progression and might provide added...
of acetylcholinesterase and the closely related target enzyme, butyrylcholinesterase. The X-ray structures clarify important aspects of the reaction...
to anesthetic agents, are rapidly metabolized in the plasma by butyrylcholinesterase to para-aminobenzoic acid derivatives, then excreted in the urine...
Pseudocholinesterase may refer to: Butyrylcholinesterase, an enzyme Aryl-acylamidase, an enzyme This article includes a list of related items that share...
Chelidonine is an isolate of Papaveraceae with acetylcholinesterase and butyrylcholinesterase inhibitory activity. Chelidonine is the major alkaloid component...
plasma butyrylcholinesterase and the duration of effect is usually in the range of a few minutes. When plasma levels of butyrylcholinesterase are greatly...
cholinesterase. It is an inhibitor of both acetylcholinesterase and butyrylcholinesterase. As a chemical weapon, it is classified as a weapon of mass destruction...
higher vertebrates also encode a closely related paralog BCHE (butyrylcholinesterase) with 50% amino acid identity to ACHE. Diversity in the transcribed...
February 2012). "Reaction Pathway and Free Energy Profiles for Butyrylcholinesterase-Catalyzed Hydrolysis of Acetylthiocholine". Biochemistry. 51 (6):...
doi:10.1016/B978-0-7020-3145-8.00005-3. ISBN 978-0-7020-3145-8. "Butyrylcholinesterase". OMIM. Retrieved 4 September 2015. Einhorn A, Fiedler K, Ladisch...
non-depolarizing neuromuscular blockers, acetylcholinesterase inhibitors, and butyrylcholinesterase inhibitors. Clinically, neuromuscular drugs are used in anesthesia...
Macakova K., Kulhankova A., Host'alkova A.,"Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Chelidonium majus (Papaveraceae)." Natural...
moderate selectivity (15×) for the plasma cholinesterase enzyme butyrylcholinesterase, and relatively weaker inhibition of the better-known acetylcholinesterase...
3-benzodioxaphosphoran-2-one (CBDP). This metabolite can bind to butyrylcholinesterase (BuChE) and/or acetylcholinesterase (AChE). Binding to BuChE results...
[unreliable medical source?] Benzonatate is hydrolyzed by plasma butyrylcholinesterase (BChE) to the metabolite 4-(butylamino)benzoic acid (BABA) as well...
in plasma by butyrylcholinesterase (hBChE). CES2 has a 12.5-fold higher affinity for irinotecan than CES1. While, butyrylcholinesterase has a 6-fold higher...
mammals including humans. It inhibits acetylcholinesterase and butyrylcholinesterase. Phorate is most commonly applied in granular form. It is non-biocumulative...
typically based on the symptoms and can be confirmed by measuring butyrylcholinesterase activity in the blood. Carbamate poisoning can present similarly...
P (May 2013). "Caffeine inhibits acetylcholinesterase, but not butyrylcholinesterase". International Journal of Molecular Sciences. 14 (5): 9873–9882...
died of SIDS exhibited significantly lower specific activity of butyrylcholinesterase, an enzyme involved in the brain's arousal pathway, shortly after...
"Developing procedures for the large-scale purification of human serum butyrylcholinesterase". Protein Expression and Purification. 61 (2): 191–196. doi:10.1016/j...
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