The raphe nuclei (Greek: ῥαφή, "seam")[1] are a moderate-size cluster of nuclei found in the brain stem. They have 5-HT1 receptors which are coupled with Gi/Go-protein-inhibiting adenyl cyclase. They function as autoreceptors in the brain and decrease the release of serotonin. The anxiolytic drug Buspirone acts as partial agonist against these receptors.[2] Selective serotonin reuptake inhibitor (SSRI) antidepressants are believed to act in these nuclei, as well as at their targets.[3]
^Liddell HG, Scott R (1940). A Greek-English Lexicon. Oxford: Clarendon Press. revised and augmented throughout by Sir Henry Stuart Jones with the assistance of Roderick McKenzie
^Siegel GJ, Agranoff BW, Fisher SK, Albers RW, Uhler MD (1999). "Understanding the neuroanatomical organization of serotonergic cells in brain provides insight into the functions of this neurotransmitter". Basic Neurochemistry (Sixth ed.). Lippincott Williams and Wilkins. ISBN 978-0-397-51820-3. In 1964, Dahlstrom and Fuxe (discussed in [2]), using the Falck-Hillarp technique of histofluorescence, observed that the majority of serotonergic soma are found in cell body groups, which previously had been designated as the raphe nuclei.
^Briley M, Moret C (October 1993). "Neurobiological mechanisms involved in antidepressant therapies". Clinical Neuropharmacology. 16 (5): 387–400. doi:10.1097/00002826-199310000-00002. PMID 8221701.
The raphenuclei (Greek: ῥαφή, "seam") are a moderate-size cluster of nuclei found in the brain stem. They have 5-HT1 receptors which are coupled with...
the V. Afferents of the motor nucleus. It is one of two nuclei, the other being the dorsal raphe nucleus (DnR), in the midbrain-pons. The MRN projects extensively...
in the central nervous system (CNS), specifically in the brainstem's raphenuclei, the skin's Merkel cells, pulmonary neuroendocrine cells and the tongue's...
The dorsal raphe nucleus is one of the raphenuclei. It is situated in the brainstem at the midline. It has rostral and caudal subdivisions: The rostral...
are several different significant anatomical raphes: The raphe nucleus is a moderate-size cluster of nuclei found in the brain stem that releases serotonin...
The nucleus raphe magnus (termed the nucleus raphes magnus by Terminologia Anatomica and some publications) is one of the seven raphenuclei. It is situated...
The pontine raphe nucleus is one of the raphenuclei. It is located in the pontine tegmentum. Walker, Emily P.; Tadi, Prasanna (2024), "Neuroanatomy, Nucleus...
function; microinjections of 5-HT into the nucleus raphe obscurus increase gastric movement. Raphenuclei Brodal, A (1981). Neurological Anatomy in relation...
nucleus raphe pallidus receives afferents from the medial preoptic area, median preoptic nucleus and lateral paragigantocellular reticular nuclei. The nucleus...
Monoamine nuclei are clusters of cells that primarily use monoamine neurotransmitters to communicate. The raphenuclei, ventral tegmental area, and locus...
system has almost all of its serotonergic neurons originating in the raphenuclei. This system projects to the limbic system and the prefrontal cortex...
retinohypothalamic tract, geniculohypothalamic tract, and projections from some raphenuclei. The dorsomedial SCN is mainly innervated by the core and also by other...
and sensory (temp, texture, etc.) info. Reticular formation (includes Raphenuclei responsible for serotonin production) is signaled to release serotonin...
GABAergic inputs, cholinergic inputs, and inputs from other monoaminergic nuclei. The VTA contains 5-HT1A receptors that exert a biphasic effects on firing...
Nigrostriatal pathway Tuberoinfundibular pathway Serotonergic pathways RapheNuclei Norepinephrine Pathways Locus coeruleus and other noradrenergic cell...
cerebellum and afferents from the raphenuclei also project to the LC, in particular the pontine raphe nucleus and dorsal raphe nucleus. The locus coeruleus...
tuberomamillary nucleus (TMN), serotonergic raphenuclei, cholinergic laterodorsal and pedunculopontine nuclei (LDT and PPT), and the dopaminergic ventral...
localized to classical brainstem nuclei, particularly the raphenuclei, they are more often referred to by the names of those nuclei than by the B1-9 nomenclature...
enkephalin-releasing neurons that project to the raphenuclei in the brainstem. 5-HT (serotonin) released from the raphenuclei descends to the dorsal horn of the spinal...
observed in Stage 1, Stage 2 is characterized by additional lesions in the raphenuclei and gigantocellular reticular nucleus of the medulla oblongata. The disease...
and mood regulation. ...The rostral nuclei, which include the nucleus linearis, dorsal raphe, medial raphe, and raphe pontis, innervate most of the brain...
hormonally signals reticular formation's raphenuclei to produce serotonin that inhibits laminae pain nuclei. Lateral spinothalamic tract aids in localization...
tuberomamillary nucleus (TMN), serotonergic raphenuclei, cholinergic laterodorsal and pedunculopontine nuclei (LDT and PPT), and the dopaminergic ventral...
locus ceruleus (LC) and related brainstem nuclei; the serotonergic neurons originate from the raphenuclei within the brainstem as well; the dopaminergic...
which is the target for serotonergic output from the dorsal and median raphenuclei playing a role in maintaining the circadian rhythm and regulation of...
These neurons are located in the locus coeruleus, dorsal and median raphenuclei, ventral periaqueductal grey matter, and tuberomammillary nucleus. Each...
releasing peptide [1] Vagal Regulation of Gastric Function Involves Thyrotropin Releasing Hormone in the Medullary RapheNuclei and Dorsal Vagal Complex [2]...
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