Monoamine nuclei are clusters of cells that primarily use monoamine neurotransmitters to communicate. The raphe nuclei, ventral tegmental area, and locus coeruleus have been included in texts about monoamine nuclei.[1] These nuclei receive a variety of inputs including from other monoamines, as well as from glutaminergic, GABAergic, and substance p related pathways. The catacholaminergic pathways mainly project upwards into the cortical and limbic regions, power sparse descending axons have been observed in animals models. Both ascending and descending serotonergic pathways project from the raphe nuclei. Raphe nuclei in the obscurus, pallid us, and magnus descend into the brainstem and spinal cord, while the raphe ponds, raphe dorsals, and nucleus centralism superior projected up into the medial forebrain bundle before branching off.[2] Monoamine nuclei have been studied in relation to major depressive disorder, with some abnormalities observed,[3] however MAO-B levels appear to be normal during depression in these regions.[4]
Locus-coeruleusdopaminergic and serotonergic ascending pathways
^al.], editors, Kenneth L. Davis ... [et (2002). Neuropsychopharmacology : the fifth generation of progress : an official publication of the American College of Neuropsychopharmacology (5th ed.). Philadelphia, Pa.: Lippincott Williams & Wilkins. ISBN 0781728371. {{cite book}}: |first1= has generic name (help)CS1 maint: multiple names: authors list (link)
^Felten, David L.; Sladek Jr., John R. (1 February 1983). "Monoamine distribution in primate brain V. Monoaminergic nuclei: Anatomy, pathways and local organization". Brain Research Bulletin. 10 (2): 171–284. doi:10.1016/0361-9230(83)90045-X. PMID 6839182. S2CID 13176814.
^al.], editors, Kenneth L. Davis ... [et (2002). Neuropsychopharmacology : the fifth generation of progress : an official publication of the American College of Neuropsychopharmacology (5th ed.). Philadelphia, Pa.: Lippincott Williams & Wilkins. ISBN 0781728371. {{cite book}}: |first1= has generic name (help)CS1 maint: multiple names: authors list (link)
^Klimek, Violetta; Roberson, Gary; Stockmeier, Craig A.; Ordway, Gregory A. (1 October 2016). "Serotonin transporter and MAO-B levels in monoamine nuclei of the human brainstem are normal in major depression". Journal of Psychiatric Research. 37 (5): 387–397. doi:10.1016/S0022-3956(03)00045-1. ISSN 0022-3956. PMID 12849931.
Monoaminenuclei are clusters of cells that primarily use monoamine neurotransmitters to communicate. The raphe nuclei, ventral tegmental area, and locus...
amine Trace amine Monoamine nuclei Biology of depression Mele T, Čarman-Kržan M, Jurič DM (2010). "Regulatory role of monoamine neurotransmitters in astrocytic...
serotonin, a type of monoamine neurotransmitter and are modulated through fibrous pathways in the midbrain. Projections from the raphe nuclei also terminate...
(thálamos) 'chamber') is a small part of the vertebrate brain that contains a number of nuclei with a variety of functions. One of the most important functions is to link...
Serotonin (/ˌsɛrəˈtoʊnɪn, ˌsɪərə-/) or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter. Its biological function is complex, touching on diverse...
Monoamine transporters (MATs) are proteins that function as integral plasma-membrane transporters to regulate concentrations of extracellular monoamine...
The parabrachial nuclei, also known as the parabrachial complex, are a group of nuclei in the dorsolateral pons that surrounds the superior cerebellar...
The reticular formation is a set of interconnected nuclei that are located in the brainstem, hypothalamus, and other regions. It is not anatomically well...
A catecholamine (/ˌkætəˈkoʊləmiːn/; abbreviated CA) is a monoamine neurotransmitter, an organic compound that has a catechol (benzene with two hydroxyl...
the breakdown can be catalyzed by either of the enzymes monoamine oxidase (mainly monoamine oxidase A) or COMT. From there, the breakdown can proceed...
of drug abuse are allergic to sympathomimetic amine drugs are taking a monoamine oxidase inhibitor (MAOI) or have taken one within the last 14 days have...
have been suggested over the years, including theories revolving around monoamine neurotransmitters, neuroplasticity, neurogenesis, inflammation and the...
cell. Classes of neurotransmitters include amino acids, monoamines, and peptides. Monoamines are synthesized by altering a single amino acid. For example...
responses. These nuclei are hypothesized to be involved in regulation of monoamines, such as dopamine and serotonin. The habenular nuclei are involved in...
The dorsal raphe nucleus is one of the raphe nuclei. It is situated in the brainstem at the midline. It has rostral and caudal subdivisions: The rostral...
list (link) Felten DL; Sladek JR Jr. (1983). "Monoamine distribution in primate brain V. Monoaminergic nuclei: anatomy, pathways and local organization"...
rodents. Felten DL; Sladek JR Jr. (1983). "Monoamine distribution in primate brain V. Monoaminergic nuclei: anatomy, pathways and local organization"...
naturally as the main pathway for endogenous neurotransmitter synthesis. Monoamine oxidases A and B are the primary enzymes involved in tryptamine metabolism...
OCLC 29952121. Felten DL, Sladek Jr JR (1983). "Monoamine distribution in primate brain V. Monoaminergic nuclei: anatomy, pathways and local organization"...
aggregate projections from neurons which synthesize and communicate the monoamine neurotransmitter serotonin.[citation needed] These pathways are relevant...
S2CID 1022935. Felten DL, Sladek JR Jr (1983). "Monoamine distribution in primate brain V. Monoaminergic nuclei: anatomy, pathways and local organization"...
macaque. Felten DL; Sladek JR Jr. (1983). "Monoamine distribution in primate brain V. Monoaminergic nuclei: anatomy, pathways and local organization"...
cell groups Felten DL; Sladek JR Jr. (1983). "Monoamine distribution in primate brain V. Monoaminergic nuclei: anatomy, pathways and local organization"...
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