Section of the medulla oblongata at about the middle of the olive. (Raphe nuclei not labeled, but 'raphe' labeled at left.)
Details
Identifiers
Latin
nucleus raphe magnus
MeSH
D065846
NeuroNames
739
NeuroLex ID
birnlex_1363
TA98
A14.1.04.321
TA2
6038
FMA
72584
Anatomical terms of neuroanatomy
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The nucleus raphe magnus (termed the nucleus raphes magnus by Terminologia Anatomica[1] and some publications[2]) is one of the seven raphe nuclei. It is situated in the pons in the brainstem,[3]: 306 just rostral to the nucleus raphe obscurus.[citation needed]
The NRM receives afferent stimuli from the enkephalinergic neurons of the periaqueductal gray; the serotonergic neurons of the NRM then bilaterally project efferents to the enkephalinergic and dynorphin-containing interneurons of the substantia gelatinosa of the posterior grey column of the spinal cord. This neural path thus mediates pain perception through pre-synaptic inhibition of first-order afferent (sensory) neurons.[3]: 225
The nucleusraphemagnus (termed the nucleusraphesmagnus by Terminologia Anatomica and some publications) is one of the seven raphe nuclei. It is situated...
The dorsal raphenucleus is one of the raphe nuclei. It is situated in the brainstem at the midline. It has rostral and caudal subdivisions: The rostral...
aqueduct within the tegmentum of the midbrain. It projects to the nucleusraphemagnus, and also contains descending autonomic tracts. The ascending pain...
The nucleusraphe pallidus receives afferent connections from the periaqueductal gray, the Paraventricular nucleus of hypothalamus, central nucleus of...
the periventricular nucleus. They both in turn project to other areas involved in pain regulation, such as the nucleusraphemagnus which also receives...
structures. The caudal group consists of the nucleusraphemagnus (B3), raphe obscurus nucleus (B2), raphe pallidus nucleus (B1), and lateral medullary reticular...
stimulated by a signal, the synaptic connections activate neurons in the nucleusraphemagnus; the pathway then projects down into the posterior grey column of...
cough response. Parts of the caudal medullary raphenucleus (nucleusraphe obscurus and nucleusraphemagnus) are known to be essential for the cough response...
and the axons forming the periaqueductal gray then project to the nucleusraphesmagnus, which projects back down to where the pain signal is coming from...
Group Nucleusraphemagnus (cell group B3) Dorsal column nuclei Posterior grey column Nucleusraphe obscurus (cell group B2) Trigeminal motor nucleus Retrofacial...
decreased the expression of GAD65 in the nucleusraphemagnus, which is in the ventral medulla. The nucleusraphemagnus utilizes HDACs to mediate histone hypoacetylation...
density, with slightly greater densities observed in the nucleusraphesmagnus and the raphe pallidus. In contrast, P2Y1 showed lower levels of labeling...
regulation. ...The rostral nuclei, which include the nucleus linearis, dorsal raphe, medial raphe, and raphe pontis, innervate most of the brain, including...
from the raphe nuclei. Raphe nuclei in the obscurus, pallid us, and magnus descend into the brainstem and spinal cord, while the raphe ponds, raphe dorsals...
the rodent and the primate. Cell group B3 occupies the midline nucleusraphesmagnus and adjacent structures in the caudal medulla oblongata of the rodent...
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