Rhomboid fossa. (Locus coeruleus not labeled, but is very near [just lateral to] the colliculus facialis, which is labeled at center left.)
Micrograph showing the locus coeruleus. HE-LFB stain.
Details
Identifiers
Latin
locus caeruleus ("blue place")
MeSH
D008125
NeuroNames
583
NeuroLex ID
birnlex_905
TA98
A14.1.05.436 A14.1.05.706
TA2
5944
FMA
72478
Anatomical terms of neuroanatomy
[edit on Wikidata]
Locus coeruleus and its influence pathways
The locus coeruleus (/sɪˈruːliəs/) (LC), also spelled locus caeruleus or locus ceruleus,[1] is a nucleus in the pons of the brainstem involved with physiological responses to stress and panic.[2] It is a part of the reticular activating system.
The locus coeruleus, which in Latin means "blue spot", is the principal site for brain synthesis of norepinephrine (noradrenaline). The locus coeruleus and the areas of the body affected by the norepinephrine it produces are described collectively as the locus coeruleus-noradrenergic system or LC-NA system.[3] Norepinephrine may also be released directly into the blood from the adrenal medulla.
^"locus coeruleus | a bluish area of the brain stem with many norepinephrine-containing neurons". www.merriam-webster.com. Retrieved 26 July 2015.
^Morris LS, McCall JG, Charney DS, Murrough JW (21 July 2020). "The role of the locus coeruleus in the generation of pathological anxiety". Brain Neurosci. Adv. 4 (4:2398212820930321). doi:10.1177/2398212820930321. PMC 7479871. PMID 32954002.
^Mehler, Mark F.; Dominick P. Purpura (March 2009). "Autism, fever, epigenetics and the locus coeruleus". Brain Research Reviews. 59 (2): 388–392. doi:10.1016/j.brainresrev.2008.11.001. PMC 2668953. PMID 19059284.
The locuscoeruleus (/sɪˈruːliəs/) (LC), also spelled locus caeruleus or locus ceruleus, is a nucleus in the pons of the brainstem involved with physiological...
effects on other brain areas. The most important of these nuclei is the locuscoeruleus, located in the pons. Outside the brain, norepinephrine is used as...
developmental dysregulation that results in impaired function of the locuscoeruleus–noradrenergic (LC-NA) system. The LC-NA system is heavily involved...
these afferents to the cortex and therefore regulated wakefulness. Locuscoeruleus Pedunculopontine nucleus Medial pontine reticular formation Midbrain...
noradrenaline system consists of around 15,000 neurons, primarily in the locuscoeruleus. This is diminutive compared to the more than 100 billion neurons in...
and locuscoeruleus, giving a dark color to the structures. Neuromelanin gives specific brain sections, such as the substantia nigra or the locus coeruleus...
load or demand. The responses correlate strongly with activity in the locuscoeruleus neurotransmitter system. The pupils contract immediately before REM...
on the locuscoeruleus system. It describes how decision-making processes studied by neuroeconomists as well as activity in the locuscoeruleus system...
hypothesize that the locuscoeruleus is a critical site at which loss of MECP2 results in CNS dysfunction." The restoration of normal locuscoeruleus function may...
sympathetic activation. The nPGi is one of two major afferents of the locuscoeruleus (LC), and sends collateral projections to the LC and to the nucleus...
withdrawal. Upregulation of the cAMP signal transduction pathway in the locuscoeruleus by CREB has been implicated as the mechanism responsible for certain...
The noradrenergic system is a bundle of axons that originate in the locuscoeruleus and ascends up into the neocortex, limbic system, and basal forebrain...
divergent thinking. Convergent and divergent thinking depend on the locuscoeruleus neurotransmission system, which modulates noradrenaline levels in the...
dilation that is produced by transient activity of the subcortical locuscoeruleus. This pupil dilation effect is discussed to indicate a detection of...
originate in the brain stem, especially the pontine tegmentum and locuscoeruleus. REM sleep is punctuated and immediately preceded by PGO (ponto-geniculo-occipital)...
due to the stress of being born and the associated activation of the locuscoeruleus. Dream argument Eugeroic High-conductance state Lucid dream Sleepwalking...
brainstem, the most notable from the nucleus of the solitary tract, the locuscoeruleus, and the ventrolateral medulla. Most nerve fibres within the hypothalamus...
G protein-coupled receptor. Importantly, the dorsal raphe nucleus, locuscoeruleus, and tuberomammillary nucleus contain orexin receptors, are projected...
(CU Boulder). The Adaptive Behaviour Research Group (Sheffield). The locuscoeruleus (LC) is one of the primary sources of noradrenaline in the brain, and...
(labyrinthitis). Dysregulation of the norepinephrine system in the locuscoeruleus, an area of the brain stem, has been linked to panic attacks. Panic...
tegmentum, nucleus basalis of Meynert, raphe nuclei, substantia nigra and locuscoeruleus; p-tau thorn-shaped astrocytes (TSA) in the subpial region; p-tau dot-like...
in arousal, comes exclusively from a nearby small area called the locuscoeruleus. Other neurotransmitters such as acetylcholine and dopamine have multiple...
project out of the VTA and SNc. Noradrenergic inputs deriving from the locuscoeruleus have excitatory and inhibitory effects on the dopaminergic neurons...
occurs after. Studies in mice show neuronal death (in the hippocampus, locuscoeruleus, and medial PFC) occurs after two days of REM sleep deprivation. However...
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