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Locus coeruleus information


Locus coeruleus
Rhomboid fossa. (Locus coeruleus not labeled, but is very near [just lateral to] the colliculus facialis, which is labeled at center left.)
Micrograph showing the locus coeruleus. HE-LFB stain.
Details
Identifiers
Latinlocus caeruleus ("blue place")
MeSHD008125
NeuroNames583
NeuroLex IDbirnlex_905
TA98A14.1.05.436
A14.1.05.706
TA25944
FMA72478
Anatomical terms of neuroanatomy
[edit on Wikidata]
Locus coeruleus and its influence pathways

The locus coeruleus (/sɪˈrliəs/) (LC), also spelled locus caeruleus or locus ceruleus,[1] is a nucleus in the pons of the brainstem involved with physiological responses to stress and panic.[2] It is a part of the reticular activating system.

The locus coeruleus, which in Latin means "blue spot", is the principal site for brain synthesis of norepinephrine (noradrenaline). The locus coeruleus and the areas of the body affected by the norepinephrine it produces are described collectively as the locus coeruleus-noradrenergic system or LC-NA system.[3] Norepinephrine may also be released directly into the blood from the adrenal medulla.

  1. ^ "locus coeruleus | a bluish area of the brain stem with many norepinephrine-containing neurons". www.merriam-webster.com. Retrieved 26 July 2015.
  2. ^ Morris LS, McCall JG, Charney DS, Murrough JW (21 July 2020). "The role of the locus coeruleus in the generation of pathological anxiety". Brain Neurosci. Adv. 4 (4:2398212820930321). doi:10.1177/2398212820930321. PMC 7479871. PMID 32954002.
  3. ^ Mehler, Mark F.; Dominick P. Purpura (March 2009). "Autism, fever, epigenetics and the locus coeruleus". Brain Research Reviews. 59 (2): 388–392. doi:10.1016/j.brainresrev.2008.11.001. PMC 2668953. PMID 19059284.

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Locus coeruleus

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The locus coeruleus (/sɪˈruːliəs/) (LC), also spelled locus caeruleus or locus ceruleus, is a nucleus in the pons of the brainstem involved with physiological...

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Norepinephrine

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effects on other brain areas. The most important of these nuclei is the locus coeruleus, located in the pons. Outside the brain, norepinephrine is used as...

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Reticular formation

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these afferents to the cortex and therefore regulated wakefulness. Locus coeruleus Pedunculopontine nucleus Medial pontine reticular formation Midbrain...

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Causes of autism

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developmental dysregulation that results in impaired function of the locus coeruleus–noradrenergic (LC-NA) system. The LC-NA system is heavily involved...

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Neuromodulation

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noradrenaline system consists of around 15,000 neurons, primarily in the locus coeruleus. This is diminutive compared to the more than 100 billion neurons in...

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Rett syndrome

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hypothesize that the locus coeruleus is a critical site at which loss of MECP2 results in CNS dysfunction." The restoration of normal locus coeruleus function may...

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Neuromelanin

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and locus coeruleus, giving a dark color to the structures. Neuromelanin gives specific brain sections, such as the substantia nigra or the locus coeruleus...

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Pupillary response

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load or demand. The responses correlate strongly with activity in the locus coeruleus neurotransmitter system. The pupils contract immediately before REM...

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Creativity

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on the locus coeruleus system. It describes how decision-making processes studied by neuroeconomists as well as activity in the locus coeruleus system...

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Nucleus paragigantocellularis

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sympathetic activation. The nPGi is one of two major afferents of the locus coeruleus (LC), and sends collateral projections to the LC and to the nucleus...

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Arousal

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The noradrenergic system is a bundle of axons that originate in the locus coeruleus and ascends up into the neocortex, limbic system, and basal forebrain...

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Substance dependence

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withdrawal. Upregulation of the cAMP signal transduction pathway in the locus coeruleus by CREB has been implicated as the mechanism responsible for certain...

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Hypothalamus

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brainstem, the most notable from the nucleus of the solitary tract, the locus coeruleus, and the ventrolateral medulla. Most nerve fibres within the hypothalamus...

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Oddball paradigm

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dilation that is produced by transient activity of the subcortical locus coeruleus. This pupil dilation effect is discussed to indicate a detection of...

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Convergent thinking

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divergent thinking. Convergent and divergent thinking depend on the locus coeruleus neurotransmission system, which modulates noradrenaline levels in the...

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Pediatric narcolepsy

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G protein-coupled receptor. Importantly, the dorsal raphe nucleus, locus coeruleus, and tuberomammillary nucleus contain orexin receptors, are projected...

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Rapid eye movement sleep

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originate in the brain stem, especially the pontine tegmentum and locus coeruleus. REM sleep is punctuated and immediately preceded by PGO (ponto-geniculo-occipital)...

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Melanin

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pigment-bearing neurons within areas of the brainstem, such as the locus coeruleus. It also occurs in the zona reticularis of the adrenal gland. The melanin...

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List of regions in the human brain

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Pontine tegmentum Pontine micturition center (Barrington's nucleus) Locus coeruleus Pedunculopontine nucleus Laterodorsal tegmental nucleus Tegmental pontine...

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Dopaminergic pathways

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project out of the VTA and SNc. Noradrenergic inputs deriving from the locus coeruleus have excitatory and inhibitory effects on the dopaminergic neurons...

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Wakefulness

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due to the stress of being born and the associated activation of the locus coeruleus. Dream argument Eugeroic High-conductance state Lucid dream Sleepwalking...

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Panic attack

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(labyrinthitis). Dysregulation of the norepinephrine system in the locus coeruleus, an area of the brain stem, has been linked to panic attacks. Panic...

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Action selection

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(CU Boulder). The Adaptive Behaviour Research Group (Sheffield). The locus coeruleus (LC) is one of the primary sources of noradrenaline in the brain, and...

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Catecholamine

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neurons. The similarly neuromelanin-pigmented cell bodies of the locus coeruleus produce norepinephrine. Epinephrine is produced in small groups of...

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Sleep deprivation

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occurs after. Studies in mice show neuronal death (in the hippocampus, locus coeruleus, and medial PFC) occurs after two days of REM sleep deprivation. However...

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