positive regulation of NF-kappaB transcription factor activity
angiogenesis
positive regulation of blood vessel endothelial cell migration
positive regulation of neuron projection development
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
integrin-mediated signaling pathway
protein autophosphorylation
cellular response to oxidative stress
cellular response to vascular endothelial growth factor stimulus
Ras protein signal transduction
cell population proliferation
inflammatory response
innate immune response
signal transduction
positive regulation of transcription by RNA polymerase II
apoptotic process
positive regulation of autophagy
cellular response to amino acid starvation
positive regulation of phosphatidylinositol 3-kinase activity
cellular response to hydroperoxide
regulation of keratinocyte proliferation
positive regulation of osteoblast differentiation
Golgi vesicle transport
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
5587
18760
Ensembl
ENSG00000184304
ENSMUSG00000002688
UniProt
Q15139
Q62101
RefSeq (mRNA)
NM_002742 NM_001330069 NM_001348390
NM_008858
RefSeq (protein)
NP_001316998 NP_002733 NP_001335319
NP_032884 NP_001369743 NP_001369744 NP_001369745
Location (UCSC)
Chr 14: 29.58 – 30.19 Mb
Chr 12: 50.34 – 50.65 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Serine/threonine-protein kinase D1 is an enzyme that in humans is encoded by the PRKD1 gene.[5][6][7]
^ abcGRCh38: Ensembl release 89: ENSG00000184304 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000002688 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Johannes FJ, Prestle J, Eis S, Oberhagemann P, Pfizenmaier K (April 1994). "PKCu is a novel, atypical member of the protein kinase C family". J Biol Chem. 269 (8): 6140–8. doi:10.1016/S0021-9258(17)37580-4. PMID 8119958.
^Owczarek CM, Portbury KJ, Kola I, Hertzog PJ (September 2000). "Assignment of protein kinase C mu (PRKCM) to human chromosome band 14q11 with somatic cell hybrids and radiation hybrids". Cytogenet Cell Genet. 89 (3–4): 240–1. doi:10.1159/000015624. PMID 10965134. S2CID 26620985.
D1 is composed of the following protein domains and motifs: retinoblastoma protein (pRb) binding motif; cyclin box domain for cyclin-dependent kinase...
unique tyrosine kinase genes identified in the human genome, 58 encode receptor tyrosine kinaseproteins. Receptor tyrosine kinases have been shown not...
regulation of cyclin D1 and cyclin-dependent kinase inhibitors (p21 and p27) expression. These regulation pathways activate proteinkinases, which subsequently...
cAMP mediated proteinkinase A activity also results in the phosphorylation of DARPP-32, an inhibitor of protein phosphatase 1. Sustained D1 receptor activity...
messenger cAMP, which in turn activates the cAMP-dependent proteinkinase (also called ProteinKinase A or PKA). Cellular effects of Gsα acting through PKA...
Dopamine receptor D1, also known as DRD1. It is one of the two types of D1-like receptor family — receptors D1 and D5. It is a protein that in humans is...
Vertebrate MRF family members include MyoD1, Myf5, myogenin, and MRF4 (Myf6). In non-vertebrate animals, a single MyoD protein is typically found. MyoD is one...
kinases such as the Akt/Rac family, proteinkinaseD1, and the trypanosomal NrkA family. Non-receptor tyrosine kinases belonging to the Btk/Itk/Tec subfamily...
serine/threonine-specific proteinkinase that belongs to the family of phosphatidylinositol-3 kinase (PI3K) related kinases (PIKKs). mTOR regulates cellular...
produces a family of proteins known as p53. It, combined with the Ras pathway, downregulate cyclin D1, a cyclin-dependent kinase, if they are not stimulated...
p16INK4a, cyclin-dependent kinase inhibitor 2A, CDKN2A, multiple tumor suppressor 1 and numerous other synonyms), is a protein that slows cell division...
PRKAA1 NM_006251 Catalytic subunit of AMP-activated proteinkinase (AMPK), an energy sensor proteinkinase that plays a key role in regulating cellular energy...
Serine/threonine kinase 11 (STK11) also known as liver kinase B1 (LKB1) or renal carcinoma antigen NY-REN-19 is a proteinkinase that in humans is encoded...
Serine/threonine-proteinkinase N1 is an enzyme that in humans is encoded by the PKN1 gene. The protein encoded by this gene belongs to the proteinkinase C superfamily...
binding sites as found in enzymes or regulatory proteins. An appropriate example is pyruvate kinase (see first figure), a glycolytic enzyme that plays...
Proteinkinase C alpha (PKCα) is an enzyme that in humans is encoded by the PRKCA gene. Proteinkinase C (PKC) is a family of serine- and threonine-specific...
G protein-coupled receptor kinase 4 (GRK4) is an enzyme that is encoded by the GRK4 gene in humans. This gene encodes a member of the G protein-coupled...
referred to as proteinkinase B, phosphorylates FOXO1 and accumulates in the cytosol. Casein kinase 1, a growth factor-activated proteinkinase, also phosphorylates...