CD135 information

FLT3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1RJB, 3QS7, 3QS9, 4RT7, 4XUF
Identifiers
Aliases	FLT3, CD135, FLK-2, FLK2, STK1, fms related tyrosine kinase 3, fms related receptor tyrosine kinase 3
External IDs	OMIM: 136351 MGI: 95559 HomoloGene: 3040 GeneCards: FLT3
Gene location (Human)
Chr.	Chromosome 13 (human)
End	28,100,592 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	147,337,299 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; monocyte; ; bone marrow cells; ; lymph node; ; body of pancreas; ; spleen; ; appendix; ; gallbladder; ; right lung; ; blood;
	Top expressed in
	superior olivary complex; ; facial motor nucleus; ; red nucleus; ; cochlear nuclei; ; motor neuron; ; Region IV of hippocampus proper; ; Purkinje cell; ; anterior horn of spinal cord; ; nerve; ; inferior colliculus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	vascular endothelial growth factor-activated receptor activity; nucleotide binding; protein kinase activity; transferase activity; protein homodimerization activity; kinase activity; protein binding; cytokine receptor activity; transmembrane receptor protein tyrosine kinase activity; protein tyrosine kinase activity; ATP binding; protein self-association; protein-containing complex binding; glucocorticoid receptor binding; 1-phosphatidylinositol-3-kinase activity; receptor tyrosine kinase; transmembrane signaling receptor activity;
Cellular component	cytoplasm; integral component of membrane; cytosol; endoplasmic reticulum lumen; membrane; integral component of plasma membrane; nucleus; plasma membrane; endoplasmic reticulum; protein-containing complex; receptor complex;
Biological process	leukocyte homeostasis; regulation of apoptotic process; dendritic cell differentiation; cell differentiation; myeloid progenitor cell differentiation; positive regulation of MAP kinase activity; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; common myeloid progenitor cell proliferation; positive regulation of tyrosine phosphorylation of STAT protein; cellular response to cytokine stimulus; positive regulation of phosphatidylinositol 3-kinase activity; protein phosphorylation; pro-B cell differentiation; cellular response to glucocorticoid stimulus; animal organ regeneration; response to organonitrogen compound; positive regulation of cell population proliferation; lymphocyte proliferation; protein autophosphorylation; positive regulation of phosphatidylinositol 3-kinase signaling; peptidyl-tyrosine phosphorylation; B cell differentiation; positive regulation of MAPK cascade; vascular endothelial growth factor signaling pathway; cytokine-mediated signaling pathway; hemopoiesis; MAPK cascade; phosphatidylinositol-3-phosphate biosynthetic process; negative regulation of signal transduction; viral process; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; hematopoietic progenitor cell differentiation; leukocyte differentiation; lymphocyte differentiation;
	Sources:Amigo / QuickGO
Orthologs
	2322
	14255
	ENSG00000122025
	ENSMUSG00000042817
	P36888
	Q00342
	NM_004119
	NM_010229
	NP_004110
	NP_034359
	Wikidata
View/Edit Human	View/Edit Mouse

Cluster of differentiation antigen 135 (CD135) also known as fms like tyrosine kinase 3 (FLT-3 with fms standing for "feline McDonough sarcoma"), receptor-type tyrosine-protein kinase FLT3, or fetal liver kinase-2 (Flk2) is a protein that in humans is encoded by the FLT3 gene. FLT3 is a cytokine receptor which belongs to the receptor tyrosine kinase class III. CD135 is the receptor for the cytokine Flt3 ligand (FLT3L).

It is expressed on the surface of many hematopoietic progenitor cells. Signalling of FLT3 is important for the normal development of haematopoietic stem cells and progenitor cells.

The FLT3 gene is one of the most frequently mutated genes in acute myeloid leukemia (AML).^[5] High levels of wild-type FLT3 have been reported for blast cells of some AML patients without FLT3 mutations. These high levels may be associated with worse prognosis.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000122025 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042817 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yamamoto Y, Kiyoi H, Nakano Y, Suzuki R, Kodera Y, Miyawaki S, Asou N, Kuriyama K, Yagasaki F, Shimazaki C, Akiyama H, Saito K, Nishimura M, Motoji T, Shinagawa K, Takeshita A, Saito H, Ueda R, Ohno R, Naoe T (April 2001). "Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies". Blood. 97 (8): 2434–9. doi:10.1182/blood.V97.8.2434. PMID 11290608.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000122025 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042817 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11290608-5] Yamamoto Y, Kiyoi H, Nakano Y, Suzuki R, Kodera Y, Miyawaki S, Asou N, Kuriyama K, Yagasaki F, Shimazaki C, Akiyama H, Saito K, Nishimura M, Motoji T, Shinagawa K, Takeshita A, Saito H, Ueda R, Ohno R, Naoe T (April 2001). "Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies". Blood. 97 (8): 2434–9. doi:10.1182/blood.V97.8.2434. PMID 11290608.

CD135 information

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