Pimagedine information

Pimagedine
Skeletal formula of a pimagedine	Spacefill model of a pimagedine
Names
	IUPAC name 2-Aminoguanidine
	Other names Aminoguanidine; Guanyl hydrazine; Hydrazinecarboximidamide; Imino semicarbazide; Monoaminoguanidine;
Identifiers
CAS Number	79-17-4 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL225304 ;
ChemSpider	2061 ;
ECHA InfoCard	100.001.076
IUPHAR/BPS	5135;
KEGG	D05479;
PubChem CID	2146;
UNII	SCQ4EZQ113 ;
CompTox Dashboard (EPA)	DTXSID5040964 ;
	InChI InChI=1S/CH6N4/c2-1(3)5-4/h1,4H,2-3H2 Key: DRCHNMARIZRTKI-UHFFFAOYSA-N ;
	SMILES NC(N)N=N;
Properties
Chemical formula	CH6N4
Molar mass	74.085 g/mol
Density	1.72 g/ml
Boiling point	261 °C (502 °F; 534 K)
log P	−1.475
Related compounds
Related compounds	Guanidine
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Pimagedine, also known as aminoguanidine, is an investigational drug for the treatment of diabetic nephropathy that is no longer under development as a drug.^[1] Pimagedine functions as an inhibitor of diamine oxidase and nitric oxide synthase. It acts to reduce levels of advanced glycation end products (AGEs) through interacting with 3-deoxyglucosone, glyoxal, methylglyoxal, and related dicarbonyls. These reactive species are converted to less reactive heterocycles by this condensation reaction.

^ Thornalley, Paul J. (2003). "Use of aminoguanidine (Pimagedine) to prevent the formation of advanced glycation endproducts". Archives of Biochemistry and Biophysics. 419 (1): 31–40. doi:10.1016/j.abb.2003.08.013. PMID 14568006.

[1] Thornalley, Paul J. (2003). "Use of aminoguanidine (Pimagedine) to prevent the formation of advanced glycation endproducts". Archives of Biochemistry and Biophysics. 419 (1): 31–40. doi:10.1016/j.abb.2003.08.013. PMID 14568006.

Pimagedine information

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Pimagedine

Tobacco

Biological functions of nitric oxide

Alkyl nitrite

Sildenafil

Nitrate

Nitrosamine

Amyl nitrite

Nitrate ester

Butyl nitrite

Nitric oxide

Methylene blue

Exhaled nitric oxide

Arginine

Isobutyl nitrite

Isopropyl nitrite

Monoamine oxidase inhibitor

Ethyl nitrite

Moclobemide

Isosorbide dinitrate

PDE5 inhibitor

Linezolid

Guanylate cyclase

Indazole

Nitrosonium

Nitroglycerin

Vericiguat

Cyclododecanone