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Antidepressant
Moclobemide
Clinical data
Trade names
Amira, Aurorix, Clobemix, Depnil, Manerix, others
AHFS/Drugs.com
Micromedex Detailed Consumer Information
Pregnancy category
AU: B3
Routes of administration
By mouth
ATC code
N06AG02 (WHO)
Legal status
Legal status
AU: S4 (Prescription only)
BR: Class C1 (Other controlled substances)[1]
CA: ℞-only
UK: POM (Prescription only)
Pharmacokinetic data
Bioavailability
55–95% (increases with repeat administration)[2][3]
Moclobemide, sold under the brand names Amira, Aurorix,[8]Clobemix, Depnil and Manerix[9] among others, is a reversible inhibitor of monoamine oxidase A (RIMA) drug primarily used to treat depression and social anxiety.[10][11][12] It is not approved for use in the United States,[13] but is approved in other Western countries such as Canada, the UK[12] and Australia.[14] It is produced by affiliates of the Hoffmann–La Roche pharmaceutical company. Initially, Aurorix was also marketed by Roche in South Africa, but was withdrawn after its patent rights expired and Cipla Medpro's Depnil and Pharma Dynamic's Clorix became available at half the cost.
No significant rise in blood pressure occurs when moclobemide is combined with amines such as tyramine-containing foods or pressor amine drugs, unlike with the older irreversible and non-selective monoamine oxidase inhibitors (MAOIs), which cause a severe rise in blood pressure with such combination.[10] Due to the lack of anticholinergic, cardiovascular, cognitive and psychomotor impairments moclobemide is advantageous in the elderly as well as those with cardiovascular disease.[10]
^Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
^Cite error: The named reference pmid1377119 was invoked but never defined (see the help page).
^ abSchoerlin MP, Mayersohn M, Korn A, Eggers H (October 1987). "Disposition kinetics of moclobemide, a monoamine oxidase-A enzyme inhibitor: single and multiple dosing in normal subjects". Clinical Pharmacology and Therapeutics. 42 (4): 395–404. doi:10.1038/clpt.1987.169. PMID 3665338. S2CID 46130982.
^ abCite error: The named reference pmid2248087 was invoked but never defined (see the help page).
^Gex-Fabry M, Balant-Gorgia AE, Balant LP (February 1995). "Potential of concentration monitoring data for a short half-life drug: analysis of pharmacokinetic variability for moclobemide". Therapeutic Drug Monitoring. 17 (1): 39–46. doi:10.1097/00007691-199502000-00007. PMID 7725375. S2CID 7044652.
^Cite error: The named reference pmid2248086 was invoked but never defined (see the help page).
^Scheen AJ (May 1994). "[Drug of the month. Moclobemide (Aurorix)]". Revue Médicale de Liège (in French). 49 (5): 291–292. PMID 8023056.
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^ abcCite error: The named reference pmid8875133 was invoked but never defined (see the help page).
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Moclobemide, sold under the brand names Amira, Aurorix, Clobemix, Depnil and Manerix among others, is a reversible inhibitor of monoamine oxidase A (RIMA)...
used in the treatment of Parkinson's disease) and the reversible MAOI moclobemide provide a safer alternative and are now sometimes used as first-line...
harmine, although caution must be taken when choosing an MAOI. The use of moclobemide, a reversible inhibitor of monoamine oxidase-A (RIMA), has been recorded...
agitation or anxiety and has similar efficacy to the antidepressant drug moclobemide. This finding has also been validated by a group of general practitioners...
citalopram in resistant OCD. Citalopram is well tolerated and as effective as moclobemide in social anxiety disorder. There are studies suggesting that citalopram...
Eprobemide differs from moclobemide only in the linker that connects the morpholine fragment with the chlorobenzamide — moclobemide has two carbon atoms...
drug, moclobemide. "Hyperorgasmia". Archived from the original on 2012-04-26. Retrieved 2011-12-26. Lauerma H (June 1995). "A case of moclobemide-induced...
treatment of depression, it has demonstrated similar efficacy to the MAOI moclobemide. It has also been used to treat nocturnal enuresis because of its ability...
reuptake inhibitors, the serotonin-norepinephrine reuptake inhibitors, moclobemide and numerous others) it may also have a beneficial effect on cognition...
and 73%, mirtazapine 24%, nefazodone 8%, amineptine 7%, and moclobemide 4%. Moclobemide, a selective reversible MAO-A inhibitor, does not cause sexual...
patients. There are also newer selective and reversible MAOIs, such as moclobemide, which carry a much lower risk of tyramine potentiation and have fewer...
inhibitors, such as phenelzine (Nardil), tranylcypromine (Parnate), or moclobemide (Aurorix, Manerix). Serotonin reuptake inhibitors such as citalopram...
demonstrated that sertraline is similar in efficacy against depression to moclobemide, nefazodone, escitalopram, bupropion, citalopram, fluvoxamine, paroxetine...
while impaired. Compared to the reversible MAOI antidepressant drug moclobemide, more impairment of vigilance occurs with trazodone. Trazodone has been...
bupropion, mirtazapine, tianeptine, agomelatine, tranylcypromine and moclobemide). Several studies have suggested that SSRIs may adversely affect semen...
suggests that monoamine oxidase inhibitors (MAOIs) such as pirlindole and moclobemide are moderately effective for reducing pain. Very low-quality evidence...
(flumazenil), for the reversal of acute benzodiazepine effects. Aurorix (moclobemide), for depression. Avastin (bevacizumab), for certain malignant tumours...
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