Peripherin is a type III intermediate filament protein expressed mainly in neurons of the peripheral nervous system. It is also found in neurons of the central nervous system that have projections toward peripheral structures, such as spinal motor neurons. Its size, structure, and sequence/location of protein motifs is similar to other type III intermediate filament proteins such as desmin, vimentin and glial fibrillary acidic protein. Like these proteins, peripherin can self-assemble to form homopolymeric filamentous networks (networks formed from peripherin protein dimers), but it can also heteropolymerize with neurofilaments in several neuronal types. This protein in humans is encoded by the PRPH gene.[5][6] Peripherin is thought to play a role in neurite elongation during development and axonal regeneration after injury, but its exact function is unknown. It is also associated with some of the major neuropathologies that characterize amyotropic lateral sclerosis (ALS), but despite extensive research into how neurofilaments and peripherin contribute to ALS, their role in this disease is still unidentified.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000135406 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000023484 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: Peripherin".
^Moncla A, Landon F, Mattei MG, Portier MM (April 1992). "Chromosomal localisation of the mouse and human peripherin genes". Genetical Research. 59 (2): 125–9. doi:10.1017/s0016672300030330. PMID 1378416.
^Liem RK, Messing A (July 2009). "Dysfunctions of neuronal and glial intermediate filaments in disease". The Journal of Clinical Investigation. 119 (7): 1814–24. doi:10.1172/JCI38003. PMC 2701870. PMID 19587456.
Peripherin is a type III intermediate filament protein expressed mainly in neurons of the peripheral nervous system. It is also found in neurons of the...
Peripherin-2 is a protein, that in humans is encoded by the PRPH2 gene. Peripherin-2 is found in the rod and cone cells of the retina of the eye. Defects...
expressed in epithelia. Type III contains the proteins vimentin, desmin, peripherin and glial fibrillary acidic protein (GFAP). Type IV consists of the neurofilament...
three non-epithelial type III IF family members, vimentin, desmin and peripherin, which are all involved in the structure and function of the cell's cytoskeleton...
fibrillary acidic protein (GFAP) is found in astrocytes and other glia. Peripherin found in peripheral neurons. Vimentin, the most widely distributed of...
homodimers or can heterodimerize with another photoreceptor protein, peripherin-2 (PRPH2; retinal degeneration, slow; RDS). It is essential for disk morphogenesis...
loss. The RDS gene provides instructions for making a protein called peripherin. This protein is essential for the normal function of light-sensing (photoreceptor)...
Global Information
