negative regulation of neuron projection development
astrocyte development
extracellular matrix organization
neuron projection regeneration
intermediate filament-based process
regulation of neurotransmitter uptake
Bergmann glial cell differentiation
positive regulation of glial cell proliferation
long-term potentiation
regulation of chaperone-mediated autophagy
intermediate filament organization
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
2670
14580
Ensembl
ENSG00000131095
ENSMUSG00000020932
UniProt
P14136
P03995
RefSeq (mRNA)
NM_002055 NM_001131019 NM_001242376 NM_001363846
NM_001131020 NM_010277
RefSeq (protein)
NP_001124491 NP_001229305 NP_002046 NP_001350775
NP_001124492 NP_034407
Location (UCSC)
Chr 17: 44.9 – 44.92 Mb
Chr 11: 102.78 – 102.79 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Glial fibrillary acidic protein (GFAP) is a protein that is encoded by the GFAP gene in humans.[5] It is a type III intermediate filament (IF) protein that is expressed by numerous cell types of the central nervous system (CNS), including astrocytes[6] and ependymal cells during development.[7] GFAP has also been found to be expressed in glomeruli and peritubular fibroblasts taken from rat kidneys,[8] Leydig cells of the testis in both hamsters[9] and humans,[10] human keratinocytes,[11] human osteocytes and chondrocytes[12] and stellate cells of the pancreas and liver in rats.[13]
GFAP is closely related to the other three non-epithelial type III IF family members, vimentin, desmin and peripherin, which are all involved in the structure and function of the cell's cytoskeleton. GFAP is thought to help to maintain astrocyte mechanical strength[14] as well as the shape of cells, but its exact function remains poorly understood, despite the number of studies using it as a cell marker. The protein was named and first isolated and characterized by Lawrence F. Eng in 1969.[15] In humans, it is located on the long arm of chromosome 17.[16]
^ abcGRCh38: Ensembl release 89: ENSG00000131095 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000020932 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Isaacs A, Baker M, Wavrant-De Vrièze F, Hutton M (July 1998). "Determination of the gene structure of human GFAP and absence of coding region mutations associated with frontotemporal dementia with parkinsonism linked to chromosome 17". Genomics. 51 (1): 152–154. doi:10.1006/geno.1998.5360. PMID 9693047.
^Jacque CM, Vinner C, Kujas M, Raoul M, Racadot J, Baumann NA (January 1978). "Determination of glial fibrillary acidic protein (GFAP) in human brain tumors". Journal of the Neurological Sciences. 35 (1): 147–155. doi:10.1016/0022-510x(78)90107-7. PMID 624958. S2CID 10224197.
^Roessmann U, Velasco ME, Sindely SD, Gambetti P (October 1980). "Glial fibrillary acidic protein (GFAP) in ependymal cells during development. An immunocytochemical study". Brain Research. 200 (1): 13–21. doi:10.1016/0006-8993(80)91090-2. PMID 6998542. S2CID 38131934.
^Buniatian G, Traub P, Albinus M, Beckers G, Buchmann A, Gebhardt R, Osswald H (January 1998). "The immunoreactivity of glial fibrillary acidic protein in mesangial cells and podocytes of the glomeruli of rat kidney in vivo and in culture". Biology of the Cell. 90 (1): 53–61. doi:10.1016/s0248-4900(98)80232-3. PMID 9691426. S2CID 31851422.
^Maunoury R, Portier MM, Léonard N, McCormick D (December 1991). "Glial fibrillary acidic protein immunoreactivity in adrenocortical and Leydig cells of the Syrian golden hamster (Mesocricetus auratus)". Journal of Neuroimmunology. 35 (1–3): 119–129. doi:10.1016/0165-5728(91)90167-6. PMID 1720132. S2CID 3766335.
^Davidoff MS, Middendorff R, Köfüncü E, Müller D, Jezek D, Holstein AF (2002). "Leydig cells of the human testis possess astrocyte and oligodendrocyte marker molecules". Acta Histochemica. 104 (1): 39–49. doi:10.1078/0065-1281-00630. PMID 11993850.
^von Koskull H (1984). "Rapid identification of glial cells in human amniotic fluid with indirect immunofluorescence". Acta Cytologica. 28 (4): 393–400. PMID 6205529.
^Kasantikul V, Shuangshoti S (May 1989). "Positivity to glial fibrillary acidic protein in bone, cartilage, and chordoma". Journal of Surgical Oncology. 41 (1): 22–26. doi:10.1002/jso.2930410109. PMID 2654484. S2CID 34069861.
^Apte MV, Haber PS, Applegate TL, Norton ID, McCaughan GW, Korsten MA, et al. (July 1998). "Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture". Gut. 43 (1): 128–133. doi:10.1136/gut.43.1.128. PMC 1727174. PMID 9771417.
^Cullen DK, Simon CM, LaPlaca MC (July 2007). "Strain rate-dependent induction of reactive astrogliosis and cell death in three-dimensional neuronal-astrocytic co-cultures". Brain Research. 1158: 103–115. doi:10.1016/j.brainres.2007.04.070. PMC 3179863. PMID 17555726.
^Bongcam-Rudloff E, Nistér M, Betsholtz C, Wang JL, Stenman G, Huebner K, et al. (March 1991). "Human glial fibrillary acidic protein: complementary DNA cloning, chromosome localization, and messenger RNA expression in human glioma cell lines of various phenotypes". Cancer Research. 51 (5): 1553–1560. PMID 1847665.
and 27 Related for: Glial fibrillary acidic protein information
Glialfibrillaryacidicprotein (GFAP) is a protein that is encoded by the GFAP gene in humans. It is a type III intermediate filament (IF) protein that...
Jessen KR, Mirsky R (August 1980). "Glial cells in the enteric nervous system contain glialfibrillaryacidicprotein". Nature. 286 (5774): 736–7. Bibcode:1980Natur...
analysis; many of these cells express the intermediate filament glialfibrillaryacidicprotein (GFAP). Several forms of astrocytes exist in the central nervous...
cell organells like the desmosomes with the cytoskeleton. Glialfibrillaryacidicprotein (GFAP) is found in astrocytes and other glia. Peripherin found...
vimentin, desmin, peripherin and glialfibrillaryacidicprotein (GFAP). Type IV consists of the neurofilament proteins NF-L, NF-M, NF-H and α-internexin...
sequence/location of protein motifs is similar to other type III intermediate filament proteins such as desmin, vimentin and glialfibrillaryacidicprotein. Like these...
filament vimentin, and, in some instances, including humans, glialfibrillaryacidicprotein (GFAP). After this transition, radial glia retain many of the...
the immune system of the patient attacks a protein of the nervous system called glialfibrillaryacidicprotein (GFAP). It was described in 2016 by researchers...
Bongcam-Rudloff E, Gobl A (August 2002). "Menin's interaction with glialfibrillaryacidicprotein and vimentin suggests a role for the intermediate filament...
The cytoskeleton is a complex, dynamic network of interlinking protein filaments present in the cytoplasm of all cells, including those of bacteria and...
other glial cells researchers have used markers to identify which proteins are found in different cells. Although SGCs express glialfibrillaryacidic protein...
neuronal Ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) and Glialfibrillaryacidicprotein (GFAP) to aid in the diagnosis of the presence of cranial lesion(s)...
autoantibodies. Immunoglobulins directed against the α-isoform of glialfibrillaryacidicprotein (GFAP-IgG) predicted a special meningoencephalomyelitis termed...
of glial cell: the astrocyte. Like astrocytes, their cytoplasm presents specific intermediate filaments made up of glialfibrillaryacidicprotein (GFAP)...
filament proteins, primarily glialfibrillaryacidicprotein. Other reported constituents include alphaB crystallin, heat shock protein 27, protein beta-1)...
The glia limitans, or the glial limiting membrane, is a thin barrier of astrocyte foot processes associated with the parenchymal basal lamina surrounding...
from the accumulation of Glialfibrillaryacidicprotein (GFAP) as the result of a mutation in the GFAP gene, whose protein, rather than being found in...
they are S-100 protein negative. The sustentacular cells are S-100 positive and focally positive for glialfibrillaryacidicprotein. By histochemistry...
([pref. protein]; -pathy [suff. disease]; proteinopathies pl.; proteinopathic adj), or proteopathy, protein conformational disorder, or protein misfolding...
highlighted with S100 protein and with glial fibrillaryacidicprotein, although the latter is much more sensitive for glial tissue. The most common missed lesion...
ultimately, glial scar formation. The severity of astrogliosis is classically determined by the level of expression of glialfibrillaryacidicprotein (GFAP)...
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