Type IV intermediate filaments found in the cytoplasm of neurons
NF-L low molecular weight neurofilament protein
Identifiers
Symbol
NEFL
NCBI gene
4747
HGNC
7739
OMIM
162280
RefSeq
NM_006158
UniProt
P07196
Other data
Locus
Chr. 8 p21
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Structures
Swiss-model
Domains
InterPro
NF-M medium molecular weight neurofilament protein
Identifiers
Symbol
NEFM
Alt. symbols
NEF3
NCBI gene
4741
HGNC
7734
OMIM
162250
RefSeq
NM_005382
UniProt
P07197
Other data
Locus
Chr. 8 p21
Search for
Structures
Swiss-model
Domains
InterPro
NF-H high molecular weight neurofilament protein
Identifiers
Symbol
NEFH
NCBI gene
4744
HGNC
7737
OMIM
162230
RefSeq
NM_021076
UniProt
P12036
Other data
Locus
Chr. 22 q12.1-13.1
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Structures
Swiss-model
Domains
InterPro
Alpha-internexin neuronal intermediate filament protein
Identifiers
Symbol
INA
Alt. symbols
NEF5
NCBI gene
9118
HGNC
6057
OMIM
605338
RefSeq
NM_032727
UniProt
Q5SYD2
Other data
Locus
Chr. 10 q24
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Structures
Swiss-model
Domains
InterPro
Peripherin neuronal intermediate filament protein
Identifiers
Symbol
PRPH
Alt. symbols
NEF4
NCBI gene
5630
HGNC
9461
OMIM
170710
RefSeq
NM_006262.3
UniProt
P41219
Other data
Locus
Chr. 12 q13.12
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Structures
Swiss-model
Domains
InterPro
Nestin neuronal stem cell intermediate filament protein
Identifiers
Symbol
NES
NCBI gene
10763
HGNC
7756
OMIM
600915
RefSeq
NP_006608
UniProt
P48681
Other data
Locus
Chr. 1 q23.1
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Structures
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Neurofilaments (NF) are classed as type IV intermediate filaments found in the cytoplasm of neurons. They are protein polymers measuring 10 nm in diameter and many micrometers in length.[1] Together with microtubules (~25 nm) and microfilaments (7 nm), they form the neuronal cytoskeleton. They are believed to function primarily to provide structural support for axons and to regulate axon diameter, which influences nerve conduction velocity. The proteins that form neurofilaments are members of the intermediate filament protein family, which is divided into six types based on their gene organization and protein structure. Types I and II are the keratins which are expressed in epithelia. Type III contains the proteins vimentin, desmin, peripherin and glial fibrillary acidic protein (GFAP). Type IV consists of the neurofilament proteins NF-L, NF-M, NF-H and α-internexin. Type V consists of the nuclear lamins, and type VI consists of the protein nestin. The type IV intermediate filament genes all share two unique introns not found in other intermediate filament gene sequences, suggesting a common evolutionary origin from one primitive type IV gene.
Any proteinaceous filament that extends in the cytoplasm of a nerve cell is also termed a neurofibril.[2] This name is used in the neurofibrillary tangles of some neurodegenerative diseases.
^Yuan, A; Rao, MV; Veeranna; Nixon, RA (15 July 2012). "Neurofilaments at a glance". Journal of Cell Science. 125 (Pt 14): 3257–63. doi:10.1242/jcs.104729. PMC 3516374. PMID 22956720.
^"Definition of Neurofibril". www.merriam-webster.com. Retrieved 6 December 2019.
Neurofilaments (NF) are classed as type IV intermediate filaments found in the cytoplasm of neurons. They are protein polymers measuring 10 nm in diameter...
Neurofilament light polypeptide, also known as neurofilament light chain, abbreviated to NF-L or Nfl and with the HGNC name NEFL is a member of the intermediate...
of biomarkers, namely one called neurofilament light chain (NFL), in patients with Alzheimer's disease. Neurofilament light chain is a protein that is...
Neurofilament medium polypeptide (NF-M) is a protein that in humans is encoded by the NEFM gene. Neurofilaments are type IV intermediate filament heteropolymers...
on degeneration. Another class of antibody to neurofilament NF-L was shown to bind only neurofilaments in healthy neurons and their processes but failed...
PMID 9846894 – via EuropeMC. M, Sjögren; E, Englund (2004). "Negative neurofilament light and tau immunostaining in frontotemporal dementia". Dementia and...
neuroimaging afterwards. Further, levels of the neuroaxonal damage biomarker neurofilament light chain are elevated in blood plasma after TAVI. Whereas clinical...
antibody to MAP2 (green), Neurofilament NF-H (red) and DNA (blue). MAP2 is found in neuronal dendrites, while the neurofilament is found predominantly in...
7) after incubation overnight in NGF growth medium stained with anti-neurofilament antibody. Neurites growing out of the ganglion are visible. A spinal...
of brain damage. The Gothenburg study analyzed temporary levels of neurofilament light in cerebral spinal fluid which they conclude is evidence of damage...
alpha-synuclein associated with other proteins, such as ubiquitin, neurofilament protein, and alpha B crystallin. Tau proteins may also be present, and...
neurons, the roles of proteins showing loss of nerve tissue such as neurofilaments, tau, and N-acetylaspartate are under investigation. Improvement in...
stage of day 7) after incubation overnight in NGF growth medium stained with anti-neurofilament antibody. Note the axons growing out of the ganglion....
copurifies with other neurofilament subunits, as it was originally discovered, however in some mature neurons it can be the only neurofilament expressed. The...
mRNA expression of glial cell line-derived neurotrophic factor and neurofilament H in the hippocampus of the adult mouse brain". Biosci. Biotechnol....
Carleton (1985). "Hypothesis: interference with axonal transport of neurofilament as a common pathogenetic mechanism in certain diseases of the central...
towards a slowing of progression, as well as a significant reduction in neurofilament light chain, a putative ALS biomarker thought to indicate neuronal damage...
neuron is supported by a complex mesh of structural proteins called neurofilaments, which together with neurotubules (neuronal microtubules) are assembled...
for chromogranin, synaptophysin, neuron specific enolase, serotonin, neurofilament and Neural cell adhesion molecule; they are S-100 protein negative....
Neurofilament, heavy polypeptide (NEFH) is a protein that in humans is encoded by the NEFH gene. It is the gene for a heavy protein subunit that is combined...
In trials the drug was found to lower levels of an ALS biomarker, neurofilament light change, and in long-term trial extensions to slow disease. Under...
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