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Tropomyosin
PDB: 1C1G
Identifiers
Symbol
Tropomyosin
Pfam
PF00261
InterPro
IPR000533
PROSITE
PDOC00290
SCOP2
2tma / SCOPe / SUPFAM
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Tropomyosin is a two-stranded alpha-helical, coiled coil protein found in many animal and fungal cells. In animals, it is an important component of the muscular system which works in conjunction with troponin to regulate muscle contraction. It is present in smooth and striated muscle tissues, which can be found in various organs and body systems, including the heart, blood vessels, respiratory system, and digestive system. In fungi, tropomyosin is found in cell walls and helps maintain the structural integrity of cells.
Tropomyosin is found in other eukaryotes too, but not in plants. Overall, tropomyosin is an important protein that plays a vital role in the proper functioning of many different organisms.
Tropomyosin is a two-stranded alpha-helical, coiled coil protein found in many animal and fungal cells. In animals, it is an important component of the...
Tropomyosin alpha-3 chain is a protein that in humans is encoded by the TPM3 gene. This gene encodes a member of the tropomyosin family of actin-binding...
In enzymology, a tropomyosin kinase (EC 2.7.11.28) is an enzyme that catalyzes the chemical reaction ATP + tropomyosin ⇌ {\displaystyle \rightleftharpoons...
attached to the protein tropomyosin and lies within the groove between actin filaments in muscle tissue. In a relaxed muscle, tropomyosin blocks the attachment...
Tropomyosin receptor kinase A (TrkA), also known as high affinity nerve growth factor receptor, neurotrophic tyrosine kinase receptor type 1, or TRK1-transforming...
The protein tropomyosin covers the myosin-binding sites of the actin molecules in the muscle cell. For a muscle cell to contract, tropomyosin must be moved...
'track') stands for tropomyosin receptor kinase or tyrosine receptor kinase (and not "tyrosine kinase receptor" nor "tropomyosin-related kinase", as has...
create the distinctive striped appearance of skeletal muscle tissue. Tropomyosin, a protein, shields the myosin-binding sites, hindering actin from binding...
Tropomyosin alpha-1 chain is a protein that in humans is encoded by the TPM1 gene. This gene is a member of the tropomyosin (Tm) family of highly conserved...
complex, where it binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place. Troponin I prevents myosin from binding to actin in...
β-Tropomyosin, also known as tropomyosin beta chain is a protein that in humans is encoded by the TPM2 gene. β-tropomyosin is striated muscle-specific...
NGF can drive the expression of genes such as bcl-2 by binding to the Tropomyosin receptor kinase A, which stimulates the proliferation and survival of...
60 molecules of tropomyosin, the protein that blocks the active sites of the thin filaments when the muscle is relaxed. Each tropomyosin molecule has a...
Tropomyosin receptor kinase B (TrkB), also known as tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase,...
results in the movement of troponin and tropomyosin on thin filaments. The movement of troponin and tropomyosin is key in facilitating the myosin head...
outcomes are mainly due to the protein tropomyosin causing an IgE mediated immune system response. Tropomyosin, the major allergen in shellfish allergy...
{\text{Ca}}^{2+}} -calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase...
coughing or wheezing Tropomyosin, a minor allergen in dust mites, is also responsible for shellfish allergy. Exposure to inhaled tropomyosins from dust mites...
binding site. The remainder of the actin binding site is blocked by tropomyosin. With the ATP hydrolyzed, the cocked myosin head now contains adenosine...
it binds to the troponin of thin filaments, which causes the troponin-tropomyosin complex to change shape and allow the myosin heads to bind to the active...
development and severity; they are estimated to contribute to 60-90% of cases. Tropomyosin, the major allergen in dust mites, is also responsible for shellfish...
found to act as a potent and selective small-molecule agonist of the tropomyosin receptor kinase B (TrkB) (Kd ≈ 320 nM), the main signaling receptor of...
other muscle proteins present are two regulatory proteins, troponin and tropomyosin. Muscle tissue varies with function and location in the body. In vertebrates...
Ca2+ ions cause troponin to change shape; this moves the troponin + tropomyosin complex away, leaving the myosin binding sites open. The myosin head...
such a large range of functions is regulated through the binding of tropomyosin along the filaments. A cell's ability to dynamically form microfilaments...
calamari can occur. As with other molluscs, the allergen is probably tropomyosin. Chinese-style fried baby squid Japanese Ikameshi Japanese Ika Sōmen...
protein that in humans is encoded by the TNNT2 gene. Cardiac TnT is the tropomyosin-binding subunit of the troponin complex, which is located on the thin...
isoforms distinguished by mutually exclusive exon selection in alpha-tropomyosin. Lodish H, Berk A, Matsudaira P, Kaiser CA, Krieger M, Scott MP, Zipursky...
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