negative regulation of natural killer cell differentiation involved in immune response
negative regulation of interferon-gamma production
innate immune response
defense response to bacterium
detection of bacterium
defense response to Gram-positive bacterium
peptidoglycan catabolic process
pattern recognition receptor signaling pathway
antimicrobial humoral response
positive regulation of cytolysis in other organism
antimicrobial humoral immune response mediated by antimicrobial peptide
killing of cells of other organism
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
114771
242100
Ensembl
ENSG00000159527
ENSMUSG00000042244
UniProt
Q96LB9
A1A547
RefSeq (mRNA)
NM_052891
NM_207247
RefSeq (protein)
NP_443123
NP_997130
Location (UCSC)
Chr 1: 153.3 – 153.31 Mb
Chr 3: 91.92 – 91.94 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Location of human PGLYRP3 gene on chromosome 1 and schematic gene, cDNA, and protein structures with exons, introns, and protein domains indicated.
Peptidoglycan recognition protein 3 (PGLYRP3, formerly PGRP-Iα) is an antibacterial and anti-inflammatory innate immunity protein that in humans is encoded by the PGLYRP3 gene.[5][6][7][8]
^ abcGRCh38: Ensembl release 89: ENSG00000159527 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000042244 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Liu C, Xu Z, Gupta D, Dziarski R (September 2001). "Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules". The Journal of Biological Chemistry. 276 (37): 34686–94. doi:10.1074/jbc.M105566200. PMID 11461926. S2CID 44619852.
^Cite error: The named reference :2 was invoked but never defined (see the help page).
Peptidoglycanrecognitionprotein3 (PGLYRP3, formerly PGRP-Iα) is an antibacterial and anti-inflammatory innate immunity protein that in humans is encoded...
Peptidoglycanrecognitionproteins (PGRPs) are a group of highly conserved pattern recognition receptors with at least one peptidoglycanrecognition domain...
Peptidoglycanrecognitionprotein 1, PGLYRP1, also known as TAG7, is an antibacterial and pro-inflammatory innate immunity protein that in humans is encoded...
Peptidoglycanrecognitionprotein 4 (PGLYRP4, formerly PGRP-Iβ) is an antibacterial and anti-inflammatory innate immunity protein that in humans is encoded...
mammals. Mammals produce four secreted soluble peptidoglycanrecognitionproteins (PGLYRP-1, PGLYRP-2, PGLYRP-3 and PGLYRP-4) that recognize muramyl pentapeptide...
amyloid and C-reactive protein, lipid transferases, peptidoglycanrecognitionproteins (PGRPs) and the LRR, XA21D are all secreted proteins. One very important...
on innate immunity and bacterial peptidoglycan, for discovering the family of human peptidoglycanrecognitionproteins, which comprises PGLYRP1, PGLYRP2...
Glycoproteins are proteins which contain oligosaccharide chains covalently attached to amino acid side-chains. The carbohydrate is attached to the protein in a cotranslational...
outer membrane proteins and corresponding domains on the thin peptidoglycan layer. The Treponema repeat family of proteins (Tpr) are proteins expressed during...
domain containing 3 (NLRP3) (previously known as NACHT, LRR, and PYD domains-containing protein3 [NALP3] and cryopyrin), is a protein that in humans is...
toxicity problems than those targeting components of the cell wall (peptidoglycan or β-glucans) or 70S ribosome, structures which are absent in human...
signals produced by Gram-negative bacteria. Peptidoglycanrecognitionproteins (PGRPs) sense DAP-type peptidoglycan, which activates the Imd signalling cascade...
peptidoglycan, from their own cell walls into the epithelial cells. The injected peptidoglycan is recognized by the cytoplasmic pattern recognition receptor...
acts as a pyrogen and as a stimulant of slow-wave sleep. Peptidoglycanrecognitionprotein 4 (PGLYRP4), in mammals (mice), interacts with TCT and reduces...
periplasmic lipoprotein beta-lactamases BRO-1 and BRO-2, which protect the peptidoglycan layer by hydrolyzing the beta-lactam molecules that enter the bacterial...
for prey using its pili, it burrows through the host outer membrane/ peptidoglycan cell wall and enters the periplasmic space. The Bdellovibrio bacterium...
layer and protected by a multilayer rigid coat composed of peptidoglycan and a variety of proteins. Endospores show no detectable metabolism and can survive...
composed of peptidoglycan (amino acids and sugars). Some eukaryotic cells also have cell walls, but none that are made of peptidoglycan. The outer membrane...
component of bacterial peptidoglycan, a recognition structure or activator for nucleotide-binding oligomerization domain 2 (NOD2) protein. It is a constituent...
glutamate for proper metabolic functions. Protein A Protein A is anchored to staphylococcal peptidoglycan pentaglycine bridges (chains of five glycine...
recognizes bacterial molecules (peptidoglycans) and stimulates an immune reaction. NOD2 is an intracellular pattern recognition receptor, which is similar...
molecular patterns, such as such as peptidoglycan, which is found on some bacterial cells. It is thought that NLRP proteins sense danger signals linked to...
capable of carrying out photosynthesis. Cyanobacteria also contain a peptidoglycan cell wall, which is thicker than in other gram-negative bacteria, and...
Global Information
