NLR family pyrin domain containing 3 (NLRP3) (previously known as NACHT, LRR, and PYD domains-containing protein 3 [NALP3] and cryopyrin), is a protein that in humans is encoded by the NLRP3 gene[5] located on the long arm of chromosome 1.[6]
NLRP3 is expressed predominantly in macrophages and as a component of the inflammasome,[7][8]: 436 detects products of damaged cells such as extracellular ATP and crystalline uric acid. Activated NLRP3 in turn triggers an immune response. Mutations in the NLRP3 gene are associated with a number of organ specific autoimmune diseases.
^ abcGRCh38: Ensembl release 89: ENSG00000162711 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000032691 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Anon. (2015). "Entrez Gene: NLRP3 NLR family, pyrin domain containing 3 [Homo sapiens (human)], Gene ID: 114548 (updated on 13-Nov-2015)". Bethesda, MD, USA: National Center for Biotechnology Information, National Library of Medicine. Retrieved 13 November 2015.
^Hoffman HM, Wright FA, Broide DH, et al. (May 2000). "Identification of a locus on chromosome 1q44 for familial cold urticaria". American Journal of Human Genetics. 66 (5): 1693–8. doi:10.1086/302874. PMC 1378006. PMID 10741953.
^Tao JH, Zhang Y, Li XP (Dec 2013). "P2X7R: a potential key regulator of acute gouty arthritis". review. Seminars in Arthritis and Rheumatism. 43 (3): 376–80. doi:10.1016/j.semarthrit.2013.04.007. PMID 23786870.
^Lu A, Wu H (Feb 2015). "Structural mechanisms of inflammasome assembly". review. The FEBS Journal. 282 (3): 435–44. doi:10.1111/febs.13133. PMC 6400279. PMID 25354325.
NLR family pyrin domain containing 3 (NLRP3) (previously known as NACHT, LRR, and PYD domains-containing protein 3 [NALP3] and cryopyrin), is a protein...
which includes seven NLRP3 molecules. NLRP3 has been recognized as the largest inflammasome, with a diameter of around 2 um. NLRP3 oligomerization is activated...
Dapansutrile (OLT1177) is an inhibitor of the NLRP3 (nucleotide-binding domain leucine-rich repeat and pyrin domain containing receptor 3) inflammasome...
NLRC4 can recognise flagellin and type III secretion system components. NLRP3 is activated by cellular events induced by different PAMPs and DAMPs stimuli...
and activate proinflammatory process and production of IL-1β and IL-18. NLRP3 (contains three domain: pyrin domain, a nucleotide-binding domain and a...
response to aluminum in adjuvants. NLRP3 is involved in the immune response to toxins in the environment. For example, NLRP3 is activated to form an inflammasome...
would acquire Jecure Therapeutics, gaining access to Jecure's portfolio of NLRP3 inhibitors developed to fight inflammatory diseases like non-alcoholic steatohepatitis...
reactions. The NLRP3-containing inflammasome forms in response to danger signals (e.g., LPS, pathogens, etc.). These signals cause cytosolic NLRP3 (i.e., NLR...
experimentally to inhibit release of interleukin 1 beta from the NALP3 (or NLRP3) inflammasome. Sulfonylureas – as opposed to metformin, the thiazolidinediones...
Leucine Rich Repeat NLRP3 will sense an efflux of potassium ions from the cell. This cellular ion imbalance leads to oligomerisation of NLRP3 molecules to form...
(called NLRP1 to NLRP14). NLRP3 and NLRP4 are responsible for the inflammasome activation. NLRP3 can be activated and give rise to NLRP3 inflammasome by ATP...
cryopyrin-associated periodic syndromes (CAPS) caused by mutations in the CIAS1/NALP3 (aka NLRP3) gene at location 1q44. The effect of FCAS on the quality of life of patients...
reaction in macrophages, which is initiated by the NLRP3 inflammasome protein complex. Activation of the NLRP3 inflammasome recruits the enzyme caspase 1, which...
clinically relevant periods. Silica crystals inside the lungs can activate the NLRP3 inflammasome inside macrophages and dendritic cells and thereby result in...
Cholesterol crystals are believed to induce inflammation by activation of the NLRP3 inflammasome. In addition to being a source of inflammation, cholesterol...
Stress by regulating oxidative stress and inflammation associated with the NLRP3 gene. Maianthemum Search for "Polygonatum", World Checklist of Selected...
against thioacetamide-induced hepatic damage in Wistar rat: investigation on NLRP3, MMP-2, and stellate cell activation". Naunyn-Schmiedeberg's Archives of...
against thioacetamide-induced hepatic damage in Wistar rat: investigation on NLRP3, MMP-2, and stellate cell activation". Naunyn-Schmiedeberg's Archives of...
suggests that DHM protects against DOX-induced cardiotoxicity by inhibiting NLRP3 inflammasome activation via stimulation of the SIRT1 pathway. In a trial...
is highly activated in patients with Parkinson's disease by NLRP3 inflammasome. The NLRP3 inflammasome reacts to synuclein containing protein clumps by...