positive regulation of stress-activated MAPK cascade
positive regulation of Notch signaling pathway
positive regulation of transcription by RNA polymerase II
cellular response to organic cyclic compound
positive regulation of cell population proliferation
innate immune response
response to nutrient
positive regulation of dendritic cell cytokine production
positive regulation of protein K63-linked ubiquitination
cellular response to peptidoglycan
positive regulation of MAP kinase activity
interleukin-1-mediated signaling pathway
cellular response to lipopolysaccharide
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
64127
257632
Ensembl
ENSG00000167207
ENSMUSG00000055994
UniProt
Q9HC29
Q80SY9
RefSeq (mRNA)
NM_001293557 NM_022162 NM_001370466
NM_145857
RefSeq (protein)
NP_001280486 NP_071445 NP_001357395
NP_665856
Location (UCSC)
Chr 16: 50.69 – 50.73 Mb
Chr 8: 89.37 – 89.42 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2), also known as caspase recruitment domain-containing protein 15 (CARD15) or inflammatory bowel disease protein 1 (IBD1), is a protein that in humans is encoded by the NOD2 gene located on chromosome 16.[5][6] NOD2 plays an important role in the immune system. It recognizes bacterial molecules (peptidoglycans) and stimulates an immune reaction.[7]
NOD2 is an intracellular pattern recognition receptor, which is similar in structure to resistant proteins of plants and recognizes molecules containing the specific structure called muramyl dipeptide (MDP) that is found in certain bacteria.[8]
^ abcGRCh38: Ensembl release 89: ENSG00000167207 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000055994 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Gilberts EC, Greenstein AJ, Katsel P, Harpaz N, Greenstein RJ (Dec 1994). "Molecular evidence for two forms of Crohn disease". Proceedings of the National Academy of Sciences of the United States of America. 91 (26): 12721–4. Bibcode:1994PNAS...9112721G. doi:10.1073/pnas.91.26.12721. PMC 45511. PMID 7809109.
^Hugot JP, Laurent-Puig P, Gower-Rousseau C, Olson JM, Lee JC, Beaugerie L, Naom I, Dupas JL, Van Gossum A, Orholm M, Bonaiti-Pellie C, Weissenbach J, Mathew CG, Lennard-Jones JE, Cortot A, Colombel JF, Thomas G (Feb 1996). "Mapping of a susceptibility locus for Crohn's disease on chromosome 16". Nature. 379 (6568): 821–3. Bibcode:1996Natur.379..821H. doi:10.1038/379821a0. PMID 8587604. S2CID 4311407.
^Mahla RS, Reddy MC, Prasad DV, Kumar H (September 2013). "Sweeten PAMPs: Role of Sugar Complexed PAMPs in Innate Immunity and Vaccine Biology". Frontiers in Immunology. 4: 248. doi:10.3389/fimmu.2013.00248. PMC 3759294. PMID 24032031.
^Kufer TA, Banks DJ, Philpott DJ (Aug 2006). "Innate immune sensing of microbes by Nod proteins". Annals of the New York Academy of Sciences. 1072 (1): 19–27. Bibcode:2006NYASA1072...19K. doi:10.1196/annals.1326.020. PMID 17057187. S2CID 20217610.
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2), also known as caspase recruitment domain-containing protein 15 (CARD15) or inflammatory...
inflammation-induced tissue damage in response to NOD2 ligands (see below), as these muropeptides can no longer be recognized by NOD2 upon separation of the peptide component...
and NOD2 signaling and therefore, limiting inflammation caused by NOD1, NOD2 signaling pathways. Another possibility is to remove the sensor for NOD2, which...
Yao syndrome (YAOS) (formerly called NOD2-associated autoinflammatory disease) is an autoinflammatory syndrome involving episodes of fever and abnormal...
which affects the skin, eyes, and joints. It is caused by a mutation in the NOD2 (CARD15) gene. Symptoms usually begin before the age of four, and the disease...
structure or activator for nucleotide-binding oligomerization domain 2 (NOD2) protein. It is a constituent of both Gram-positive and Gram-negative bacteria...
molecules Nucleotide-binding oligomerization domain-containing protein 2 (NOD2), another receptor protein that recognizes foreign molecules Nod (gesture)...
de Groot CJ, Bertina RM, Pasterkamp G (April 2008). "Maternal TLR4 and NOD2 gene variants, pro-inflammatory phenotype and susceptibility to early-onset...
activating the non-classical autophagy pathway, dependent on Atg16L1 and NOD2 genes. B. thetaiotaomicron induces the differentiation of T regulatory cells...
Andersen PS, Girardin SE (February 2007). "Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1beta generation". Clinical and Experimental Immunology...
involving pattern recognition receptors and intracellular pathogen sensors NOD2 and CARD8. Their activation leads to regulation of caspase-1 and NF-kappa-B...
into Crohn's disease confirms that it is identified with mutation of the NOD2 gene. June 1 Crown Prince Dipendra of Nepal kills his father, the king, his...
inflammasomes. Also, non-inflammasome-forming PRRs such as TLRs, NOD1 and NOD2 also play important roles in pyroptosis. These receptors upregulate expression...
interactions with cells of the intestinal mucosa: Toll-like receptors and NOD2". Gut. 54 (8): 1182–93. doi:10.1136/gut.2004.062794. PMC 1774880. PMID 15840688...
many of which are frameshift. Crohn's disease has an association with the NOD2 gene. The mutation is an insertion of a Cytosine at position 3020. This leads...
antibodies (ASCA) in Crohn's disease are associated with disease severity but not NOD2/CARD15 mutations". Clin. Exp. Immunol. 135 (3): 490–96. doi:10.1111/j.1365-2249...
may be linked to variants in six immunity-related genes: SLC11A1, PRKN, NOD2, ATG16L1, iNOS, and IFNG, as well as in two long non-coding RNAs. A genome-wide...
form) Congenital insensitivity to pain with anhidrosis Crohn's disease (the NOD2/CARD15 locus appears to be implicated) Joubert syndrome type 2 is disproportionately...
effects as natural MDP with the advantage of a longer half-life in plasma. NOD2 is a pattern recognition receptor which is found in several kinds of white...
a member of NOD-like receptor protein family and is a close relative of NOD2. NOD1 is an intracellular pattern recognition receptor, which is similar...
(April 5, 2003). "TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells". Gastroenterology. 124...
leucine-rich repeat (LRR) motif similar to TLRs. Some of these molecules like NOD2 interact with RIP2 kinase that activates NF-κB signaling, whereas others...
ATG16L1 recruiting by NOD1 and NOD2. This results in autophagy in RIP2/NF-κB independent manner. It is also known that NOD2 interacts with ATG16L, ATG5 and...
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