Passive antibody therapy, also called serum therapy, is a subtype of passive immunotherapy that administers antibodies (same as immunoglobin) to target and kill pathogens or cancer cells.[1] It is designed to draw support from foreign antibodies that are donated from a person, extracted from animals, or made in the laboratory to elicit an immune response instead of relying on the innate immune system to fight disease. It has a long history from the 18th century for treating infectious diseases and is now a common cancer treatment. The mechanism of actions include: antagonistic and agonistic reaction, complement-dependent cytotoxicity (CDC), and antibody-dependent cellular cytotoxicity (ADCC).
^Slifka, Mark K.; Amanna, Ian J. (2018). "Passive Immunization". Plotkin's Vaccines: 84–95.e10. doi:10.1016/B978-0-323-35761-6.00008-0. ISBN 9780323357616. PMC 7151993.
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Passiveantibodytherapy, also called serum therapy, is a subtype of passive immunotherapy that administers antibodies (same as immunoglobin) to target...
from these antibodies may occur because of long-lasting response to antigens. Passive monoclonal antibodytherapy can ensure consistent antibody concentration...
through blood products that contain antibodies, such as in immunoglobulin therapy or antiserum therapy. Passive immunization is used when there is a...
immune system to fight cancer), CAR-T cells, and targeted antibodytherapies. In contrast, passive immunotherapy does not directly target tumor cells, but...
antiserum is a blood serum containing antibodies (either monoclonal or polyclonal) that is used to spread passive immunity to many diseases via blood donation...
of antibodies is provided by passive immunization from the mother. Early endogenous antibody production varies for different kinds of antibodies, and...
Immunoglobulin therapy is the use of a mixture of antibodies (normal human immunoglobulin or NHIG) to treat several health conditions. These conditions...
the antibody to bind to its target antigen. Chimeric antibody names contain a -xi- stem. Examples of chimeric antibodies approved for human therapy include...
components Organ transplantation and tissue transplants Stem-cell therapyAntibodies for passive immunity (e.g., to treat a virus infection) Human reproductive...
potentially be used to develop passiveantibodytherapy against influenza virus transmission. The ability of an antiviral antibody to inhibit hemagglutination...
Polyclonal antibodies (pAbs) are antibodies that are secreted by different B cell lineages within the body (whereas monoclonal antibodies come from a single...
palivizumab or nirsevimab (both are monoclonal antibody treatments) can prevent RSV infection in high-risk infants. Passive immunization is available to prevent...
infectious disease. This plasma contains antibodies specific to a pathogen and can be used therapeutically by providing passive immunity when transfusing it to...
An antitoxin is an antibody with the ability to neutralize a specific toxin. Antitoxins are produced by certain animals, plants, and bacteria in response...
therapeutic antibodies and the pharmacological mechanisms of anti-IgE therapy have been summarized in articles by the inventor of the anti-IgE therapy.[non-primary...
because the antibodies are naturally broken down, and if there are no B cells to produce more antibodies, they will disappear. Passive immunization occurs...
against the tumor antigen NGcGM3. Therefore, rather than being a passiveantibodytherapy, Racotumomab acts as a therapeutic vaccine. In melanoma, breast...
newborn farm animals. They receive no passive transfer of immunity via the placenta before birth, so any antibodies that they need have to be ingested (unless...
a biopharmaceutical company, is developing a monoclonal antibody as a prophylactic therapy to prevent clinical signs of parvovirus infection and also...
stimulation, while immunotherapies that administer antibodies directly to the system are classified as passive immunotherapies. Active immunotherapies can elicit...
use of drugs (whether chemotherapy, hormonal therapy or targeted therapy) constitutes systemic therapy for cancer in that they are introduced into the...
drug delivery: active targeted drug delivery, such as some antibody medications, and passive targeted drug delivery, such as the enhanced permeability...