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Passive antibody therapy information


Passive antibody therapy, also called serum therapy, is a subtype of passive immunotherapy that administers antibodies (same as immunoglobin) to target and kill pathogens or cancer cells.[1] It is designed to draw support from foreign antibodies that are donated from a person, extracted from animals, or made in the laboratory to elicit an immune response instead of relying on the innate immune system to fight disease. It has a long history from the 18th century for treating infectious diseases and is now a common cancer treatment. The mechanism of actions include: antagonistic and agonistic reaction, complement-dependent cytotoxicity (CDC), and antibody-dependent cellular cytotoxicity (ADCC).

  1. ^ Slifka, Mark K.; Amanna, Ian J. (2018). "Passive Immunization". Plotkin's Vaccines: 84–95.e10. doi:10.1016/B978-0-323-35761-6.00008-0. ISBN 9780323357616. PMC 7151993.

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Passive antibody therapy

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Passive antibody therapy, also called serum therapy, is a subtype of passive immunotherapy that administers antibodies (same as immunoglobin) to target...

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Monoclonal antibody therapy

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from these antibodies may occur because of long-lasting response to antigens. Passive monoclonal antibody therapy can ensure consistent antibody concentration...

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Passive immunity

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through blood products that contain antibodies, such as in immunoglobulin therapy or antiserum therapy. Passive immunization is used when there is a...

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Cancer immunotherapy

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immune system to fight cancer), CAR-T cells, and targeted antibody therapies. In contrast, passive immunotherapy does not directly target tumor cells, but...

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Neutralizing antibody

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Casadevall, A; Dadachova, E; Pirofski, LA (September 2004). "Passive antibody therapy for infectious diseases". Nature Reviews. Microbiology. 2 (9):...

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Antiserum

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antiserum is a blood serum containing antibodies (either monoclonal or polyclonal) that is used to spread passive immunity to many diseases via blood donation...

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Antibody

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of antibodies is provided by passive immunization from the mother. Early endogenous antibody production varies for different kinds of antibodies, and...

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Immunoglobulin therapy

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Immunoglobulin therapy is the use of a mixture of antibodies (normal human immunoglobulin or NHIG) to treat several health conditions. These conditions...

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Humanized antibody

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the antibody to bind to its target antigen. Chimeric antibody names contain a -xi- stem. Examples of chimeric antibodies approved for human therapy include...

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Biopharmaceutical

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components Organ transplantation and tissue transplants Stem-cell therapy Antibodies for passive immunity (e.g., to treat a virus infection) Human reproductive...

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Antigenic variation

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potentially be used to develop passive antibody therapy against influenza virus transmission. The ability of an antiviral antibody to inhibit hemagglutination...

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Polyclonal antibodies

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Polyclonal antibodies (pAbs) are antibodies that are secreted by different B cell lineages within the body (whereas monoclonal antibodies come from a single...

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Respiratory syncytial virus

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palivizumab or nirsevimab (both are monoclonal antibody treatments) can prevent RSV infection in high-risk infants. Passive immunization is available to prevent...

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Convalescent plasma

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infectious disease. This plasma contains antibodies specific to a pathogen and can be used therapeutically by providing passive immunity when transfusing it to...

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Index of oncology articles

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2IT-BAD monoclonal antibody 170 – 3-aminopyridine-2-carboxaldehyde thiosemicarbazone – 3-AP – 3-dimensional conformal radiation therapy – 3-dimensional radiation...

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Antitoxin

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An antitoxin is an antibody with the ability to neutralize a specific toxin. Antitoxins are produced by certain animals, plants, and bacteria in response...

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Omalizumab

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therapeutic antibodies and the pharmacological mechanisms of anti-IgE therapy have been summarized in articles by the inventor of the anti-IgE therapy.[non-primary...

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Immunization

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because the antibodies are naturally broken down, and if there are no B cells to produce more antibodies, they will disappear. Passive immunization occurs...

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Racotumomab

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against the tumor antigen NGcGM3. Therefore, rather than being a passive antibody therapy, Racotumomab acts as a therapeutic vaccine. In melanoma, breast...

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Colostrum

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newborn farm animals. They receive no passive transfer of immunity via the placenta before birth, so any antibodies that they need have to be ingested (unless...

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Canine parvovirus

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a biopharmaceutical company, is developing a monoclonal antibody as a prophylactic therapy to prevent clinical signs of parvovirus infection and also...

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Active immunotherapy

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stimulation, while immunotherapies that administer antibodies directly to the system are classified as passive immunotherapies. Active immunotherapies can elicit...

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Microantibody

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PW (September 2004). "Therapeutic antibody gene transfer: an active approach to passive immunity". Molecular Therapy. 10 (3): 411–6. doi:10.1016/j.ymthe...

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Chemotherapy

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use of drugs (whether chemotherapy, hormonal therapy or targeted therapy) constitutes systemic therapy for cancer in that they are introduced into the...

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Targeted drug delivery

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drug delivery: active targeted drug delivery, such as some antibody medications, and passive targeted drug delivery, such as the enhanced permeability...

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