Targeted drug delivery, sometimes called smart drug delivery,[1] is a method of delivering medication to a patient in a manner that increases the concentration of the medication in some parts of the body relative to others. This means of delivery is largely founded on nanomedicine, which plans to employ nanoparticle-mediated drug delivery in order to combat the downfalls of conventional drug delivery. These nanoparticles would be loaded with drugs and targeted to specific parts of the body where there is solely diseased tissue, thereby avoiding interaction with healthy tissue. The goal of a targeted drug delivery system is to prolong, localize, target and have a protected drug interaction with the diseased tissue. The conventional drug delivery system is the absorption of the drug across a biological membrane, whereas the targeted release system releases the drug in a dosage form. The advantages to the targeted release system is the reduction in the frequency of the dosages taken by the patient, having a more uniform effect of the drug, reduction of drug side-effects, and reduced fluctuation in circulating drug levels. The disadvantage of the system is high cost, which makes productivity more difficult, and the reduced ability to adjust the dosages.
Targeted drug delivery systems have been developed to optimize regenerative techniques. The system is based on a method that delivers a certain amount of a therapeutic agent for a prolonged period of time to a targeted diseased area within the body. This helps maintain the required plasma and tissue drug levels in the body, thereby preventing any damage to the healthy tissue via the drug. The drug delivery system is highly integrated and requires various disciplines, such as chemists, biologists, and engineers, to join forces to optimize this system.[2]
^Muller, R; Keck, C (2004). "Challenges and solutions for the delivery of biotech drugs – a review of drug nanocrystal technology and lipid nanoparticles". Journal of Biotechnology. 113 (1–3): 151–170. doi:10.1016/j.jbiotec.2004.06.007. PMID 15380654.
^Saltzman, W. Mark; Torchilin, Vladimir P. (2008). "Drug delivery systems". AccessScience. McGraw-Hill Companies. doi:10.1036/1097-8542.757275.
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Targeteddrugdelivery, sometimes called smart drugdelivery, is a method of delivering medication to a patient in a manner that increases the concentration...
nanotechnology in drugdelivery is still a promising area for future research. Targeteddrugdelivery is the delivery of a drug to its target site without...
Nanoparticle drugdelivery systems are engineered technologies that use nanoparticles for the targeteddelivery and controlled release of therapeutic agents...
precision. Targeteddrugdelivery systems facilitate the selective delivery of therapeutic agents to specific disease sites while minimizing off-target effects...
healthy cells, as in targeted therapy or targeteddrugdelivery This disambiguation page lists articles associated with the title Smart drug. If an internal...
substances. Nanocarriers are currently being studied for their use in drugdelivery and their unique characteristics demonstrate potential use in chemotherapy...
most known for her work on nanotechnology, primarily focusing on targeteddrugdelivery and electrochemistry for sensors. Mao completed her BSc in chemistry...
for treating cancer. Exosomes are nanocarriers that can provide targeteddrugdelivery of therapeutics to enhance local cytotoxic effects while minimizing...
of cancer. Antibody-mediated targeting of dendrimers to cell targets has also shown promise for targeteddrugdelivery. As epidermal growth factor receptors...
combined; antibody-drug conjugates combine biologic and cytotoxic mechanisms into one targeted therapy. Another form of targeted therapy involves the...
Immunoliposome therapy is a targeteddrugdelivery method that involves the use of liposomes (artificial lipid bilayer vesicles) coupled with monoclonal...
Selective organ targeting (SORT) is a novel approach in the field of targeteddrugdelivery that systematically engineers multiple classes of lipid nanoparticles...
and a biochemically active molecule. Aquasomes are utilized for targeteddrugdelivery to achieve specific therapeutic effects, and are biocompatible,...
administer vaccines, drugs, and other therapeutic agents. While microneedles were initially explored for transdermal drugdelivery applications, their...
incorporating cholesterol as an excipient. Niosomes are utilized for drugdelivery to specific sites to achieve desired therapeutic effects. Structurally...
pharmaceutical drugdelivery system (and part of nanoparticle drugdelivery), and a novel pharmaceutical formulation. LNPs as a drugdelivery vehicle were...
atoms. As gold nanoparticles (AuNPs) are further investigated for targeteddrugdelivery in humans, their toxicity needs to be considered. For the most part...
the bloodstream. An advantage of a transdermal drugdelivery route over other types of medication delivery (such as oral, topical, intravenous, or intramuscular)...
nanoparticle-based drugdelivery is a means in which magnetic particles such as iron oxide nanoparticles are a component of a delivery vehicle for magnetic drug delivery...
Additionally, targeteddrugdelivery reduces the side effect possessed by crude drug via minimizing undesired exposure to the healthy cells. Drugdelivery focuses...
drugdelivery is the delivery of medications directly into the bladder by urinary catheter. This method of drugdelivery is used to directly target diseases...
as tumor-targeted nanoparticles. Further, RGD is widely used in tissue engineering to promote tissue regeneration. Conventional drugdelivery methods,...
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