Convalescent plasma is the blood plasma collected from a survivor of an infectious disease. This plasma contains antibodies specific to a pathogen and can be used therapeutically by providing passive immunity when transfusing it to a newly infected patient with the same condition. Convalescent plasma can be transfused as it has been collected or become the source material for hyperimmune serum or anti-pathogen monoclonal antibodies; the latter consists exclusively of IgG, while convalescent plasma also includes IgA and IgM. Collection is typically achieved by apheresis, but in low-to-middle income countries, the treatment can be administered as convalescent whole blood.
Methods of convalescent plasma collection, processing, and administration. Plasma is typically collected using apheresis. After collection, convalescent plasma may then be aliquoted before being stored and used for treatment. Alternatively, convalescent plasma may be pooled across many different donors and processed to pharmaceutical-grade convalescent plasma. Pathogen reduction technologies, such as solvent/detergent treatment or light treatment with additives can be employed to inactivate potential pathogens, including viruses, bacteria, protozoa, and leukocytes contaminating the plasma. Fractionation techniques may be used to create hyperimmune products. CP, convalescent plasma; HS, hyperimmune serum; PGCP, pharmaceutical-grade convalescent plasma; pharmaceutical-grade convalescent plasma; PRT, pathogen reduction technologies; S/D, solvent/detergent.
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Convalescentplasma is the blood plasma collected from a survivor of an infectious disease. This plasma contains antibodies specific to a pathogen and...
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S.-H.; Chan, K.-H.; Lin, C.-K.; Yuen, K.-Y. (19 January 2011). "ConvalescentPlasma Treatment Reduced Mortality in Patients With Severe Pandemic Influenza...
criticizing his Emergency Use Authorizations of hydroxychloroquine, convalescentplasma, and remdesivir for COVID-19. Topol wrote, "These repeated breaches...
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P, Khaw FM, Lim WS, et al. (January 2015). "The effectiveness of convalescentplasma and hyperimmune immunoglobulin for the treatment of severe acute...
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