A neutralizing antibody (NAb) is an antibody that defends a cell from a pathogen or infectious particle by neutralizing any effect it has biologically. Neutralization renders the particle no longer infectious or pathogenic.[3][4]
Neutralizing antibodies are part of the humoral response of the adaptive immune system against viruses, intracellular bacteria and microbial toxin. By binding specifically to surface structures (antigen) on an infectious particle, neutralizing antibodies prevent the particle from interacting with its host cells it might infect and destroy.
^Mike Recher; Karl S Lang; Lukas Hunziker; Stefan Freigang; Bruno Eschli; Nicola L Harris; Alexander Navarini; Beatrice M Senn; Katja Fink; Marius Lötscher; Lars Hangartner; Raphaël Zellweger; Martin Hersberger; Alexandre Theocharides; Hans Hengartner; Rolf M Zinkernagel (8 August 2004). "Deliberate removal of T cell help improves virus-neutralizing antibody production". Nature Immunology. 5 (9): 934–942. doi:10.1038/ni1102. PMID 15300247. S2CID 1351951.
^Cite error: The named reference Stachowiak was invoked but never defined (see the help page).
^"Neutralizing antibody". Biology-Online. 2008. Retrieved 4 July 2009.
^Klasse, P. J. (9 September 2014). "Neutralization of Virus Infectivity by Antibodies: Old Problems in New Perspectives". Advances in Biology. 2014: 1–24. doi:10.1155/2014/157895. PMC 4835181. PMID 27099867.
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A neutralizingantibody (NAb) is an antibody that defends a cell from a pathogen or infectious particle by neutralizing any effect it has biologically...
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JT, Diamond MS, Kuhn RJ, Rossmann MG (March 2008). "Binding of a neutralizingantibody to dengue virus alters the arrangement of surface glycoproteins"...
Ligand Binding Efficiency of the HIV-1-neutralizingAntibodies Differ from Those of Antibodies That Cannot Neutralize HIV-1". The Journal of Biological Chemistry...
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N-terminus of the gp41 is also a potential target because it contains neutralizingantibody epitopes. N36 and C34, or NHR- and CHR-based peptides (or short...
the subset of antibodies that retain most of the activity is the one that drives viral neutralization, i.e. neutralizingantibodies, which can be quantified...
develop neutralizingantibodies against monoclonal antibodies. Neutralization occurs when an antidrug antibody prevents a monoclonal antibody such as...
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