Oxyprothepin decanoate, sold under the brand name Meclopin, is a typical antipsychotic which was used in the treatment of schizophrenia in the Czech Republic but is no longer marketed.[2] It is administered by depot injection into muscle.[2] The medication has an approximate duration of 2 to 3 weeks.[1] The history of oxyprothepin decanoate has been reviewed.[3]
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t
e
Pharmacokinetics of long-acting injectable antipsychotics
Medication
Brand name
Class
Vehicle
Dosage
Tmax
t1/2 single
t1/2 multiple
logPc
Ref
Aripiprazole lauroxil
Aristada
Atypical
Watera
441–1064 mg/4–8 weeks
24–35 days
?
54–57 days
7.9–10.0
Aripiprazole monohydrate
Abilify Maintena
Atypical
Watera
300–400 mg/4 weeks
7 days
?
30–47 days
4.9–5.2
Bromperidol decanoate
Impromen Decanoas
Typical
Sesame oil
40–300 mg/4 weeks
3–9 days
?
21–25 days
7.9
[4]
Clopentixol decanoate
Sordinol Depot
Typical
Viscoleob
50–600 mg/1–4 weeks
4–7 days
?
19 days
9.0
[5]
Flupentixol decanoate
Depixol
Typical
Viscoleob
10–200 mg/2–4 weeks
4–10 days
8 days
17 days
7.2–9.2
[5][6]
Fluphenazine decanoate
Prolixin Decanoate
Typical
Sesame oil
12.5–100 mg/2–5 weeks
1–2 days
1–10 days
14–100 days
7.2–9.0
[7][8][9]
Fluphenazine enanthate
Prolixin Enanthate
Typical
Sesame oil
12.5–100 mg/1–4 weeks
2–3 days
4 days
?
6.4–7.4
[8]
Fluspirilene
Imap, Redeptin
Typical
Watera
2–12 mg/1 week
1–8 days
7 days
?
5.2–5.8
[10]
Haloperidol decanoate
Haldol Decanoate
Typical
Sesame oil
20–400 mg/2–4 weeks
3–9 days
18–21 days
7.2–7.9
[11][12]
Olanzapine pamoate
Zyprexa Relprevv
Atypical
Watera
150–405 mg/2–4 weeks
7 days
?
30 days
–
Oxyprothepin decanoate
Meclopin
Typical
?
?
?
?
?
8.5–8.7
Paliperidone palmitate
Invega Sustenna
Atypical
Watera
39–819 mg/4–12 weeks
13–33 days
25–139 days
?
8.1–10.1
Perphenazine decanoate
Trilafon Dekanoat
Typical
Sesame oil
50–200 mg/2–4 weeks
?
?
27 days
8.9
Perphenazine enanthate
Trilafon Enanthate
Typical
Sesame oil
25–200 mg/2 weeks
2–3 days
?
4–7 days
6.4–7.2
[13]
Pipotiazine palmitate
Piportil Longum
Typical
Viscoleob
25–400 mg/4 weeks
9–10 days
?
14–21 days
8.5–11.6
[6]
Pipotiazine undecylenate
Piportil Medium
Typical
Sesame oil
100–200 mg/2 weeks
?
?
?
8.4
Risperidone
Risperdal Consta
Atypical
Microspheres
12.5–75 mg/2 weeks
21 days
?
3–6 days
–
Zuclopentixol acetate
Clopixol Acuphase
Typical
Viscoleob
50–200 mg/1–3 days
1–2 days
1–2 days
4.7–4.9
Zuclopentixol decanoate
Clopixol Depot
Typical
Viscoleob
50–800 mg/2–4 weeks
4–9 days
?
11–21 days
7.5–9.0
Note: All by intramuscular injection. Footnotes:a = Microcrystalline or nanocrystalline aqueous suspension. b = Low-viscosity vegetable oil (specifically fractionated coconut oil with medium-chain triglycerides). c = Predicted, from PubChem and DrugBank. Sources:Main: See template.
^ abRoss J. Baldessarini (1985). Chemotherapy in Psychiatry: Principles and Practice. Harvard University Press. pp. 36–. ISBN 978-0-674-11383-1.
^ abIndex Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 781–. ISBN 978-3-88763-075-1.
^De Risio A, Lang AP (February 2014). "History and therapeutic rationale of long acting antipsychotics". Curr Clin Pharmacol. 9 (1): 39–52. doi:10.2174/15748847113089990057. PMID 23343446.
^Parent M, Toussaint C, Gilson H (1983). "Long-term treatment of chronic psychotics with bromperidol decanoate: clinical and pharmacokinetic evaluation". Current Therapeutic Research. 34 (1): 1–6.
^ abJørgensen A, Overø KF (1980). "Clopenthixol and flupenthixol depot preparations in outpatient schizophrenics. III. Serum levels". Acta Psychiatrica Scandinavica. Supplementum. 279: 41–54. doi:10.1111/j.1600-0447.1980.tb07082.x. PMID 6931472.
^ abReynolds JE (1993). "Anxiolytic sedatives, hypnotics and neuroleptics.". Martindale: The Extra Pharmacopoeia (30th ed.). London: Pharmaceutical Press. pp. 364–623.
^Ereshefsky L, Saklad SR, Jann MW, Davis CM, Richards A, Seidel DR (May 1984). "Future of depot neuroleptic therapy: pharmacokinetic and pharmacodynamic approaches". The Journal of Clinical Psychiatry. 45 (5 Pt 2): 50–9. PMID 6143748.
^ abCurry SH, Whelpton R, de Schepper PJ, Vranckx S, Schiff AA (April 1979). "Kinetics of fluphenazine after fluphenazine dihydrochloride, enanthate and decanoate administration to man". British Journal of Clinical Pharmacology. 7 (4): 325–31. doi:10.1111/j.1365-2125.1979.tb00941.x. PMC 1429660. PMID 444352.
^Young D, Ereshefsky L, Saklad SR, Jann MW, Garcia N (1984). Explaining the pharmacokinetics of fluphenazine through computer simulations. (Abstract.). 19th Annual Midyear Clinical Meeting of the American Society of Hospital Pharmacists. Dallas, Texas.
^Janssen PA, Niemegeers CJ, Schellekens KH, Lenaerts FM, Verbruggen FJ, van Nueten JM, Marsboom RH, Hérin VV, Schaper WK (November 1970). "The pharmacology of fluspirilene (R 6218), a potent, long-acting and injectable neuroleptic drug". Arzneimittel-Forschung. 20 (11): 1689–98. PMID 4992598.
^Beresford R, Ward A (January 1987). "Haloperidol decanoate. A preliminary review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in psychosis". Drugs. 33 (1): 31–49. doi:10.2165/00003495-198733010-00002. PMID 3545764.
^Reyntigens AJ, Heykants JJ, Woestenborghs RJ, Gelders YG, Aerts TJ (1982). "Pharmacokinetics of haloperidol decanoate. A 2-year follow-up". International Pharmacopsychiatry. 17 (4): 238–46. doi:10.1159/000468580. PMID 7185768.
^Larsson M, Axelsson R, Forsman A (1984). "On the pharmacokinetics of perphenazine: a clinical study of perphenazine enanthate and decanoate". Current Therapeutic Research. 36 (6): 1071–88.
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