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Further information: Oncolytic virus
Oncolytic herpes virus
TEM micrograph of a herpes simplex virus.
Virus classification
(unranked):
Virus
Realm:
Duplodnaviria
Kingdom:
Heunggongvirae
Phylum:
Peploviricota
Class:
Herviviricetes
Order:
Herpesvirales
Family:
Orthoherpesviridae
Genus:
Simplexvirus
Species:
Human alphaherpesvirus 1
Many variants of herpes simplex virus have been considered for viral therapy of cancer; the early development of these was thoroughly reviewed in the journal Cancer Gene Therapy in 2002.[1] This page describes (in the order of development) the most notable variants—those tested in clinical trials: G207, HSV1716, NV1020 and Talimogene laherparepvec (previously Oncovex-GMCSF). These attenuated versions are constructed by deleting viral genes required for infecting or replicating inside normal cells but not cancer cells, such as ICP34.5, ICP6/UL39, and ICP47.
Electron Micrograph of herpes virus
^Varghese S, Rabkin SD (December 2002). "Oncolytic herpes simplex virus vectors for cancer virotherapy". Cancer Gene Therapy. 9 (12): 967–78. doi:10.1038/sj.cgt.7700537. PMID 12522436.
and 26 Related for: Oncolytic herpes virus information
of viruses including adenovirus, reovirus, measles, herpes simplex, Newcastle disease virus, and vaccinia have been clinically tested as oncolytic agents...
Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known by their taxonomic names Human alphaherpesvirus 1 and Human alphaherpesvirus 2, are two members...
Talimogene laherparepvec is a genetically engineered herpesvirus (an oncolyticherpesvirus). Two genes were removed – one that shuts down an individual...
vector for gene therapy and also as an oncolyticvirus. Of the many different viruses being explored for oncolytic potential, an adenovirus was the first...
the virus gained approval for the treatment of melanoma in late 2015. Viruses that have been reprogrammed to kill cancer cells are called oncolytic viruses...
Adeno-associated virus (AAV) has been researched as a viral vector in gene therapy for cancer treatment as an oncolyticvirus. Currently there are not...
genital herpes respectively, but other members in the herpes family include chickenpox (varicella/zoster), cytomegalovirus, and Epstein-Barr virus. There...
using viruses. Viruses that have been used for gene therapy are, adenovirus, lentivirus, retrovirus and the herpes simplex virus. The most common virus used...
wild-type Coxsackievirus A21, is being used in human clinical trials as an oncolyticvirus. SCAR-Fc (Soluble Receptor Analogue) is an experimental prophylactic...
Teserpaturev is an oncolyticvirus for treatment of malignant glioma. Also known as G47∆, teserpaturev is a genetically engineered herpes simplex virus type 1. Originally...
2003). "Effective therapy of metastatic ovarian cancer with an oncolyticherpes simplex virus incorporating two membrane fusion mechanisms". Clinical Cancer...
successful, complete inactivation of the virus in a space using a nonthermal plasma generator. Though the oncolytic effect of NDV was already documented in...
virus in "the wild". Viruses may also be attenuated via reverse genetics. Attenuation by genetics is also used in the production of oncolyticviruses...
The next generation of herpes simplex virus-based oncolytic immunotherapies for cancer treatment". Molecular Therapy Oncolytics. 31: 100729. doi:10.1016/j...
convert viruses into therapeutic agents by reprogramming viruses to treat diseases. There are three main branches of virotherapy: anti-cancer oncolytic viruses...
highly contagious, vaccine-preventable infectious disease caused by measles virus. Symptoms usually develop 10–12 days after exposure to an infected person...
of viruses including adenovirus, reovirus, measles, herpes simplex, Newcastle disease virus and vaccinia have now been clinically tested as oncolytic agents...
2006). "A mutant type 2 herpes simplex virus deleted for the protein kinase domain of the ICP10 gene is a potent oncolyticvirus". Molecular Therapy. 13...
Suryawanshi YR, Schulze AJ (July 2021). "OncolyticViruses for Malignant Glioma: On the Verge of Success?". Viruses. 13 (7): 1294. doi:10.3390/v13071294....
vasculature. Talimogene laherparepvec (T-VEC) (which is a herpes simplex virus type 1–derived oncolytic immunotherapy), was shown to be useful against metastatic...
treatment of solid tumors and hematological malignancies. Pelareorep is an oncolyticvirus, which means that it preferentially lyses cancer cells. Pelareorep...
the patient using oncolyticviruses. This approach was used in the drug talimogene laherparepvec, a variant of herpes simplex virus engineered to selectively...
PMID 30996096. "Design and Analysis of Shedding Studies for Virus or Bacteria-Based Gene Therapy and Oncolytic Products; Guidance for Industry | FDA". www.fda.gov...
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