Adenovirus varieties have been explored extensively as a viral vector for gene therapy and also as an oncolytic virus.[1]
Of the many different viruses being explored for oncolytic potential, an adenovirus was the first to be approved by a regulatory agency, the genetically modified H101 strain. It gained regulatory approval in 2005 from China's State Food and Drug Administration (SFDA) for the treatment of head and neck cancer.[2][3]
^Pandha K. J. Harrington; edited by Richard G. Vile, Hardev (2008). Viral therapy of cancer. Hoboken, N.J.: Wiley. pp. 1–13. ISBN 9780470019221. {{cite book}}: |first= has generic name (help)CS1 maint: multiple names: authors list (link)
^Frew SE, Sammut SM, Shore AF, Ramjist JK, Al-Bader S, Rezaie R, Daar AS, Singer PA (2008). "Chinese health biotech and the billion-patient market". Nature Biotechnology. 26 (1): 37–53. doi:10.1038/nbt0108-37. PMC 7096943. PMID 18183014.
^Garber K (2006). "China Approves World's First Oncolytic Virus Therapy for Cancer Treatment". JNCI Journal of the National Cancer Institute. 98 (5): 298–300. doi:10.1093/jnci/djj111. PMID 16507823.
and 24 Related for: Oncolytic adenovirus information
Adenovirus varieties have been explored extensively as a viral vector for gene therapy and also as an oncolytic virus. Of the many different viruses being...
melanoma; the approval was withdrawn in 2019. An oncolyticadenovirus, a genetically modified adenovirus named H101, was approved in China in 2005 for the...
cancer. In China, oncolyticadenovirus is an approved cancer treatment. Specific modifications on fiber proteins are used to target Adenovirus to certain cell...
investigational oncolytic virus that is in clinical trials for various cancers. It is an oncolytic A11/Ad3 Chimeric Group B Adenovirus, previously described...
Adenovirus E1B protein usually refers to one of two proteins transcribed from the E1B gene of the adenovirus: a 55kDa protein and a 19kDa protein. These...
Anna; Pesonen, Sari; Hemminki, Akseli (2014). "Serotype chimeric oncolyticadenovirus coding for GM-CSF for treatment of sarcoma in rodents and humans"...
and vaccine research Producing cell suspension cultures to support oncolyticadenovirus used in cancer immunotherapy Cell culture Adherent culture Bio-MEMS...
malignancies. AdVince, a type of gene therapy using a genetically modified oncolyticadenovirus and supported by the crowdfunding campaign iCancer was used in a...
many Oncolytic AAV applications that are in development and have been researched. AAV is a small virus that was found as a contaminant in adenovirus studies...
Åkerström G, Öberg K, Giandomenico V, Essand M (November 2011). "Oncolyticadenovirus modified with somatostatin motifs for selective infection of neuroendocrine...
Åkerström G, Öberg K, Giandomenico V, Essand M (November 2011). "Oncolyticadenovirus modified with somatostatin motifs for selective infection of neuroendocrine...
immunotherapy and especially on oncolytic adenoviruses. The goal of his research group is to create a new oncolyticadenovirus based treatment for cancers...
treat diseases. There are three main branches of virotherapy: anti-cancer oncolytic viruses, viral vectors for gene therapy and viral immunotherapy. These...
Joensuu has led several clinical trials and published articles on oncolyticadenovirus therapy, radiotherapy, chemoradiotherapy and prostate cancer. Dr...
cells, especially endothelial cells, is mediated by coxsackievirus and adenovirus receptor. Coxsackieviruses are divided into group A and group B viruses...
systems could improve the clinical benefit from these types of therapies. Oncolytic virotherapy is an emerging novel treatment that is under investigation...
was confirmed by a later trial of the same oncolytic virus, and also in Onyx 015, an oncolyticadenovirus. In describing the report authored by Pecora...
trials were for cancer treatment.: 7 Adenovirus vectors are useful for some cancer gene therapies because adenovirus can transiently insert genetic material...
including adenovirus, reovirus, measles, herpes simplex, Newcastle disease virus and vaccinia have now been clinically tested as oncolytic agents. T-Vec...
the immune system. The first oncolytic virus to be approved by a regulatory agency was a genetically modified adenovirus named H101 by Shanghai Sunway...
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