Octamer transcription factors are a family of transcription factors which binds to the "ATTTGCAT" DNA sequence.[1] Their DNA-binding domain is a POU domain.
There are eight Octamer proteins in humans (Oct1–11),[2] which have been renamed according to the different classes of POU domain.[3] Octamer-3/4, also known as POU5F1, is one of the Yamanaka factors, which are critical for the maintenance and self-renewal of embryonic stem cells.[3] On the other hand, Oct-1 and Oct-2 are widely expressed in adult tissues.[3] Oct-7, 8 and 9, also known as "brain factors", are predominantly expressed in the central nervous system during embryonic development.[3] Oct-6 expression is confined to embryonic stem cells and the developing nervous system and skin, while Oct-11 is also involved in skin differentiation.[3]
^Petryniak B, Staudt LM, Postema CE, McCormack WT, Thompson CB (1990). "Characterization of chicken octamer-binding proteins demonstrates that POU domain-containing homeobox transcription factors have been highly conserved during vertebrate evolution". Proc. Natl. Acad. Sci. U.S.A. 87 (3): 1099–103. Bibcode:1990PNAS...87.1099P. doi:10.1073/pnas.87.3.1099. PMC 53418. PMID 1967834.
^Oct-5 and Oct-10 are not found in humans, while Oct-3 and Oct-4 were identified as the same protein.
^ abcdeZhao, FQ (1 June 2013). "Octamer-binding transcription factors: genomics and functions". Frontiers in Bioscience (Landmark Edition). 18 (3): 1051–71. doi:10.2741/4162. PMC 4349413. PMID 23747866.
and 24 Related for: Octamer transcription factor information
Octamertranscriptionfactors are a family of transcriptionfactors which binds to the "ATTTGCAT" DNA sequence. Their DNA-binding domain is a POU domain...
molecular biology, a transcriptionfactor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information...
Transcriptionfactor TFIIA is a nuclear protein involved in the RNA polymerase II-dependent transcription of DNA. TFIIA is one of several general (basal)...
Transcriptionfactor II D (TFIID) is one of several general transcriptionfactors that make up the RNA polymerase II preinitiation complex. RNA polymerase...
Transcriptionfactor Sp1, also known as specificity protein 1* is a protein that in humans is encoded by the SP1 gene. The protein encoded by this gene...
Transformation Specific)) family is one of the largest families of transcriptionfactors and is unique to animals. There are 29 genes in humans, 28 in the...
Transcriptionfactor Sp7, also called osterix (Osx), is a protein that in humans is encoded by the SP7 gene. It is a member of the Sp family of zinc-finger...
The GATA transcriptionfactor family consists of six DNA-binding proteins (GATA1-6) that regulates transcription of DNA due to their ability to bind to...
Transcriptionfactor Jun is a protein that in humans is encoded by the JUN gene. c-Jun, in combination with protein c-Fos, forms the AP-1 early response...
Transcriptionfactor Sp4 is a protein that in humans is encoded by the SP4 gene. Sp4 transcriptionfactor has been shown to interact with E2F1. GRCh38:...
general transcriptionfactor-δ or basic transcriptionfactor 2 was characterized as an indispensable transcriptionfactor in vitro. This factor was also...
Activating transcriptionfactor, ATF, is a group of bZIP transcriptionfactors, which act as homodimers or heterodimers with a range of other bZIP factors. First...
sigma factor (σ factor or specificity factor) is a protein needed for initiation of transcription in bacteria. It is a bacterial transcription initiation...
finger transcriptionfactors or ZF-TFs, are transcriptionfactors composed of a zinc finger-binding domain and any of a variety of transcription-factor effector-domains...
eukaryotes. Homeobox genes encode homeodomain protein products that are transcriptionfactors sharing a characteristic protein fold structure that binds DNA to...
Transcriptionfactor Sp8 also known as specificity protein 8 (SP-8) or Btd transcriptionfactor (buttonhead) is a protein that in humans is encoded by...
Transcriptionfactor Sp2 is a protein that in humans is encoded by the SP2 gene. This gene encodes a member of the Sp subfamily of Sp/XKLF transcription...
Transcriptionfactor II B (TFIIB) is a general transcriptionfactor that is involved in the formation of the RNA polymerase II preinitiation complex (PIC)...
Sp3 transcriptionfactor, also known as SP3, refers to both a protein and the gene it is encoded by. This gene belongs to a family of Sp1 related genes...
Transcriptionfactor II F (TFIIF) is one of several general transcriptionfactors that make up the RNA polymerase II preinitiation complex. TFIIF is encoded...
A ρ factor (Rho factor) is a bacterial protein involved in the termination of transcription. Rho factor binds to the transcription terminator pause site...
names of three transcriptionfactors: the Pituitary-specific Pit-1 the Octamertranscriptionfactor proteins Oct-1 and Oct-2 (octamer sequence is ATGCAAAT)...