Transcription factor TFIIA is a nuclear protein involved in the RNA polymerase II-dependent transcription of DNA.[1] TFIIA is one of several general (basal) transcription factors (GTFs) that are required for all transcription events that use RNA polymerase II. Other GTFs include TFIID, a complex composed of the TATA binding protein TBP and TBP-associated factors (TAFs), as well as the factors TFIIB, TFIIE, TFIIF, and TFIIH. Together, these factors are responsible for promoter recognition and the formation of a transcription preinitiation complex (PIC) capable of initiating RNA synthesis from a DNA template.
^Høiby T, Zhou H, Mitsiou DJ, Stunnenberg HG (2007). "A facelift for the general transcription factor TFIIA". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1769 (7–8): 429–36. doi:10.1016/j.bbaexp.2007.04.008. hdl:2066/34866. PMID 17560669.
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