RNA polymerase II core promoter sequence-specific DNA binding
zinc ion binding
histone acetyltransferase activity
transferase activity
acyltransferase activity
RNA polymerase II complex recruiting activity
RNA polymerase II general transcription initiation factor activity
Cellular component
nucleus
nucleoplasm
transcription factor TFIID complex
nuclear body
transcription preinitiation complex
chromosome
protein-DNA complex
RNA polymerase II transcription regulator complex
Biological process
regulation of transcription, DNA-templated
transcription, DNA-templated
positive regulation of viral transcription
snRNA transcription by RNA polymerase II
viral process
transcription preinitiation complex assembly
positive regulation of core promoter binding
transcription initiation from RNA polymerase II promoter
protein acetylation
positive regulation by host of viral transcription
positive regulation of transcription initiation from RNA polymerase II promoter
transcriptional start site selection at RNA polymerase II promoter
transcription by RNA polymerase II
RNA polymerase II preinitiation complex assembly
RNA polymerase II core complex assembly
histone acetylation
DNA-templated transcription, initiation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
2959
229906
Ensembl
ENSG00000137947
ENSMUSG00000028271
UniProt
Q00403
P62915
RefSeq (mRNA)
NM_001514
NM_145546
RefSeq (protein)
NP_001505
NP_663521
Location (UCSC)
Chr 1: 88.85 – 88.89 Mb
Chr 3: 142.47 – 142.49 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Transcription factor II B (TFIIB) is a general transcription factor that is involved in the formation of the RNA polymerase II preinitiation complex (PIC)[5] and aids in stimulating transcription initiation. TFIIB is localised to the nucleus and provides a platform for PIC formation by binding and stabilising the DNA-TBP (TATA-binding protein) complex and by recruiting RNA polymerase II and other transcription factors. It is encoded by the TFIIB gene,[6][7] and is homologous to archaeal transcription factor B and analogous to bacterial sigma factors.[8]
^ abcGRCh38: Ensembl release 89: ENSG00000137947 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000028271 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Lewin, Benjamin (2004). Genes VIII. Upper Saddle River, NJ: Pearson Prentice Hall. pp. 636–637. ISBN 0-13-144946-X.
^Ha I, Lane WS, Reinberg D (August 1991). "Cloning of a human gene encoding the general transcription initiation factor IIB". Nature. 352 (6337): 689–95. Bibcode:1991Natur.352..689H. doi:10.1038/352689a0. PMID 1876184. S2CID 4267950.
^Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC (January 1994). "Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome". Human Molecular Genetics. 3 (1): 61–4. doi:10.1093/hmg/3.1.61. PMID 8162052.
^Burton SP, Burton ZF (2014). "The σ enigma: bacterial σ factors, archaeal TFB and eukaryotic TFIIB are homologs". Transcription. 5 (4): e967599. doi:10.4161/21541264.2014.967599. PMC 4581349. PMID 25483602.
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Global Information
