Sp2 transcription factor information

SP2
Identifiers
Aliases	SP2, Sp2, 4930480I16Rik, mKIAA0048, Sp2 transcription factor
External IDs	OMIM: 601801; MGI: 1926162; HomoloGene: 2340; GeneCards: SP2; OMA:SP2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	47,928,957 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	96,873,785 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; buccal mucosa cell; ; granulocyte; ; right testis; ; left testis; ; gastrocnemius muscle; ; popliteal artery; ; muscle of thigh; ; tibial arteries; ; monocyte;
	Top expressed in
	granulocyte; ; tail of embryo; ; genital tubercle; ; yolk sac; ; zygote; ; muscle of thigh; ; thymus; ; neural layer of retina; ; mesenteric lymph nodes; ; epiblast;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; histone deacetylase binding; protein binding; metal ion binding; nucleic acid binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; immune response; transcription, DNA-templated; multicellular organism growth; negative regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	6668
	78912
	ENSG00000167182
	ENSMUSG00000018678
	Q02086; Q9BRW5
	Q9D2H6
	NM_003110
	NM_001080964; NM_030220; NM_001363225; NM_001363226
	NP_003101
	NP_001074433; NP_084496; NP_001350154; NP_001350155
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor Sp2 is a protein that in humans is encoded by the SP2 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167182 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018678 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kingsley C, Winoto A (October 1992). "Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression". Mol Cell Biol. 12 (10): 4251–61. doi:10.1128/mcb.12.10.4251. PMC 360348. PMID 1341900.
^ Scohy S, Van Vooren P, Szpirer C, Szpirer J (October 1998). "Assignment1 of Sp genes to rat chromosome bands 7q36 (Sp1), 10q31→q32.1 (Sp2), 3q24→q31 (Sp3) and 6q33 (Sp4) and of the SP2 gene to human chromosome bands 17q21.3→q22 by in situ hybridization". Cytogenet Cell Genet. 81 (3–4): 273–4. doi:10.1159/000015044. PMID 9730617. S2CID 46786094.
^ "Entrez Gene: SP2 Sp2 transcription factor".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000167182 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000018678 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1341900-5] Kingsley C, Winoto A (October 1992). "Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression". Mol Cell Biol. 12 (10): 4251–61. doi:10.1128/mcb.12.10.4251. PMC 360348. PMID 1341900.

[pmid9730617-6] Scohy S, Van Vooren P, Szpirer C, Szpirer J (October 1998). "Assignment1 of Sp genes to rat chromosome bands 7q36 (Sp1), 10q31→q32.1 (Sp2), 3q24→q31 (Sp3) and 6q33 (Sp4) and of the SP2 gene to human chromosome bands 17q21.3→q22 by in situ hybridization". Cytogenet Cell Genet. 81 (3–4): 273–4. doi:10.1159/000015044. PMID 9730617. S2CID 46786094.

[entrez-7] "Entrez Gene: SP2 Sp2 transcription factor".

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