Sp8 transcription factor information

SP8
Identifiers
Aliases	SP8, BTD, Sp8 transcription factor
External IDs	OMIM: 608306; MGI: 2443471; HomoloGene: 18548; GeneCards: SP8; OMA:SP8 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	20,786,886 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	118,816,311 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; sural nerve; ; testicle; ; ventricular zone; ; gonad; ; olfactory zone of nasal mucosa; ; ganglionic eminence; ; nasal epithelium; ; mucosa of paranasal sinus; ; muscle of thigh;
	Top expressed in
	Rostral migratory stream; ; olfactory bulb; ; lateral septal nucleus; ; primitive streak; ; prostate; ; respiratory epithelium; ; olfactory epithelium; ; lobe of prostate; ; tail of embryo; ; ventricular zone;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; metal ion binding; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	proximal/distal pattern formation; regulation of transcription, DNA-templated; dorsal/ventral pattern formation; embryonic limb morphogenesis; transcription, DNA-templated; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	221833
	320145
	ENSG00000164651
	ENSMUSG00000048562
	Q8IXZ3
	Q8BMJ8
	NM_182700; NM_198956
	NM_177082; NM_001379379; NM_001379380
	NP_874359; NP_945194
	NP_796056; NP_001366308; NP_001366309
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor Sp8 also known as specificity protein 8 (SP-8) or Btd transcription factor (buttonhead)^[5] is a protein that in humans is encoded by the SP8 gene.^[6]^[7] Sp8 is a transcription factor in the Sp/KLF family.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164651 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000048562 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Treichel D, Schöck F, Jäckle H, Gruss P, Mansouri A (November 2003). "mBtd is required to maintain signaling during murine limb development" (PDF). Genes & Development. 17 (21): 2630–5. doi:10.1101/gad.274103. PMC 280612. PMID 14597661.
^ Bell SM, Schreiner CM, Waclaw RR, Campbell K, Potter SS, Scott WJ (October 2003). "Sp8 is crucial for limb outgrowth and neuropore closure". Proceedings of the National Academy of Sciences of the United States of America. 100 (21): 12195–200. doi:10.1073/pnas.2134310100. PMC 218735. PMID 14526104.
^ "Entrez Gene: Sp8 transcription factor".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164651 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000048562 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid14597661-5] Treichel D, Schöck F, Jäckle H, Gruss P, Mansouri A (November 2003). "mBtd is required to maintain signaling during murine limb development" (PDF). Genes & Development. 17 (21): 2630–5. doi:10.1101/gad.274103. PMC 280612. PMID 14597661.

[pmid14526104-6] Bell SM, Schreiner CM, Waclaw RR, Campbell K, Potter SS, Scott WJ (October 2003). "Sp8 is crucial for limb outgrowth and neuropore closure". Proceedings of the National Academy of Sciences of the United States of America. 100 (21): 12195–200. doi:10.1073/pnas.2134310100. PMC 218735. PMID 14526104.

[entrez-7] "Entrez Gene: Sp8 transcription factor".

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