Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
Nicotinamide adenine dinucleotide phosphate, abbreviated NADP+ or, in older notation, TPN (triphosphopyridine nucleotide), is a cofactor used in anabolic reactions, such as the Calvin cycle and lipid and nucleic acid syntheses, which require NADPH as a reducing agent ('hydrogen source'). NADPH is the reduced form, whereas NADP+ is the oxidized form. NADP+ is used by all forms of cellular life.[1]
NADP+ differs from NAD+ by the presence of an additional phosphate group on the 2' position of the ribose ring that carries the adenine moiety. This extra phosphate is added by NAD+ kinase and removed by NADP+ phosphatase.[2]
^Spaans SK, Weusthuis RA, van der Oost J, Kengen SW (2015). "NADPH-generating systems in bacteria and archaea". Frontiers in Microbiology. 6: 742. doi:10.3389/fmicb.2015.00742. PMC 4518329. PMID 26284036.
^Kawai S, Murata K (April 2008). "Structure and function of NAD kinase and NADP phosphatase: key enzymes that regulate the intracellular balance of NAD(H) and NADP(H)". Bioscience, Biotechnology, and Biochemistry. 72 (4): 919–30. doi:10.1271/bbb.70738. PMID 18391451.
and 22 Related for: Nicotinamide adenine dinucleotide phosphate information
Nicotinamideadeninedinucleotide (NAD) is a coenzyme central to metabolism. Found in all living cells, NAD is called a dinucleotide because it consists...
Nicotinamideadeninedinucleotidephosphate, abbreviated NADP+ or, in older notation, TPN (triphosphopyridine nucleotide), is a cofactor used in anabolic...
In cells, nicotinamide is incorporated into NAD+ and nicotinamideadeninedinucleotidephosphate (NADP+). NAD+ and NADP+ are cofactors in a wide variety...
Nicotinic acid adeninedinucleotidephosphate (NAADP) is a Ca2+-mobilizing second messenger synthesised in response to extracellular stimuli. Like its...
derivative nicotinamide (niacinamide) is a component of the coenzymes nicotinamideadeninedinucleotide (NAD) and nicotinamideadeninedinucleotidephosphate (NADP+)...
amide nicotinamide (niacinamide) is a component of the coenzymes nicotinamideadeninedinucleotide (NAD) and nicotinamideadeninedinucleotidephosphate (NADP+)...
adenosine triphosphate (ATP) and the cofactors nicotinamideadeninedinucleotide (NAD), flavin adeninedinucleotide (FAD) and Coenzyme A. It also has functions...
In biochemistry, flavin adeninedinucleotide (FAD) is a redox-active coenzyme associated with various proteins, which is involved with several enzymatic...
NAD+, or nicotinamideadeninedinucleotide, is a dinucleotide, containing two nucleotides. One of the nucleotides it contains is an adenine group, while...
molecules that participate in energetic processes: reduced nicotinamideadeninedinucleotidephosphate (NADPH) and ATP. In plants, algae, and cyanobacteria...
and niacin. In humans, several enzymes use NMN to generate nicotinamideadeninedinucleotide (NADH). In mice, it has been proposed that NMN is absorbed...
acid by the enzyme shikimate dehydrogenase, which uses nicotinamideadeninedinucleotidephosphate (NADPH) as a cofactor. The shikimate pathway is a seven-step...
NADPH oxidase (nicotinamideadeninedinucleotidephosphate oxidase) is a membrane-bound enzyme complex that faces the extracellular space. It can be found...
also fructose 6-phosphate are an intermediate of the pentose-phosphate pathway which generates nicotinamideadeninedinucleotidephosphate (NADPH) and pentoses...
certain conditions. Vitamin B4: can refer to the distinct chemicals choline, adenine, or carnitine. Choline is synthesized by the human body, but not sufficiently...
For example, nicotinamideadeninedinucleotide (NAD), flavin adeninedinucleotide (FAD), and nicotinamideadeninedinucleotidephosphate (NADP) all contain...
that regulate cysteine exploitation, glutathione state, nicotinamideadeninedinucleotidephosphate (NADP) function, lipid peroxidation, and iron homeostasis...
(−)-Limonene-3-hydroxylase (L3OH), using O2 and then nicotinamideadeninedinucleotidephosphate (NADPH) catalyzes the allylic hydroxylation of (−)-limonene...
as well. CGD is a caused by decreased production of nicotinamideadeninedinucleotidephosphate (NADPH) oxidase by neutrophils. Hypomorphic RAG mutations...
pathway has two metabolic functions: (1) generation of nicotinamideadeninedinucleotidephosphate (reduced NADPH), for reductive biosynthesis, and (2)...
encoded by the AKR1B1 gene in humans. It is a reduced nicotinamide-adeninedinucleotidephosphate (NADPH)-dependent enzyme catalyzing the reduction of...
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