AKR1B1 information

AKR1B1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2PDQ, 1IEI, 2ACQ, 2FZB, 2IKH, 2PDH, 3LD5, 2IQ0, 1T40, 2PDG, 2PDB, 3GHR, 2NVD, 2PD5, 2PDU, 3M4H, 4GCA, 2PDX, 2I17, 1US0, 1AZ1, 2R24, 3M64, 1MAR, 3ONC, 1Z3N, 3ONB, 2ACR, 2DUZ, 2DUX, 2HVO, 2FZ8, 4PUW, 4XZH, 4QBX, 4JIR, 2PD9, 3LQL, 1ABN, 2PDW, 4PR4, 2PDI, 3LEP, 2PDJ, 4PUU, 2DV0, 3LEN, 3G5E, 1EF3, 4LB3, 2PDC, 3LBO, 2PDP, 2FZD, 4NKC, 2PZN, 2ISF, 3RX4, 2PDL, 3Q65, 4PRT, 4Q7B, 4QX4, 2FZ9, 2IKJ, 2J8T, 4IGS, 2IS7, 3V35, 1Z8A, 1XGD, 3T42, 2QXW, 4QR6, 1X96, 4RPQ, 2HV5, 2NVC, 2F2K, 3BCJ, 3LZ3, 3V36, 2PDK, 3GHU, 3GHS, 2ACU, 2PDM, 4LAZ, 1T41, 2IKG, 3MB9, 2PDF, 4PRR, 2PDN, 3LQG, 4XZI, 3LZ5, 2AGT, 3S3G, 1PWL, 3M0I, 2PF8, 3RX2, 2IPW, 3MC5, 3DN5, 4QXI, 2HVN, 2INZ, 1X97, 2PDY, 3RX3, 1PWM, 4LBR, 3Q67, 4LAU, 1Z89, 2IKI, 3P2V, 1X98, 1AZ2, 2PFH, 3U2C, 2ACS, 3GHT, 4LB4, 2INE, 1EL3, 2I16, 2IQD, 2PEV, 4LBS, 1ADS, 4YU1, 4YS1
Identifiers
Aliases	AKR1B1, ADR, ALDR1, ALR2, AR, aldo-keto reductase family 1, member B1 (aldose reductase), aldo-keto reductase family 1 member B
External IDs	OMIM: 103880; MGI: 1353494; HomoloGene: 133743; GeneCards: AKR1B1; OMA:AKR1B1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	134,459,284 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	34,294,413 bp
RNA expression pattern
	Top expressed in
	left adrenal gland; ; olfactory bulb; ; spinal ganglia; ; seminal vesicula; ; trigeminal ganglion; ; gastrocnemius muscle; ; tibial nerve; ; renal medulla; ; placenta; ; left ventricle;
	Top expressed in
	urinary bladder; ; secondary oocyte; ; adrenal gland; ; quadriceps femoris muscle; ; spermatocyte; ; muscle tissue; ; skeletal muscle tissue; ; heart; ; esophagus; ; white adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	aldo-keto reductase (NADP) activity; electron transfer activity; oxidoreductase activity; glyceraldehyde oxidoreductase activity; alditol:NADP+ 1-oxidoreductase activity; alcohol dehydrogenase (NADP+) activity; retinal dehydrogenase activity; allyl-alcohol dehydrogenase activity; NADP-retinol dehydrogenase activity;
Cellular component	mast cell granule; Schwann cell microvillus; Schmidt-Lanterman incisure; nucleoplasm; plasma membrane bounded cell projection cytoplasm; perinuclear region of cytoplasm; paranodal junction; extracellular exosome; extracellular space; cytoplasm; cytosol;
Biological process	stress-activated protein kinase signaling cascade; cellular response to peptide; daunorubicin metabolic process; doxorubicin metabolic process; maternal process involved in female pregnancy; monosaccharide metabolic process; norepinephrine metabolic process; fructose biosynthetic process; response to thyroid hormone; response to stress; response to water deprivation; cellular response to methylglyoxal; response to organic substance; C21-steroid hormone biosynthetic process; tissue homeostasis; inner medullary collecting duct development; positive regulation of receptor signaling pathway via JAK-STAT; positive regulation of smooth muscle cell proliferation; cellular response to hydrogen peroxide; sorbitol biosynthetic process; renal water homeostasis; regulation of urine volume; negative regulation of apoptotic process; renal system development; carbohydrate metabolic process; electron transport chain; cellular hyperosmotic salinity response; retinoid metabolic process; metanephric collecting duct development; retinol metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	231
	11677
	ENSG00000085662
	ENSMUSG00000001642
	P15121
	P45376
	NM_001628; NM_001346142
	NM_009658
	NP_001333071; NP_001619
	NP_033788
	Wikidata
View/Edit Human	View/Edit Mouse

Aldo-keto reductase family 1, member B1 (AKR1B1), also known as aldose reductase, is an enzyme that is encoded by the AKR1B1 gene in humans.^[5]^[6] It is a reduced nicotinamide-adenine dinucleotide phosphate (NADPH)-dependent enzyme catalyzing the reduction of various aldehydes and ketones to the corresponding alcohol. The involvement of AKR1B1 in oxidative stress diseases, cell signal transduction, and cell proliferation process endows AKR1B1 with potential as a therapeutic target.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000085662 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001642 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Graham A, Heath P, Morten JE, Markham AF (March 1991). "The human aldose reductase gene maps to chromosome region 7q35". Human Genetics. 86 (5): 509–14. doi:10.1007/BF00194644. PMID 1901827. S2CID 34446965.
^ "Entrez Gene: AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000085662 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001642 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1901827-5] Graham A, Heath P, Morten JE, Markham AF (March 1991). "The human aldose reductase gene maps to chromosome region 7q35". Human Genetics. 86 (5): 509–14. doi:10.1007/BF00194644. PMID 1901827. S2CID 34446965.

[entrez-6] "Entrez Gene: AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)".

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