Immune response against an organism's own healthy cells
For journal, see Autoimmunity (journal).
Medical condition
Autoimmunity
Parts of body affected by autoimmune diseases
Specialty
Immunology
In immunology, autoimmunity is the system of immune responses of an organism against its own healthy cells, tissues and other normal body constituents.[1][2] Any disease resulting from this type of immune response is termed an "autoimmune disease". Prominent examples include celiac disease, diabetes mellitus type 1, Henoch–Schönlein purpura, systemic lupus erythematosus, Sjögren syndrome, eosinophilic granulomatosis with polyangiitis, Hashimoto's thyroiditis, Graves' disease, idiopathic thrombocytopenic purpura, Addison's disease, rheumatoid arthritis, ankylosing spondylitis, polymyositis, dermatomyositis, and multiple sclerosis. Autoimmune diseases are very often treated with steroids.[3]
Autoimmunity means presence of antibodies or T cells that react with self-protein and is present in all individuals, even in normal health state. It causes autoimmune diseases if self-reactivity can lead to tissue damage.[4]
^The Editors of Encyclopaedia Britannica (20 November 2018). "Autoimmunity". Health & Medicine. Encyclopædia Britannica. Archived from the original on 5 January 2021. Retrieved 5 January 2020.
^Delves PJ (1998-01-01). "Autoimmunity". In Delves PJ (ed.). Encyclopedia of Immunology (Second ed.). Oxford: Elsevier. pp. 292–296. doi:10.1006/rwei.1999.0075. ISBN 978-0-12-226765-9. Retrieved 2021-01-06.
^Patt H, Bandgar T, Lila A, Shah N (December 2013). "Management issues with exogenous steroid therapy". Indian Journal of Endocrinology and Metabolism. 17 (Suppl 3): S612–S617. doi:10.4103/2230-8210.123548. PMC 4046616. PMID 24910822.
^Diamond B, Lipsky PE (2014). "Autoimmunity and Autoimmune Diseases". In Kasper D, Fauci A, Hauser S, Longo D (eds.). Harrison's Principles of Internal Medicine (19th ed.). New York, NY: McGraw-Hill Education. Archived from the original on 5 January 2021. Retrieved 2021-01-05.
autoimmunity"). Autoimmunity should not be confused with alloimmunity. While a high level of autoimmunity is unhealthy, a low level of autoimmunity may...
The Journal of Autoimmunity is a peer-reviewed medical journal covering research on all aspects of autoimmunity. It was established in 1988 and is published...
Autoimmunity Reviews is a bimonthly peer-reviewed medical journal publishing review articles pertaining to autoimmunity. It was established in 2002 and...
Protective autoimmunity is a condition in which cells of the adaptive immune system contribute to maintenance of the functional integrity of a tissue,...
thus leading to tissue pathology (autoimmunity). Molecular mimicry is one of several ways in which autoimmunity can be evoked. A molecular mimicking...
sufficient evidence to indicate that these diseases are caused by autoimmunity. Autoimmunity Autoantibody For detailed information on Goodpasture syndrome...
In Elkon KB (ed.). Apoptosis and Its Relevance to Autoimmunity. Current Directions in Autoimmunity. Vol. 9. Karger. pp. 173–187. doi:10.1159/000090781...
cell repertoire. This causes autoimmunity in the body. Lanzavecchia, A (1995). "How can cryptic epitopes trigger autoimmunity?". J. Exp. Med. 181 (6): 1945–8...
characteristics of autoimmunity. The decreased ability of the immune system to clear infections in these patients may be responsible for causing autoimmunity through...
to determine how agents affect human autoimmunity, because of this much of the current knowledge about autoimmunity in response to immunotoxic agents comes...
systemic sclerosis and occupational exposure and review of the literature". Autoimmunity Reviews. 13 (2): 151–56. doi:10.1016/j.autrev.2013.10.002. PMID 24129037...
Journal (IMAJ). He is co-editor-in-chief of Autoimmunity Reviews, and co-editor of the Journal of Autoimmunity, and member of the editorial board of the...
prevention of autoimmunity in mice and rats. Initial observations showed removal of the thymus of a newborn mouse resulted in autoimmunity, which could...
There is no known preventive measure for type 1 diabetes. However, islet autoimmunity and multiple antibodies can be a strong predictor of the onset of type...
activates zonulin signaling irrespective of the genetic expression of autoimmunity, leading to increased intestinal permeability of macromolecules. Zonula...
research team at the Autoimmunity Research Foundation, a California-based nonprofit, where she has published papers on autoimmunity in the context of the...
immune system and The Altered Glycan Theory of Autoimmunity: a critical review". Journal of Autoimmunity. 57 (6): 1–13. doi:10.1016/j.jaut.2014.12.002...
treat them as foreign, stimulating an immune response and resulting in autoimmunity. People with APECED develop an autoimmune disease that affects multiple...
effecting or regulating allergic responses, innate and adaptive immunity, autoimmunity, and inflammation. Across systems, mast cells serve as the main effector...
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