Nuclear respiratory factor 1, also known as Nrf1, Nrf-1, NRF1 and NRF-1, encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1.[citation needed]
^ abcGRCh38: Ensembl release 89: ENSG00000106459 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000058440 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Nuclear respiratory factor 1, also known as Nrf1, Nrf-1, NRF1 and NRF-1, encodes a protein that homodimerizes and functions as a transcription factor...
degeneration. Similar results have also been observed in Nrf1 central nervous-specific knockout mice. The Nrf1-sMaf heterodimers regulate genes responsible for...
magazine nrf, the ISO 639-3 code for Jèrriais and Guernésiais languages NRF1, Nuclear Respiratory Factor This disambiguation page lists articles associated...
Nuclear factor erythroid 2-related factor 1 (Nrf1) also known as nuclear factor erythroid-2-like 1 (NFE2L1) is a protein that in humans is encoded by the...
1006/bbrc.1997.6943. PMID 9240432. Venugopal R, Jaiswal AK (December 1996). "Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant...
thought to downregulate PGC-1α, but upregulate its downstream effectors, NRF1 and NRF2. Akt itself is activated by PIP3, often upregulated by PI3K after...
G, Juget M, Roussis V, Roussakis C (2002). "Effect of four genes (ALDH1, NRF1, JAM and KBL) on proliferation arrest in a non-small cell bronchopulmonary...
interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPARGC1...
(NRF2/GABPA), and together with NRF-2 coactivates nuclear respiratory factor 1 (NRF1). The NRFs, in turn, activate the mitochondrial transcription factor A (tfam)...
systems, as well as intrauterine development. Transcription factors TFIIB and NRF1 both occur twice within the first 100 base pairs upstream from the transcription...
PMID 8380166. Venugopal R, Jaiswal AK (December 1998). "Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated...
upregulates the transcriptional activity of nuclear respiratory factors 1 and 2 (NRF1 and NRF2) and stimulates the expression of peroxisome proliferator-activated...
complex 0.834 P53F Tumor suppressor p53 (3' half site) 0.921 TCFF TCF11/LCP-F1/Nrf1 homodimers 1.000 FKHD Fork head homologous X binds DNA with a dual sequence...
co-immunoprecipitation (Co-IP) experiments revealed interacting protein NRF1 nuclear respiratory factor 1 This gene encodes a protein that homodimerizes...
predicted to bind to conserved sites on the promoter region (GXP_7545710) are NRF1, E2F, ZF5, and AHR. The human C5orf24 gene has three mRNA transcript variants...
for transcription factors such as GATA binding factors, SMAD3, TP63 and NRF1. MIPOL1 is ubiquitously expressed at low levels in humans, with highest expression...
regulation have been described and include the minimal promoter, Vitamin D and NRF1 response elements. PCFT operates most efficiently when there is a strong...
humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1". Proc. Natl. Acad. Sci. U.S.A. 100 (14): 8466–71. Bibcode:2003PNAS..100...
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