C6orf136 information

C6orf136
Identifiers
Aliases	C6orf136, chromosome 6 open reading frame 136
External IDs	MGI: 1916912 HomoloGene: 17027 GeneCards: C6orf136
Gene location (Human)
Chr.	Chromosome 6 (human)
End	30,653,210 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	36,208,323 bp
RNA expression pattern
	Top expressed in
	cerebellar cortex; ; cerebellar hemisphere; ; superior frontal gyrus; ; Brodmann area 9; ; rectum; ; left ventricle; ; hypothalamus; ; duodenum; ; putamen; ; pituitary gland;
	Top expressed in
	Paneth cell; ; digastric muscle; ; sternocleidomastoid muscle; ; temporal muscle; ; triceps brachii muscle; ; right ventricle; ; substantia nigra; ; myocardium of ventricle; ; thoracic diaphragm; ; motor neuron;
	More reference expression data
	n/a
Orthologs
	221545
	69662
ENSG00000233641; ENSG00000233164; ENSG00000237012; ENSG00000237100; ENSG00000204564;
	ENSG00000224120; ENSG00000206487
	ENSMUSG00000050705
	Q5SQH8
	n/a
	NM_001109938; NM_001161376; NM_145029
	NM_001033630
	NP_001103408; NP_001154848; NP_659466
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

C6orf136 (Chromosome 6 Open Reading Frame 136) is a protein in humans (Homo sapiens) encoded by the C6orf136 gene. The gene is conserved in mammals, mollusks, as well some porifera.^[5] While the function of the gene is currently unknown, C6orf136 has been shown to be hypermethylated in response to FOXM1 expression in Head Neck Squamous Cell Carcinoma (HNSCC) tissue cells.^[6] Additionally, elevated expression of C6orf136 has been associated with improved survival rates in patients with bladder cancer.^[7] C6orf136 has three known isoforms.

^ ^a ^b ^c ENSG00000233164, ENSG00000237012, ENSG00000237100, ENSG00000204564, ENSG00000224120, ENSG00000206487 GRCh38: Ensembl release 89: ENSG00000233641, ENSG00000233164, ENSG00000237012, ENSG00000237100, ENSG00000204564, ENSG00000224120, ENSG00000206487 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000050705 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "C6orf136 orthologs". NCBI. Retrieved 2020-09-30.
^ Hwang S, Mahadevan S, Qadir F, Hutchison IL, Costea DE, Neppelberg E, et al. (December 2013). "Identification of FOXM1-induced epigenetic markers for head and neck squamous cell carcinomas". Cancer. 119 (24): 4249–58. doi:10.1002/cncr.28354. PMID 24114764.
^ Tao T, Yuan S, Liu J, Shi D, Peng M, Li C, Wu S (February 2020). "Cancer stem cell-specific expression profiles reveal emerging bladder cancer biomarkers and identify circRNA_103809 as an important regulator in bladder cancer". Aging. 12 (4): 3354–3370. doi:10.18632/aging.102816. PMC 7066924. PMID 32065779.

[refGRCh38Ensembl-1] ENSG00000233164, ENSG00000237012, ENSG00000237100, ENSG00000204564, ENSG00000224120, ENSG00000206487 GRCh38: Ensembl release 89: ENSG00000233641, ENSG00000233164, ENSG00000237012, ENSG00000237100, ENSG00000204564, ENSG00000224120, ENSG00000206487 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000050705 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "C6orf136 orthologs". NCBI. Retrieved 2020-09-30.

[6] Hwang S, Mahadevan S, Qadir F, Hutchison IL, Costea DE, Neppelberg E, et al. (December 2013). "Identification of FOXM1-induced epigenetic markers for head and neck squamous cell carcinomas". Cancer. 119 (24): 4249–58. doi:10.1002/cncr.28354. PMID 24114764.

[7] Tao T, Yuan S, Liu J, Shi D, Peng M, Li C, Wu S (February 2020). "Cancer stem cell-specific expression profiles reveal emerging bladder cancer biomarkers and identify circRNA_103809 as an important regulator in bladder cancer". Aging. 12 (4): 3354–3370. doi:10.18632/aging.102816. PMC 7066924. PMID 32065779.