In enzymology, a NADPH peroxidase (EC 1.11.1.2) is an enzyme that catalyzes the chemical reaction
NADPH + H+ + H2O2 NADP+ + 2 H2O
The 3 substrates of this enzyme are NADPH, H+, and H2O2, whereas its two products are NADP+ and H2O.
This enzyme belongs to the family of oxidoreductases, specifically those acting on a peroxide as acceptor (peroxidases). The systematic name of this enzyme class is NADPH:hydrogen-peroxide oxidoreductase. Other names in common use include TPNH peroxidase, NADP peroxidase, nicotinamide adenine dinucleotide phosphate peroxidase, TPN peroxidase, triphosphopyridine nucleotide peroxidase, and NADPH2 peroxidase.
In enzymology, a NADPHperoxidase (EC 1.11.1.2) is an enzyme that catalyzes the chemical reaction NADPH + H+ + H2O2 ⇌ {\displaystyle \rightleftharpoons...
A direct assay by linking the peroxidase reaction with glutathione reductase with measurement of the conversion of NADPH to NADP is widely used. The other...
HMP Shunt) is a metabolic pathway parallel to glycolysis. It generates NADPH and pentoses (5-carbon sugars) as well as ribose 5-phosphate, a precursor...
TMs tethered to NADPH oxidase). Topological studies place this peroxidase domain on the opposite side of the membrane from the NADPH oxidase domain. hDUOX1...
EC 1.11 includes oxidoreductases that act on peroxide as an acceptor (peroxidases) EC 1.12 includes oxidoreductases that act on hydrogen as donors EC 1...
form in eosinophil and thyroid peroxidases. Heme l is one important characteristic of animal peroxidases; plant peroxidases incorporate heme B. Lactoperoxidase...
oxidative stress. Here, trypanothione-dependent enzymes such as tryparedoxin peroxidase (TryP) reduce peroxides using electrons donated either directly from trypanothione...
reductase, using NADPH as an electron donor. The glutathione system includes glutathione, glutathione reductase, glutathione peroxidases, and glutathione...
Glutathione peroxidase 4, also known as GPX4, is an enzyme that in humans is encoded by the GPX4 gene. GPX4 is a phospholipid hydroperoxidase that protects...
divide up leukocyte (white blood cell) populations based on their size and peroxidase activity. Specific stains bind to myeloperoxidase, and individuals who...
Dietz KJ (January 2016). "Thiol-Based Peroxidases and Ascorbate Peroxidases: Why Plants Rely on Multiple Peroxidase Systems in the Photosynthesizing Chloroplast...
Setiadi H, Wu R (August 2005). "Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract...
1 μmole per gram of wet weight, about 10 times the concentration of NADP+ and NADPH in the same cells. The actual concentration of NAD+ in cell cytosol is harder...
state is converted to the reduced state by NADPH. This conversion is catalyzed by glutathione reductase: NADPH + GSSG + H2O → 2 GSH + NADP+ + OH− GSH protects...
resorufin (used in many assays combining for example horseradish peroxidase (HRP), or NADH, NADPH using enzymes). 7-ethoxyresorufin, a compound used as the substrate...
Co-oxidation by peroxidasesNADPH-cytochrome P450 reductase Cytochrome P450 reductase, also known as NADPH:ferrihemoprotein oxidoreductase, NADPH:hemoprotein...
pathways leading to the hemoglobin damage. NADPH deficiency can cause a dysfunction in glutathione peroxidase which is an enzyme that converts hydrogen...
equivalent of dihydrogen (H2), and the acceptor is a dioxygen. Similarly, a peroxidase (another subclass of oxidoreductases) will use a peroxide (H2O2) as the...
NADPH oxidase (NOX2 in humans) activity. NADPH is the key substrate of NOX2, and bears reducing power. Glycogen breakdown is vital to produce NADPH....
yeast peroxisomal antioxidant enzyme PMP20. Biochemically, PRDX5 is a peroxidase that can use cytosolic or mitochondrial thioredoxins to reduce alkyl hydroperoxides...
the coenzyme NADPH. This reaction is catalyzed by the enzyme glutathione reductase. Antioxidant enzymes, such as glutathione peroxidases and peroxiredoxins...
S-transferase activity. PPA also causes a decrease in glutathione and Glutathione peroxidase activity. The epoxide of allylcatechol may also be generated from the...
Reduced glutathione reduces the oxidized form of the enzyme glutathione peroxidase, which in turn reduces hydrogen peroxide (H2O2), a dangerously reactive...
of the allele. NADPH Oxidase regulates oxidative stress by conjugating with reactive oxygen species in cells. Polymorphisms in NADPH Oxidase p22phox...
released by a reaction will be detected. The detection of horseradish peroxidase by enzymatic chemiluminescence (ECL) is a common method of detecting antibodies...
(February 1997). "The human homologue of a bovine non-selenium glutathione peroxidase is a novel keratinocyte growth factor-regulated gene". Oncogene. 14 (8):...
Global Information