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NADPH peroxidase information


NADPH peroxidase
Identifiers
EC no.1.11.1.2
CAS no.9029-51-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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In enzymology, a NADPH peroxidase (EC 1.11.1.2) is an enzyme that catalyzes the chemical reaction

NADPH + H+ + H2O2 NADP+ + 2 H2O

The 3 substrates of this enzyme are NADPH, H+, and H2O2, whereas its two products are NADP+ and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a peroxide as acceptor (peroxidases). The systematic name of this enzyme class is NADPH:hydrogen-peroxide oxidoreductase. Other names in common use include TPNH peroxidase, NADP peroxidase, nicotinamide adenine dinucleotide phosphate peroxidase, TPN peroxidase, triphosphopyridine nucleotide peroxidase, and NADPH2 peroxidase.

and 28 Related for: NADPH peroxidase information

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NADPH peroxidase

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In enzymology, a NADPH peroxidase (EC 1.11.1.2) is an enzyme that catalyzes the chemical reaction NADPH + H+ + H2O2 ⇌ {\displaystyle \rightleftharpoons...

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Glutathione peroxidase

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A direct assay by linking the peroxidase reaction with glutathione reductase with measurement of the conversion of NADPH to NADP is widely used. The other...

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Pentose phosphate pathway

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HMP Shunt) is a metabolic pathway parallel to glycolysis. It generates NADPH and pentoses (5-carbon sugars) as well as ribose 5-phosphate, a precursor...

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Heme

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form in eosinophil and thyroid peroxidases. Heme l is one important characteristic of animal peroxidases; plant peroxidases incorporate heme B. Lactoperoxidase...

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Dual oxidase 1

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TMs tethered to NADPH oxidase). Topological studies place this peroxidase domain on the opposite side of the membrane from the NADPH oxidase domain. hDUOX1...

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Oxidoreductase

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EC 1.11 includes oxidoreductases that act on peroxide as an acceptor (peroxidases) EC 1.12 includes oxidoreductases that act on hydrogen as donors EC 1...

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NADH peroxidase

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peroxidase, NAD peroxidase, diphosphopyridine nucleotide peroxidase, NADH-peroxidase, nicotinamide adenine dinucleotide peroxidase, and NADH2 peroxidase. The crystal...

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Trypanothione

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oxidative stress. Here, trypanothione-dependent enzymes such as tryparedoxin peroxidase (TryP) reduce peroxides using electrons donated either directly from trypanothione...

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GPX4

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Glutathione peroxidase 4, also known as GPX4, is an enzyme that in humans is encoded by the GPX4 gene. GPX4 is a phospholipid hydroperoxidase that protects...

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Antioxidant

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reductase, using NADPH as an electron donor. The glutathione system includes glutathione, glutathione reductase, glutathione peroxidases, and glutathione...

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Myeloperoxidase deficiency

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divide up leukocyte (white blood cell) populations based on their size and peroxidase activity. Specific stains bind to myeloperoxidase, and individuals who...

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Dual oxidase 2

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Setiadi H, Wu R (August 2005). "Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract...

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Nicotinamide adenine dinucleotide

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1 μmole per gram of wet weight, about 10 times the concentration of NADP+ and NADPH in the same cells. The actual concentration of NAD+ in cell cytosol is harder...

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Reactive oxygen species

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Dietz KJ (January 2016). "Thiol-Based Peroxidases and Ascorbate Peroxidases: Why Plants Rely on Multiple Peroxidase Systems in the Photosynthesizing Chloroplast...

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Drug metabolism

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Co-oxidation by peroxidases NADPH-cytochrome P450 reductase Cytochrome P450 reductase, also known as NADPH:ferrihemoprotein oxidoreductase, NADPH:hemoprotein...

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Catalase

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publications by Beers & Sizer and Aebi. Enzyme kinetics Glutathione peroxidase Peroxidase Superoxide dismutase GRCh38: Ensembl release 89: ENSG00000121691...

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Glutathione

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state is converted to the reduced state by NADPH. This conversion is catalyzed by glutathione reductase: NADPH + GSSG + H2O → 2 GSH + NADP+ + OH− GSH protects...

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Dehydrogenase

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equivalent of dihydrogen (H2), and the acceptor is a dioxygen. Similarly, a peroxidase (another subclass of oxidoreductases) will use a peroxide (H2O2) as the...

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Respiratory burst

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NADPH oxidase (NOX2 in humans) activity. NADPH is the key substrate of NOX2, and bears reducing power. Glycogen breakdown is vital to produce NADPH....

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Resazurin

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resorufin (used in many assays combining for example horseradish peroxidase (HRP), or NADH, NADPH using enzymes). 7-ethoxyresorufin, a compound used as the substrate...

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Glutathione disulfide

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the coenzyme NADPH. This reaction is catalyzed by the enzyme glutathione reductase. Antioxidant enzymes, such as glutathione peroxidases and peroxiredoxins...

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PRDX5

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yeast peroxisomal antioxidant enzyme PMP20. Biochemically, PRDX5 is a peroxidase that can use cytosolic or mitochondrial thioredoxins to reduce alkyl hydroperoxides...

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Glutathione reductase

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Reduced glutathione reduces the oxidized form of the enzyme glutathione peroxidase, which in turn reduces hydrogen peroxide (H2O2), a dangerously reactive...

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Heinz body

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pathways leading to the hemoglobin damage. NADPH deficiency can cause a dysfunction in glutathione peroxidase which is an enzyme that converts hydrogen...

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Regina Nuzzo

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"Intracellular reduction of selenite into glutathione peroxidase. Evidence for involvement of NADPH and not glutathione as the reductant". Molecular and...

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PRDX6

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(February 1997). "The human homologue of a bovine non-selenium glutathione peroxidase is a novel keratinocyte growth factor-regulated gene". Oncogene. 14 (8):...

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Safrole

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S-transferase activity. PPA also causes a decrease in glutathione and Glutathione peroxidase activity. The epoxide of allylcatechol may also be generated from the...

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Enzyme assay

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released by a reaction will be detected. The detection of horseradish peroxidase by enzymatic chemiluminescence (ECL) is a common method of detecting antibodies...

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