Enzyme family protecting the organism from oxidative damages
Glutathione peroxidase
Crystallographic structure of bovine glutathione peroxidase 1.[1]
Identifiers
EC no.
1.11.1.9
CAS no.
9013-66-5
Databases
IntEnz
IntEnz view
BRENDA
BRENDA entry
ExPASy
NiceZyme view
KEGG
KEGG entry
MetaCyc
metabolic pathway
PRIAM
profile
PDB structures
RCSB PDB PDBe PDBsum
Gene Ontology
AmiGO / QuickGO
Search
PMC
articles
PubMed
articles
NCBI
proteins
Glutathione peroxidase
Identifiers
Symbol
GSHPx
Pfam
PF00255
InterPro
IPR000889
PROSITE
PDOC00396
SCOP2
1gp1 / SCOPe / SUPFAM
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
PDB
2f8aB:14-128 1gp1A:19-133
Glutathione peroxidase (GPx) (EC 1.11.1.9) is the general name of an enzyme family with peroxidase activity whose main biological role is to protect the organism from oxidative damage.[2] The biochemical function of glutathione peroxidase is to reduce lipid hydroperoxides to their corresponding alcohols and to reduce free hydrogen peroxide to water.[3]
^PDB: 1GP1; Epp O, Ladenstein R, Wendel A (June 1983). "The refined structure of the selenoenzyme glutathione peroxidase at 0.2-nm resolution". European Journal of Biochemistry. 133 (1): 51–69. doi:10.1111/j.1432-1033.1983.tb07429.x. PMID 6852035.
^Muthukumar K, Nachiappan V (December 2010). "Cadmium-induced oxidative stress in Saccharomyces cerevisiae". Indian Journal of Biochemistry & Biophysics. 47 (6): 383–7. PMID 21355423.
^Muthukumar K, Rajakumar S, Sarkar MN, Nachiappan V (May 2011). "Glutathione peroxidase3 of Saccharomyces cerevisiae protects phospholipids during cadmium-induced oxidative stress". Antonie van Leeuwenhoek. 99 (4): 761–71. doi:10.1007/s10482-011-9550-9. PMID 21229313. S2CID 21850794.
and 25 Related for: Glutathione peroxidase information
Glutathioneperoxidase (GPx) (EC 1.11.1.9) is the general name of an enzyme family with peroxidase activity whose main biological role is to protect the...
acts on glutathioneperoxidase. Glutathione is used to produce S-sulfanylglutathione, which is part of hydrogen sulfide metabolism. Glutathione facilitates...
Glutathioneperoxidase 1, also known as GPx1, is an enzyme that in humans is encoded by the GPX1 gene on chromosome 3. This gene encodes a member of the...
an electron donor. The glutathione system includes glutathione, glutathione reductase, glutathioneperoxidases, and glutathione S-transferases. This system...
Glutathioneperoxidase 4, also known as GPX4, is an enzyme that in humans is encoded by the GPX4 gene. GPX4 is a phospholipid hydroperoxidase that protects...
oxygen, and various electrophiles. Reduced glutathione reduces the oxidized form of the enzyme glutathioneperoxidase, which in turn reduces hydrogen peroxide...
Twenty-five selenoproteins are encoded in the human genome. The glutathioneperoxidase family of enzymes (abbreviated GSH-Px) catalyze reduction of hydrogen...
glutathione reductase. Antioxidant enzymes, such as glutathioneperoxidases and peroxiredoxins, generate glutathione disulfide during the reduction of peroxides...
(non-catalase) peroxidase but do not have catalase. More specifically, they may use a NADH oxidase/NADH peroxidase (NOX/NPR) system or a glutathioneperoxidase system...
in infant formula, and is a component of the antioxidant enzymes glutathioneperoxidase and thioredoxin reductase (which indirectly reduce certain oxidized...
Glutathioneperoxidase 3 (GPx-3), also known as plasma glutathioneperoxidase (GPx-P) or extracellular glutathioneperoxidase is an enzyme that in humans...
is made, it can be used by glutathioneperoxidase to neutralize reactive oxygen species (ROS) such as H2O2 or Glutathione S-transferases in the detoxification...
activity in the rumen and inactivation of glutathioneperoxidases by the effect of absorbed cyanide on the glutathione moiety. In areas where selenium deficiency...
essential antioxidant enzymes, such as superoxide dismutase, glutathioneperoxidase, glutathione reductase, and catalase. This increase in antioxidant enzyme...
Glutathioneperoxidase 5 (GPx-5), also known as epididymal secretory glutathioneperoxidase is an enzyme that in humans is encoded by the GPX5 gene. GPx-5...
Glutathioneperoxidase 8 (GPx-8) is an enzyme that in humans is encoded by the GPX8 gene. GPx-8 is a member of the glutathioneperoxidase family. GRCh38:...
with rate of DNA repair Female mammals express more Mn−SOD and glutathioneperoxidase antioxidant enzymes than males. This has been hypothesized as the...
oxidative stress. It reduces glutathione via glutathione reductase, which converts reactive H2O2 into H2O by glutathioneperoxidase. If absent, the H2O2 would...
anti-oxidant and cytoprotective activity. It acts as a mimic of glutathioneperoxidase and can also react with peroxynitrite. It is being investigated...
processes. The best known selenoenzyme, glutathioneperoxidase (GPx), catalyzes the reduction of peroxides by glutathione (GSH). The selenenic acid intermediate...
protection against oxytosis/ferroptosis is mediated by glutathioneperoxidase 4 (GPX4), a glutathione-dependent hydroperoxidase that converts lipid peroxides...
plicatilis 'Cayman') enhances the mRNA expression and activity of glutathioneperoxidase in Atlantic cod (Gadus morhua L.) larvae". Aquaculture. 306 (1–4):...
Demonstration of Three Processes Included in the Catalytic Cycle of GlutathionePeroxidase". Organic Letters. 3 (22): 3569–3572. doi:10.1021/ol016682s. PMID 11678710...
Glutathioneperoxidase 7 is an enzyme that in humans is encoded by the GPX7 gene. GRCh38: Ensembl release 89: ENSG00000116157 – Ensembl, May 2017 GRCm38:...
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