oxidoreductase activity, acting on peroxide as acceptor
catalase activity
antioxidant activity
heme binding
NADP binding
enzyme binding
oxidoreductase activity
signaling receptor binding
identical protein binding
Cellular component
cytosol
Golgi apparatus
membrane
intracellular membrane-bounded organelle
focal adhesion
mitochondrial intermembrane space
peroxisomal membrane
peroxisome
plasma membrane
peroxisomal matrix
endoplasmic reticulum
mitochondrion
lysosome
extracellular exosome
extracellular region
extracellular space
secretory granule lumen
ficolin-1-rich granule lumen
Biological process
response to phenylpropanoid
ureteric bud development
response to estradiol
response to hypoxia
response to cadmium ion
response to fatty acid
kidney development
response to inactivity
response to hyperoxia
cellular response to growth factor stimulus
human ageing
cholesterol metabolic process
response to L-ascorbic acid
negative regulation of apoptotic process
response to ozone
response to oxidative stress
response to activity
protein tetramerization
response to vitamin E
response to insulin
response to vitamin A
aerobic respiration
response to lead ion
positive regulation of NF-kappaB transcription factor activity
osteoblast differentiation
hydrogen peroxide catabolic process
UV protection
positive regulation of phosphatidylinositol 3-kinase signaling
response to radiation
response to light intensity
response to ethanol
negative regulation of NF-kappaB transcription factor activity
triglyceride metabolic process
protein homotetramerization
response to UV
response to toxic substance
response to hydrogen peroxide
hemoglobin metabolic process
positive regulation of cell division
cellular oxidant detoxification
neutrophil degranulation
response to reactive oxygen species
cellular response to oxidative stress
protein targeting to peroxisome
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
847
12359
Ensembl
ENSG00000121691
ENSMUSG00000027187
UniProt
P04040
P24270
RefSeq (mRNA)
NM_001752
NM_009804
RefSeq (protein)
NP_001743
NP_033934
Location (UCSC)
Chr 11: 34.44 – 34.47 Mb
Chr 2: 103.28 – 103.32 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Catalase is a common enzyme found in nearly all living organisms exposed to oxygen (such as bacteria, plants, and animals) which catalyzes the decomposition of hydrogen peroxide to water and oxygen.[5] It is a very important enzyme in protecting the cell from oxidative damage by reactive oxygen species (ROS). Catalase has one of the highest turnover numbers of all enzymes; one catalase molecule can convert millions of hydrogen peroxide molecules to water and oxygen each second.[6]
Catalase is a tetramer of four polypeptide chains, each over 500 amino acids long.[7] It contains four iron-containing heme groups that allow the enzyme to react with hydrogen peroxide. The optimum pH for human catalase is approximately 7,[8] and has a fairly broad maximum: the rate of reaction does not change appreciably between pH 6.8 and 7.5.[9] The pH optimum for other catalases varies between 4 and 11 depending on the species.[10] The optimum temperature also varies by species.[11]
^ abcGRCh38: Ensembl release 89: ENSG00000121691 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000027187 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Chelikani P, Fita I, Loewen PC (January 2004). "Diversity of structures and properties among catalases". Cellular and Molecular Life Sciences. 61 (2): 192–208. doi:10.1007/s00018-003-3206-5. hdl:10261/111097. PMID 14745498. S2CID 4411482.
^Goodsell DS (2004-09-01). "Catalase". Molecule of the Month. RCSB Protein Data Bank. Retrieved 2016-08-23.
^Boon EM, Downs A, Marcey D. "Catalase: H2O2: H2O2 Oxidoreductase". Catalase Structural Tutorial Text. Retrieved 2007-02-11.
^Maehly AC, Chance B (1954). "The assay of catalases and peroxidases". Methods of Biochemical Analysis. Vol. 1. pp. 357–424. doi:10.1002/9780470110171.ch14. ISBN 978-0-470-11017-1. PMID 13193536.
^Aebi H (1984). "Catalase in vitro". Oxygen Radicals in Biological Systems. Methods in Enzymology. Vol. 105. pp. 121–6. doi:10.1016/S0076-6879(84)05016-3. ISBN 978-0-12-182005-3. PMID 6727660.
^"EC 1.11.1.6 - catalase". BRENDA: The Comprehensive Enzyme Information System. Department of Bioinformatics and Biochemistry, Technische Universität Braunschweig. Retrieved 2009-05-26.
^Toner K, Sojka G, Ellis R. "A Quantitative Enzyme Study; CATALASE". bucknell.edu. Archived from the original on 2000-06-12. Retrieved 2007-02-11.
Catalase is a common enzyme found in nearly all living organisms exposed to oxygen (such as bacteria, plants, and animals) which catalyzes the decomposition...
aerotolerant anaerobes have superoxide dismutase and (non-catalase) peroxidase but do not have catalase. More specifically, they may use a NADH oxidase/NADH...
saprotrophic coccus bacterium in the family Micrococcaceae. It is urease and catalase positive. An obligate aerobe, M. luteus is found in soil, dust, water and...
removal, humans with genetic deficiency of catalase — "acatalasemia" — or mice genetically engineered to lack catalase completely, experience few ill effects...
colonize H. pylori uses many different virulence factors including oxidase, catalase, and urease. Urease is the most abundant protein, its expression representing...
known also as the hay bacillus or grass bacillus, is a gram-positive, catalase-positive bacterium, found in soil and the gastrointestinal tract of ruminants...
KatG is an enzyme that functions as both catalase and peroxidase. Its mutation is the cause for Mycobacterium (specifically M. tuberculosis) resistance...
Acid from sucrose + Nitrate reduction + (to nitrite) Deoxyribonuclease, 25 °C + Lipase + Pigment some biovars produce red Catalase production (24h) +...
inhabits the oral cavity. It is coccus (spherical shaped), gram-positive, catalase negative, and facultative anaerobe. It was previously classified as Streptococcus...
Bilophila wadsworthia is a Gram-negative, obligately anaerobic, catalase-positive, bile-resistant, and asaccharolytic bacillus. Approximately 75% of B...
reaction is catalyzed by enzymes (proteins that serve as catalysts) such as catalase. The SI derived unit for measuring the catalytic activity of a catalyst...
spp. and Streptococcus spp. is the catalase test. Staphylococci are catalase positive whereas streptococci are catalase-negative. S. pyogenes can be cultured...
accumulation of hydrogen peroxide and abnormally low levels of the enzyme catalase, which breaks down hydrogen peroxide and relieves oxidative stress in patients...
they do not produce coagulase. S. aureus is catalase-positive (meaning that it can produce the enzyme catalase) and able to convert hydrogen peroxide (H2O2)...
the upper respiratory tract and on the skin. It is often positive for catalase and nitrate reduction and is a facultative anaerobe that can grow without...
can usually resist infections of catalase-negative bacteria but are susceptible to catalase-positive bacteria. Catalase is an enzyme that catalyzes the...
Hydrogen peroxide is also damaging and is degraded by other enzymes such as catalase. Thus, SOD is an important antioxidant defense in nearly all living cells...
hydroquinones and hydrogen peroxide, the other holding hydrogen peroxide and catalase enzymes. These chemicals mix and result in an explosive ejection, reaching...
increases serum levels of creatinine, uric acid or hemoglobin. Inhibited by catalase. Kodak Ektachem A dry chemistry method. Uses spectrophotometry to measure...
known as Enterobacter aerogenes, is a Gram-negative, oxidase-negative, catalase-positive, citrate-positive, indole-negative, rod-shaped bacterium. Capable...
Enterobacteriaceae generally lack cytochrome c oxidase, there are exceptions. Catalase reactions vary among Enterobacteriaceae. Many members of this family are...
low levels of the enzyme catalase. Catalase breaks down hydrogen peroxide in cells into water and oxygen. Low levels of catalase can cause hydrogen peroxide...
(H2O2), the byproduct of oxalate oxidase reaction, can be neutralized by catalase. Alarm photosynthesis represents a photosynthetic variant to be added to...
grape-like clusters of cells. Most streptococci are oxidase-negative and catalase-negative, and many are facultative anaerobes (capable of growth both aerobically...
of this metabolism is either water or hydrogen peroxide (broken down by catalase). Wet each disk with about four inoculating loops of deionized water. Use...
Global Information
