Monastrol
Names
IUPAC name
ethyl 4-(3-hydroxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate
Other names
Monastrol
Identifiers
CAS Number
329689-23-8 N
3D model (JSmol)
ChEBI
CHEBI:75382 Y
ChEMBL
ChEMBL236789 Y
ChemSpider
2259791 Y
DTXSID501317756 DTXSID10388124, DTXSID501317756
InChI=1S/C14H16N2O3S/c1-3-19-13(18)11-8(2)15-14(20)16-12(11)9-5-4-6-10(17)7-9/h4-7,12,17H,3H2,1-2H3,(H2,15,16,20)
N Key: LOBCDGHHHHGHFA-UHFFFAOYSA-N
Y InChI=1/C14H16N2O3S/c1-3-19-13(18)11-8(2)15-14(20)16-12(11)9-5-4-6-10(17)7-9/h4-7,12,17H,3H2,1-2H3,(H2,15,16,20)
Key: LOBCDGHHHHGHFA-UHFFFAOYAO
CCOC(=O)C1=C(NC(=S)NC1C2=CC(=CC=C2)O)C
Properties
Chemical formula
C14 H16 N2 O3 S
Molar mass
292.35344
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Chemical compound
Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin-5 (also known as KIF11, Kinesin Eg5), a motor protein important for spindle bipolarity.[1]
^ Thomas U. Mayer; Tarun M. Kapoor; Stephen J. Haggarty; Randall W. King; Stuart L. Schreiber; Timothy J. Mitchison (1999). "Small Molecule Inhibitor of Mitotic Spindle Bipolarity Identified in a Phenotype-Based Screen". Science . 286 (5441): 971–974. doi:10.1126/science.286.5441.971. PMID 10542155. S2CID 15348455.
Last Update: 2023-10-31T11:32:08Z
Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin-5...
Word Count : 156
Last Update: 2023-12-01T02:59:12Z
discovering the small molecule monastrol – the first small-molecule inhibitor of mitosis that does not target tubulin. Monastrol was shown to inhibit kinesin-5...
Word Count : 1278
Last Update: 2024-04-11T04:52:38Z
honokiol, magnolol, obovatol) Loreclezole Menthyl isovalerate (validolum) Monastrol Niacin Niacinamide Org 25,435 Phenytoin Propanidid Retigabine (ezogabine)...
Word Count : 10073
Last Update: 2024-05-19T18:14:47Z
honokiol, magnolol, obovatol) Loreclezole Menthyl isovalerate (validolum) Monastrol Niacin Niacinamide Org 25,435 Phenytoin Propanidid Retigabine (ezogabine)...
Word Count : 2425
Last Update: 2024-05-13T23:06:16Z
honokiol, magnolol, obovatol) Loreclezole Menthyl isovalerate (validolum) Monastrol Niacin Niacinamide Org 25,435 Phenytoin Propanidid Retigabine (ezogabine)...
Word Count : 3083
Last Update: 2024-05-29T04:59:57Z
honokiol, magnolol, obovatol) Loreclezole Menthyl isovalerate (validolum) Monastrol Niacin Niacinamide Org 25,435 Phenytoin Propanidid Retigabine (ezogabine)...
Word Count : 2516
Last Update: 2024-06-02T19:44:20Z
honokiol, magnolol, obovatol) Loreclezole Menthyl isovalerate (validolum) Monastrol Niacin Niacinamide Org 25,435 Phenytoin Propanidid Retigabine (ezogabine)...
Word Count : 8229
Last Update: 2024-05-12T19:07:45Z
Isonipecotic acid Kojic amine L-838,417 Lignans (e.g., honokiol) Methylglyoxal Monastrol Muscimol Nefiracetam Neuroactive steroids (e.g., allopregnanolone) Org...
Word Count : 10497
Last Update: 2024-05-18T13:15:50Z
Isonipecotic acid Kojic amine L-838,417 Lignans (e.g., honokiol) Methylglyoxal Monastrol Muscimol Nefiracetam Neuroactive steroids (e.g., allopregnanolone) Org...
Word Count : 6690
Last Update: 2023-12-20T19:27:11Z
honokiol, magnolol, obovatol) Loreclezole Menthyl isovalerate (validolum) Monastrol Niacin Niacinamide Org 25,435 Phenytoin Propanidid Retigabine (ezogabine)...
Word Count : 838
Last Update: 2024-05-26T21:23:11Z
honokiol, magnolol, obovatol) Loreclezole Menthyl isovalerate (validolum) Monastrol Niacin Niacinamide Org 25,435 Phenytoin Propanidid Retigabine (ezogabine)...
Word Count : 5291
Last Update: 2024-05-25T10:58:02Z
honokiol, magnolol, obovatol) Loreclezole Menthyl isovalerate (validolum) Monastrol Niacin Niacinamide Org 25,435 Phenytoin Propanidid Retigabine (ezogabine)...
Word Count : 16667
Last Update: 2024-06-02T17:29:00Z
honokiol, magnolol, obovatol) Loreclezole Menthyl isovalerate (validolum) Monastrol Niacin Niacinamide Org 25,435 Phenytoin Propanidid Retigabine (ezogabine)...
Word Count : 7917
Last Update: 2024-04-21T01:47:04Z
Isonipecotic acid Kojic amine L-838,417 Lignans (e.g., honokiol) Methylglyoxal Monastrol Muscimol Nefiracetam Neuroactive steroids (e.g., allopregnanolone) Org...
Word Count : 5404
Last Update: 2024-05-25T01:56:24Z
honokiol, magnolol, obovatol) Loreclezole Menthyl isovalerate (validolum) Monastrol Niacin Niacinamide Org 25,435 Phenytoin Propanidid Retigabine (ezogabine)...
Word Count : 4938
Last Update: 2024-05-30T11:59:23Z
honokiol, magnolol, obovatol) Loreclezole Menthyl isovalerate (validolum) Monastrol Niacin Niacinamide Org 25,435 Phenytoin Propanidid Retigabine (ezogabine)...
Word Count : 5623
Last Update: 2024-05-19T05:25:24Z
Isonipecotic acid Kojic amine L-838,417 Lignans (e.g., honokiol) Methylglyoxal Monastrol Muscimol Nefiracetam Neuroactive steroids (e.g., allopregnanolone) Org...
Word Count : 2651
Last Update: 2024-06-01T10:13:34Z
Isonipecotic acid Kojic amine L-838,417 Lignans (e.g., honokiol) Methylglyoxal Monastrol Muscimol Nefiracetam Neuroactive steroids (e.g., allopregnanolone) Org...
Word Count : 3210
Last Update: 2024-05-13T04:35:47Z
honokiol, magnolol, obovatol) Loreclezole Menthyl isovalerate (validolum) Monastrol Niacin Niacinamide Org 25,435 Phenytoin Propanidid Retigabine (ezogabine)...
Word Count : 1575
Last Update: 2024-05-26T23:34:08Z
honokiol, magnolol, obovatol) Loreclezole Menthyl isovalerate (validolum) Monastrol Niacin Niacinamide Org 25,435 Phenytoin Propanidid Retigabine (ezogabine)...
Word Count : 5515
Last Update: 2024-05-24T16:49:45Z
honokiol, magnolol, obovatol) Loreclezole Menthyl isovalerate (validolum) Monastrol Niacin Niacinamide Org 25,435 Phenytoin Propanidid Retigabine (ezogabine)...
Word Count : 4697
Last Update: 2024-05-26T06:54:59Z
honokiol, magnolol, obovatol) Loreclezole Menthyl isovalerate (validolum) Monastrol Niacin Niacinamide Org 25,435 Phenytoin Propanidid Retigabine (ezogabine)...
Word Count : 8518
Last Update: 2024-06-03T19:34:26Z
honokiol, magnolol, obovatol) Loreclezole Menthyl isovalerate (validolum) Monastrol Niacin Niacinamide Org 25,435 Phenytoin Propanidid Retigabine (ezogabine)...
Word Count : 7419
Last Update: 2024-05-25T10:45:05Z
honokiol, magnolol, obovatol) Loreclezole Menthyl isovalerate (validolum) Monastrol Niacin Niacinamide Org 25,435 Phenytoin Propanidid Retigabine (ezogabine)...
Word Count : 1924
Last Update: 2024-05-07T14:42:43Z
honokiol, magnolol, obovatol) Loreclezole Menthyl isovalerate (validolum) Monastrol Niacin Niacinamide Org 25,435 Phenytoin Propanidid Retigabine (ezogabine)...
Word Count : 2533