OMA1 information

OMA1
Identifiers
Aliases	OMA1, 2010001O09Rik, DAB1, MPRP-1, YKR087C, ZMPpeptidase, OMA1 zinc metallopeptidase, MPRP1
External IDs	OMIM: 617081 MGI: 1914263 HomoloGene: 12070 GeneCards: OMA1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	58,546,802 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	103,229,065 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; Achilles tendon; ; bone marrow cells; ; right uterine tube; ; corpus callosum; ; caput epididymis; ; renal medulla; ; right adrenal gland; ; superior surface of tongue; ; rectum;
	Top expressed in
	interventricular septum; ; right ventricle; ; myocardium of ventricle; ; sternocleidomastoid muscle; ; digastric muscle; ; temporal muscle; ; epithelium of stomach; ; vastus lateralis muscle; ; tibialis anterior muscle; ; extraocular muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase activity; hydrolase activity; metallopeptidase activity; metal ion binding; metalloendopeptidase activity;
Cellular component	membrane; integral component of membrane; mitochondrial membranes; mitochondrion; mitochondrial inner membrane;
Biological process	mitochondrial protein processing; energy homeostasis; response to stress; mitochondrion organization; cristae formation; protein quality control for misfolded or incompletely synthesized proteins; negative regulation of mitochondrial fusion; proteolysis; lipid metabolism; glucose metabolic process; diet induced thermogenesis; regulation of apoptotic process; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	115209
	67013
	ENSG00000162600
	ENSMUSG00000035069
	Q96E52
	Q9D8H7
	NM_145243
	NM_025909
	NP_660286
	NP_080185
	Wikidata
View/Edit Human	View/Edit Mouse

Metalloendopeptidase OMA1, mitochondrial is an enzyme that in humans is encoded by the OMA1 gene.^[5]^[6] OMA1 is a Zn²⁺-dependent metalloendopeptidase in the inner membrane of mitochondria. The OMA1 acronym was derived from overlapping proteolytic activity with m-AAA protease 1.^[6]

The OMA1 protease acts at the intersection of a mitochondrial quality control system and energy metabolism, whereby its activation correlates with outer membrane permeabilization and cytochrome c release in the context of apoptosis.

Mammalian OMA1 can cleave the inner-membrane shaping protein OPA1 and the signaling peptide DELE1 in a context-dependent manner.^[7]^[8]^[9]^[10]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000162600 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035069 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: OMA1 zinc metallopeptidase".
^ ^a ^b Kaser M, Kambacheld M, Kisters-Woike B, Langer T (November 2003). "Oma1, a novel membrane-bound metallopeptidase in mitochondria with activities overlapping with the m-AAA protease". The Journal of Biological Chemistry. 278 (47): 46414–23. doi:10.1074/jbc.m305584200. PMID 12963738.
^ Ehses S, Raschke I, Mancuso G, Bernacchia A, Geimer S, Tondera D, et al. (December 2009). "Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1". The Journal of Cell Biology. 187 (7): 1023–36. doi:10.1083/jcb.200906084. PMC 2806285. PMID 20038678.
^ Head B, Griparic L, Amiri M, Gandre-Babbe S, van der Bliek AM (December 2009). "Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cells". The Journal of Cell Biology. 187 (7): 959–66. doi:10.1083/jcb.200906083. PMC 2806274. PMID 20038677.
^ Guo X, Aviles G, Liu Y, Tian R, Unger BA, Lin YT, et al. (March 2020). "Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway". Nature. 579 (7799): 427–432. Bibcode:2020Natur.579..427G. doi:10.1038/s41586-020-2078-2. PMC 7147832. PMID 32132707.
^ Fessler E, Eckl EM, Schmitt S, Mancilla IA, Meyer-Bender MF, Hanf M, et al. (March 2020). "A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol". Nature. 579 (7799): 433–437. Bibcode:2020Natur.579..433F. doi:10.1038/s41586-020-2076-4. PMC 7116715. PMID 32132706.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162600 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035069 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: OMA1 zinc metallopeptidase".

[ReferenceA-6] Kaser M, Kambacheld M, Kisters-Woike B, Langer T (November 2003). "Oma1, a novel membrane-bound metallopeptidase in mitochondria with activities overlapping with the m-AAA protease". The Journal of Biological Chemistry. 278 (47): 46414–23. doi:10.1074/jbc.m305584200. PMID 12963738.

[:0-7] Ehses S, Raschke I, Mancuso G, Bernacchia A, Geimer S, Tondera D, et al. (December 2009). "Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1". The Journal of Cell Biology. 187 (7): 1023–36. doi:10.1083/jcb.200906084. PMC 2806285. PMID 20038678.

[:1-8] Head B, Griparic L, Amiri M, Gandre-Babbe S, van der Bliek AM (December 2009). "Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cells". The Journal of Cell Biology. 187 (7): 959–66. doi:10.1083/jcb.200906083. PMC 2806274. PMID 20038677.

[:2-9] Guo X, Aviles G, Liu Y, Tian R, Unger BA, Lin YT, et al. (March 2020). "Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway". Nature. 579 (7799): 427–432. Bibcode:2020Natur.579..427G. doi:10.1038/s41586-020-2078-2. PMC 7147832. PMID 32132707.

[:3-10] Fessler E, Eckl EM, Schmitt S, Mancilla IA, Meyer-Bender MF, Hanf M, et al. (March 2020). "A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol". Nature. 579 (7799): 433–437. Bibcode:2020Natur.579..433F. doi:10.1038/s41586-020-2076-4. PMC 7116715. PMID 32132706.

OMA1 information

and 4 Related for: OMA1 information

OMA1

Chromosome 1

YME1L1

UQCC3