TFAM information

TFAM
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3FGH, 3TMM, 3TQ6, 4NNU, 4NOD
Identifiers
Aliases	TFAM, MTTF1, MTTFA, TCF6, TCF6L1, TCF6L2, TCF6L3, transcription factor A, mitochondrial, MTDPS15
External IDs	OMIM: 600438; MGI: 107810; HomoloGene: 31139; GeneCards: TFAM; OMA:TFAM - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	58,399,220 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	71,074,110 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; secondary oocyte; ; Achilles tendon; ; ventricular zone; ; monocyte; ; germinal epithelium; ; ganglionic eminence; ; mucosa of sigmoid colon; ; gonad;
	Top expressed in
	ventricular zone; ; endocardial cushion; ; atrioventricular valve; ; abdominal wall; ; embryo; ; somite; ; migratory enteric neural crest cell; ; epiblast; ; muscle of thigh; ; triceps brachii muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; mitochondrial promoter sequence-specific DNA binding; heat shock protein binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; chromatin binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein binding; transcription coactivator binding; DNA binding, bending; RNA binding; sequence-specific DNA binding;
Cellular component	cytosol; mitochondrial matrix; mitochondrion; mitochondrial nucleoid; nucleus; protein-containing complex;
Biological process	DNA-dependent DNA replication; regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase I; transcription initiation from mitochondrial promoter; mitochondrion organization; transcription, DNA-templated; positive regulation of transcription, DNA-templated; mitochondrial respiratory chain complex assembly; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; mitochondrial transcription;
	Sources:Amigo / QuickGO
Orthologs
	7019
	21780
	ENSG00000108064
	ENSMUSG00000003923
	Q00059
	P40630
	NM_001270782; NM_003201; NM_012251
	NM_009360
	NP_001257711; NP_003192
	NP_033386
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial transcription factor A, abbreviated as TFAM or mtTFA, is a protein that in humans is encoded by the TFAM gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000108064 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003923 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tiranti V, Rossi E, Ruiz-Carrillo A, Rossi G, Rocchi M, DiDonato S, Zuffardi O, Zeviani M (Jul 1995). "Chromosomal localization of mitochondrial transcription factor A (TCF6), single-stranded DNA-binding protein (SSBP), and endonuclease G (ENDOG), three human housekeeping genes involved in mitochondrial biogenesis". Genomics. 25 (2): 559–64. doi:10.1016/0888-7543(95)80058-T. PMID 7789991.
^ "Entrez Gene: TFAM transcription factor A, mitochondrial".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000108064 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000003923 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7789991-5] Tiranti V, Rossi E, Ruiz-Carrillo A, Rossi G, Rocchi M, DiDonato S, Zuffardi O, Zeviani M (Jul 1995). "Chromosomal localization of mitochondrial transcription factor A (TCF6), single-stranded DNA-binding protein (SSBP), and endonuclease G (ENDOG), three human housekeeping genes involved in mitochondrial biogenesis". Genomics. 25 (2): 559–64. doi:10.1016/0888-7543(95)80058-T. PMID 7789991.

[entrez-6] "Entrez Gene: TFAM transcription factor A, mitochondrial".

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