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Medical condition
Insulin resistance
Specialty
Endocrinology
Insulin resistance (IR) is a pathological condition in which cells either fail to respond normally to the hormone insulin or downregulate insulin receptors in response to hyperinsulinemia.
Insulin is a hormone that facilitates the transport of glucose from blood into cells, thereby reducing blood glucose (blood sugar). Insulin is released by the pancreas in response to carbohydrates consumed in the diet. In states of insulin resistance, the same amount of insulin does not have the same effect on glucose transport and blood sugar levels. There are many causes of insulin resistance and the underlying process is still not completely understood. Risk factors for insulin resistance include obesity, sedentary lifestyle, family history of diabetes, various health conditions, and certain medications. Insulin resistance is considered a component of the metabolic syndrome. There are multiple ways to measure insulin resistance such as fasting insulin levels or glucose tolerance tests, but these are not often used in clinical practice. Insulin resistance can be improved or reversed with lifestyle approaches, such as weight reduction, exercise, and dietary changes.
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Insulinresistance (IR) is a pathological condition in which cells either fail to respond normally to the hormone insulin or downregulate insulin receptors...
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Insulin (/ˈɪn.sjʊ.lɪn/, from Latin insula, 'island') is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the insulin...
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insulinresistance in the global population. Insulinresistance increases hyperglycemia because the body becomes over saturated by glucose. Insulin resistance...
endocrine dysfunction, especially insulinresistance and hyperinsulinaemia, as seen in diabetes mellitus. This activates the insulin-like growth factor receptors...
characteristics of this syndrome include: hyperandrogenism, anovulation, insulinresistance, and neuroendocrine disruption. A review of international evidence...
increasing with age, particularly among racial and ethnic minorities. Insulinresistance, metabolic syndrome, and prediabetes are closely related to one another...
gluconeogenesis in the fasted state, but insulin blocks FOXO6 upon feeding. In a condition of insulinresistance, insulin fails to block FOXO6 resulting in continued...
subcutaneous injection. Diabetes mellitus type 2 is a disease of insulinresistance by cells. Type 2 diabetes mellitus is the most common type of diabetes...
School of Medicine. It was called "resistin" because of the observed insulinresistance in mice injected with resistin. Resistin was found to be produced...
syndrome. The beta cells can still secrete insulin but the body has developed a resistance and its response to insulin has declined. It is believed to be due...
the insulin signaling cascade. Increased plasma free-fatty acid levels and increased accumulation of IMTG correlate well with insulinresistance in muscles...
branched-chain amino acids, are associated with weight loss and decreased insulinresistance: higher levels of valine are observed in the blood of diabetic mice...
development of Alzheimer's disease in people with diabetes. But while insulinresistance is a risk factor for the development of Alzheimer's disease and some...
of 35), had a higher likelihood of metabolic syndrome (MetS) and insulinresistance. With younger males, studies found metabolic syndrome to be at approximately...
with insulinresistance: higher levels of isoleucine are observed in the blood of diabetic mice, rats, and humans. In diet-induced obese and insulin resistant...
prediabetes occurs when control of insulin and blood glucose in the body becomes abnormal, also known as insulinresistance. Risk factors for developing prediabetes...
hyperandrogenism cases. Other causes include Congenital adrenal hyperplasia, insulinresistance, hyperprolactinemia, Cushing's disease, certain types of cancers,...
relationship between dietary fats and insulinresistance is presumed secondary to the relationship between insulinresistance and inflammation, which is partially...
addition, it demonstrates favourable effects on parameters of the insulinresistance syndrome, apparently independent of blood pressure reduction. It is...
manner to insulin. If the amount of insulin available is insufficient, or if cells respond poorly to the effects of insulin (insulinresistance), or if...
Delta waves are high amplitude neural oscillations with a frequency between 0.5 and 4 hertz. Delta waves, like other brain waves, can be recorded with...
form of diabetes, similar to T1D, but patients with LADA often show insulinresistance, similar to T2D, and share some risk factors for the disease with...
Gestational diabetes can occur during pregnancy because of insulinresistance or reduced production of insulin. Risk factors include being overweight, previously...
mellitus (T2DM). Insulinresistance is a major feature of diabetes mellitus type 2, and central obesity is correlated with both insulinresistance and T2DM itself...
Hyperinsulinemia is associated with hypertension, obesity, dyslipidemia, insulinresistance, and glucose intolerance. These conditions are collectively known...
cleared from the blood. The test is usually used to test for diabetes, insulinresistance, impaired beta cell function, and sometimes reactive hypoglycemia...
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