Mast cell leukemia is an extremely aggressive subtype of acute myeloid leukemia that usually occurs de novo but can, rarely, evolve from transformation of chronic myeloid leukemia into the more aggressive acute myeloid leukemia. In a small proportion of cases, acute mast cell leukemia may evolve from a more progressive form of systemic mastocytosis. The diagnosis of acute mast cell leukemia by the WHO criteria includes the requirement for a prevalence of 20% neoplastic mast cells in marrow and 10% in blood.[1] If the mast cells represent less than 10% of blood cells, the tumor is called "aleukemic" mast cell leukemia.
Mastcellleukemia is an extremely aggressive subtype of acute myeloid leukemia that usually occurs de novo but can, rarely, evolve from transformation...
A mastcell (also known as a mastocyte or a labrocyte) is a resident cell of connective tissue that contains many granules rich in histamine and heparin...
Chronic myelogenous leukemia (CML), also known as chronic myeloid leukemia, is a cancer of the white blood cells. It is a form of leukemia characterized by...
without destructive growth. In the cases observed, mastcell sarcoma terminated quickly as mastcellleukemia; one of the most aggressive human cancers. Mastocytosis...
Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone...
A mastocytoma in dogs (or mastcell tumor in dogs) is a neoplasm (neoplasia) originating from mastcells in the domestic dog, which occurs mainly in the...
on the manual differential in some cases of lymphoma, and in mastcellleukemia, mastcells, which are normally confined to tissue, circulate in the blood...
type of mastcell disease, is a rare disorder affecting both children and adults caused by the accumulation of functionally defective mastcells (also called...
Kröger N, Mesa RA (March 2008). "Choosing between stem cell therapy and drugs in myelofibrosis". Leukemia. 22 (3): 474–486. doi:10.1038/sj.leu.2405080. PMID 18185525...
thrombocytes, macrophages and mastcells; the lymphoid cell line produces B, T, NK and plasma cells. Lymphomas, lymphocytic leukemias, and myeloma are from the...
granule-derived serine proteinase contained in mastcells and has been used as a marker for mastcell activation. Club cells contain tryptase, which is believed...
These cancers include leukemias, lymphomas, and myelomas. These particular types of cancers can arise as defected mature cell types that have differentiated...
Wiktionary, the free dictionary. MCL may refer to: Mantle cell lymphoma Mastcellleukemia Medial collateral ligament Medical Center Leeuwarden Microlitre...
(monocytes, and lymphocytes (T cells and B cells)). Myeloid cells (myelocytes) include neutrophils, eosinophils, mastcells, basophils, and monocytes. Monocytes...
advanced systemic mastocytosis, including the highly fatal variant mastcellleukemia. Common side effects include immune system related problems (fever...
of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mastcellleukemiacell line expressing substantial amounts of abnormal...
Granulopoiesis (or granulocytopoiesis) is haematopoiesis of granulocytes, except mastcells which are granulocytes but with an extramedullar maturation. Thrombopoiesis...
certain forms of cancer such as leukemia. Several types of stem cells are related to bone marrow. Hematopoietic stem cells in the bone marrow can give rise...
on human mastcells, including primary CD34+ progenitor cell-derived mastcells and the LAD2 cell line. Examining the proteome of mastcells from several...
initiated by cells already present in all tissues, mainly resident macrophages, dendritic cells, histiocytes, Kupffer cells, and mastcells. These cells present...
blood clotting, although there are less than that found in mastcell granules. Mastcells were once thought to be basophils that migrated from the blood...
systemic mastocytosis with an associated hematological neoplasm, and mastcellleukemia (MCL). The U.S. Food and Drug Administration (FDA) approved avapritinib...
caused by mutations in the eosinophil cell line of one of these three genes), 'b) Chronic eosinophilic leukemia, and c) the Idiopathic hypereosinophiic...
PDGFR-β. Specifically, it is used for chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL) that are Philadelphia chromosome–positive (Ph+)...
differentiated cases made by electron microscopy. May manifest basophil and mastcell granules by EM. Cytogenetically heterogeneous but frequently associated...
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